Results 81 to 90 of about 68,768 (336)

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]

, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bain, MD, Bax, BE, Filosto, M, Moran, N, Scarpelli, M, Tonin, P   +5 more
core   +1 more source

Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects

Allergo Journal International, 2014
SummaryRupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of
Soja Shamizadeh, K. Brockow, J. Ring
semanticscholar   +1 more source

Unveiling CLC as a Central Regulator of Allergic Rhinitis via the CLC‐CCL26/POSTN Axis: An Integrated Bioinformatics and Experimental Study

Flavour and Fragrance Journal, EarlyView.
We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan, Yuhan Dong, Zishuo Guo, Xiaodong Zhao, Jian Liu, Fangyuan Zhu, Shengjie Ge, Chengcheng Liu, Shuai Xu, Ming Xia   +9 more
wiley   +1 more source

How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review

Drugs in Context
The off-label use of second-generation antihistamines, used outside of the formal indications authorized by regulatory authorities, in different age groups, doses or in special populations, is very common for many allergic, autoimmune and dermatological ...
Iñaki Izquierdo, Laia Casas, Susana Cabrera, Alberto Fernandez   +3 more
doaj   +1 more source

An Exploratory Analysis of Pharmaceutical Price Disparities and Their Implications Among Six Developed Nations [PDF]

, 2006
In our study of 43 drugs, prescription drug prices in several wealthy nations (Australia, Canada, France, Germany, and the U.K.) were much lower than in the U.S. on average, well below relative per capita GDP. There was relatively little difference among
Elizabeth DuPre, John E. Calfee, Mario Villarreal   +2 more
core  

Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus

Journal of Medicinal Chemistry, 2014
Staphylococcus aureus is a rapidly growing health threat in the U.S., with resistance to several commonly prescribed treatments. A high-throughput screen identified the antihistamine terfenadine to possess, previously unreported, antimicrobial activity ...
Jessamyn I. Perlmutter, Lauren T. Forbes, D. Krysan, Katherine Ebsworth-Mojica, J. Colquhoun, Jenna L. Wang, P. Dunman, D. Flaherty   +7 more
semanticscholar   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Eradication Therapy for Urticaria with High Titers of Anti H. pylori IgG Antibody

Allergology International, 2014
Background: It is known that idiopathic chronic urticaria occasionally develops with Helicobacter pylori (H. pylori) infection, but the association between urticaria and H. pylori remains unknown. Methods: We focused on the relationship between the titer
Takashi Yoshimasu, Fukumi Furukawa
doaj   +1 more source

Night-time sedating H1-antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial

British Journal of Dermatology, 2014
Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second‐generation H1‐antihistamine in the morning and a sedating first‐generation H1‐antihistamine, usually hydroxyzine, at night to enhance sleep ...
M. Staevska, M. Gugutkova, C. Lazarova, T. Kralimarkova, V. Dimitrov, T. Zuberbier, M. K. Church, Todor A Popov   +7 more
semanticscholar   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source