Results 281 to 290 of about 107,975 (358)

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, EarlyView.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Cocoa shell extract supplementation in hypertensive rats induces outward hypertrophic remodelling in mesenteric resistance arteries, reducing fibrosis

Experimental Physiology, EarlyView.
Abstract Hypertension is the leading risk factor for cardiovascular diseases and is difficult to control, putting the focus on foods and nutraceuticals. Cocoa has beneficial cardiovascular effects but generates large amounts of residues, such as cocoa shells, which contain bioactive molecules.
Pilar Rodríguez‐Rodríguez, Santiago Ruvira, Fatima Abderrahim, Dolores Morales, Metee Iampanichakul, Lucía Juárez, David Ramiro‐Cortijo, Silvia M. Arribas   +7 more
wiley   +1 more source

Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS‐CoV‐2 infection

Experimental Physiology, EarlyView.
Abstract Following an acute infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a substantial percentage of patients report the persistence of debilitating symptoms, often grouped in a syndrome termed ‘long COVID’. We sought to identify potential pathophysiological mechanisms responsible for the persistence, in some long COVID ...
Giovanni Baldassarre, Lucrezia Zuccarelli, Thomas Favaretto, Caterina Ursella, Andrea Palomba, Paulo Cesar do Nascimento Salvador, Emanuela Sozio, Ernesto Crisafulli, Massimo Imazio, Carlo Tascini, Bruno Grassi   +10 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Olmesartan‐induced gastritis with no lower gastrointestinal symptoms: A case report

DEN Open, Volume 6, Issue 1, April 2026.
Abstract A 74‐year‐old man with decreased appetite, weight, and heartburn was referred to our hospital. His medications included olmesartan. Esophagogastroduodenoscopy (EGD) revealed antral‐dominant erosive gastritis and nodular mucosa. A gastric biopsy revealed inflammatory cell infiltration.
Satoshi Kosaka, Miki Kamiyama, Masahiro Ochi   +2 more
wiley   +1 more source

Aripiprazole overdose in Hong Kong: A 10‐year retrospective cohort

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 5, October 2025.
Abstract Introduction Aripiprazole is considered to have a favourable safety profile in overdose, with low risks of cardiovascular and neurological toxicity. However, local data are limited, and the impact of co‐ingestants remains insufficiently studied.
Tun Kin Lam, Shan Liu, Chun Fai Hui
wiley   +1 more source

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, Volume 45, Issue 10, Page 2055-2067, October 2025.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som)

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Pediococcus pentosaceus BBS1 was analyzed by whole genome sequencing for its classification, annotated its main features for significant genes, and safety characteristics. The strain has the potential to be used as a beneficial probiotic starter culture, improving the quality of the fermented bamboo and related products. ABSTRACT Currently, there is an
Viengvilaiphone Botthoulath, Ida F. Dalmacio, Francisco B. Elegado, Lawrence Yves Uy, Hsiang‐Chun Lin   +4 more
wiley   +1 more source

The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti‐inflammatory ...
Xiaoqin Shan, Siyi Li, Jiayi Liu, Can Wang, Yao Wei, Jiayi Shi, Xinyue Zhang, Lili Gu   +7 more
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source