Results 301 to 310 of about 107,975 (358)
Dihydropyridines As Antihypertensive Agents [PDF]
, 1986 Vascular smooth muscle tone is increased by inward transmembrane flux of Ca2+ through voltage-dependent and receptor-operated channels, as well as from intracellular stores. Calcium entry blockers selectively and reversibly reduce the influx of Ca2+ into the cell through the cell membrane and from bound sites within the cell.
C. Rosendorff, C. Goodman
openaire +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Postgraduate Medicine, 1983
Captopril (Capoten) and minoxidil (Loniten) have recently become generally available for treatment of hypertension, and calcium channel blockers, although not yet officially approved for this indication, clearly have potential as antihypertensive agents. Captopril, the only available inhibitor of angiotensin-converting enzyme, is particularly effective
openaire +3 more sources
Captopril (Capoten) and minoxidil (Loniten) have recently become generally available for treatment of hypertension, and calcium channel blockers, although not yet officially approved for this indication, clearly have potential as antihypertensive agents. Captopril, the only available inhibitor of angiotensin-converting enzyme, is particularly effective
openaire +3 more sources
Clonidine: A new antihypertensive agent
The American Journal of Cardiology, 1971Abstract Intravenous administration of clonidine in hypertensive patients resulted in a short, hypertensive response followed by a prolonged reduction of both systolic and diastolic pressure. The antihypertensive response was associated with a decrease of total forearm blood flow, while the muscle blood flow of the calf was unchanged or moderately ...
Volker Heimsoth +4 more
openaire +3 more sources
Centrally Acting Antihypertensive Agents
Journal of Cardiovascular Pharmacology, 1988In spite of the fact that plasma catecholamine levels, baroreflex activity, and hemodynamic pattern significantly change with age and drugs whose action is mediated via the sympathetic nervous system might be expected to cause different effects, the limited available data suggest that both alpha-methyldopa and clonidine lower blood pressure to a ...
openaire +3 more sources
Vasodilators as Antihypertensive Agents
1982In this chapter, we will analyse the mode of action and therapeutic use of the ‘direct-acting smooth muscle relaxant antihypertensor drugs’. We will include in this class of drugs those antihypertensive compounds which are supposed to relax vascular smooth muscle without interfering with identified cell receptors (adrenergic, dopaminergic, angiotensin ...
M. Worcel, J. C. Gaignault
openaire +2 more sources
New Antihypertensive Agents: Benefit of Treatment
Journal of Cardiovascular Pharmacology, 1992Large-scale end-point trials have demonstrated that antihypertensive treatment reverses the risk of stroke attributable to high blood pressure and probably reduces the incidence of myocardial infarction. Despite this major achievement in therapeutics, substantial goals still need to be achieved.
openaire +3 more sources
Ouabain Antagonists as Antihypertensive Agents
Current Pharmaceutical Design, 2005The evidence that high levels of endogenous ouabain (EO), a closely related isomer of ouabain, are implicated in human hypertension and cardiac hypertrophy and failure stimulated the pharmacological research for developing novel anti-hypertensive agents active as ouabain antagonists.
P. Barassi +7 more
openaire +3 more sources
Chapter 6 Antihypertensive Agents
1990Publisher Summary Cardiovascular disease accounts for more expenditures on health care than any other diagnostic category and hypertension is the most prevalent cardiovascular condition. While unit costs for hypertension treatment are low, aggregate costs are enormous because of the large and growing population of patients who are treated ...
Edward W. Petriilo +2 more
openaire +2 more sources
Antihypertensive Agents in the Dialysis Patient
Current Hypertension Reports, 2019Hypertension and antihypertensive drug utilization are remarkably prevalent in ESRD patients. Management of blood pressure elevation in this population is complicated by many factors, including a multidimensional etiology, challenges in obtaining accurate and appropriately timed blood pressure measurements, highly specific drug dosing requirements, and
Mony Fraer +2 more
openaire +3 more sources
Nebivolol: A new antihypertensive agent
American Journal of Health-System Pharmacy, 2008The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, safety, economic issues, dosage, and place in therapy of nebivolol are reviewed.Nebivolol is a novel, highly selective beta(1)-receptor blocker that causes peripheral vasodilation by increasing the production and release of nitric oxide and decreasing nitric oxide degradation.
Charnelda L. Gray, Uche Anadu Ndefo
openaire +3 more sources