Results 71 to 80 of about 109,974 (359)
Frontiers in Physiology, 2016 Though antihypertensive drugs have been in use for many decades, the mechanisms by which they act chronically to reduce blood pressure remain unclear.
Holly Digne-Malcolm +2 more
doaj +1 more source
Ambulatory blood pressure monitoring in clinical trials with antihypertensive agents [PDF]
, 1995 Ambulatory blood pressure monitoring (ABPM) is being used increasingly for the evaluation of antihypertensive agents in clinical trials. In this brief review several aspects of ABPM are discussed.
Meiracker, A.H. (Anton) van den
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Spontaneous reporting of adverse drug reactions (ADR) after a product has reached the market is essential for drug safety. This study analysed patient ADR reports and compared them with reports from the Japanese Adverse Drug Event Report (JADER) database to identify differences and trends.
Masami Tsuchiya +5 more
wiley +1 more source
Tacrolimus in pediatric renal transplantation [PDF]
, 1996 Tacrolimus was used as the primary immunosuppressive agent in 69 pediatric renal transplantations between December 17, 1989, and June 30, 1995. Children undergoing concomitant or prior liver and/or intestinal transplantation were excluded from analysis ...
Ellis, D +12 more
core +1 more source
Chronopharmacology of antihypertensive agents.
Drug Metabolism and Pharmacokinetics, 1988 There is increasing evidence demonstrating time-dependent changes in effectiveness and toxicity of several agents. Recently we investigated some chronopharmacological aspects of antihypertensive agents such as diuretic, adrenoceptor blocking and calcium channel blocking. We observed that the effects of diuretic agent are greater when it is administered
openaire +3 more sources
Chemistry &Biodiversity, EarlyView.ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban +7 more
wiley +1 more source
Effect of erythropoiesis-stimulating agents on blood pressure in pre-dialysis patients. [PDF]
PLoS ONE, 2013 IntroductionErythropoiesis-Stimulating Agents (ESA) are hypothesized to increase cardiovascular mortality in patients with chronic kidney disease. One of the proposed mechanisms is the elevation of blood pressure (BP) by ESA.
Marit M Suttorp +5 more
doaj +1 more source
, 2004 Hypertension is a rapidly moving clinical field with frequent developments in new pharmacologic agents and management strategies. Perhaps more importantly, there have been substantial improvements in our understanding of how best to use the drugs ...
Farrugia, Emanuel
core
Chemistry &Biodiversity, EarlyView.Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo +3 more
wiley +1 more source
Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. [PDF]
, 2016 ObjectiveTo compare different blood pressure (BP) levels in their association with the risk of renal outcomes in type 1 diabetes and to determine whether an intensive glycemic control strategy modifies this association.Research design and methodsWe ...
Gitelman, Stephen E +5 more
core +2 more sources