Results 81 to 90 of about 111,447 (309)

Impact of Antihypertensive Treatment on Outcomes of Adjuvant Bevacizumab for Ovarian Cancer (IATRO), Results from a Nationwide Emulated Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Antiangiogenic therapy with bevacizumab improves outcomes in ovarian cancer but induces hypertension, leading to major adverse cardiovascular events (MACE). While calcium channel blockers (CCBs) and angiotensin‐converting enzyme inhibitors (ACEi) are recommended for managing bevacizumab‐associated hypertension, their impacts on cancer progression and ...
Floriane Jochum, Élise Dumas, Joe‐Elie Salem, Stéphane Ederhy, Anne‐Sophie Hamy, Lise Lecointre, Enora Laas, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Paul Gougis   +10 more
wiley   +1 more source

Case-control study of stroke and the quality of hypertension control in north west England [PDF]

, 1997
Objective: To examine the risk of stroke in relation to quality of hypertension control in routine general practice across an entire health district. Design: Population based matched case-control study.
Cruickshank, K, Du, X, Holmes, S, McNamee, R, Roberts, N, Saraee, MH, Sourbutts, J, Summers, A, Walton, E   +8 more
core   +2 more sources

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?

British Journal of Pharmacology, EarlyView., 2023
Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley   +1 more source

Tacrolimus in pediatric renal transplantation [PDF]

, 1996
Tacrolimus was used as the primary immunosuppressive agent in 69 pediatric renal transplantations between December 17, 1989, and June 30, 1995. Children undergoing concomitant or prior liver and/or intestinal transplantation were excluded from analysis ...
Ellis, D, Fung, JJ, Gilboa, N, Gritsch, HA, Hakala, TR, Irish, W, Jordan, ML, Lombardozzi-Lane, S, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

Pharmaco-epidemiological aspects of arterial hypertension management in Tomsk Region

Кардиоваскулярная терапия и профилактика, 2005
Aim. To investigate real-word antihypertensive drug therapy in Tomsk City and Region. Material and methods. In January-June 2004, non-organized population of Tomsk City and Region was examined, according to the Regional Program «Arterial Hypertension ...
E. Yu. Turkasova, T. G. Volkova, T. N. Ketova, E. M. Idrisova, O. S. Kobyakova, S. A. Banin, M. F. Chinyaev   +6 more
doaj  

The role of nitric oxide in improving endothelial function andcardiovascular health: focus on nebivolol

Кардиоваскулярная терапия и профилактика, 2011
Although β-blockers have been endorsed by guidelines committees for the treatment of patients with hypertension, particularly those with significant CVD and high CVD risk, there are concerns about conventional β-blockers related to poorer clinical ...
G. L. Bakris, J. N. Basile, T. D. Giles, A. A. Taylor   +3 more
doaj   +1 more source

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, EarlyView.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

ANGIOTENSIN RECEPTOR ANTAGONISTS: GOING WITH THE TIMES

Кардиоваскулярная терапия и профилактика, 2013
This literature review focuses on the angiotensin II receptor antagonists as one of the new and promising classes of antihypertensive medications. Apart from their antihypertensive activity, these agents possess a number of other beneficial effects.
E. O. Taratukhin
doaj   +1 more source