Results 1 to 10 of about 150,094 (202)

Chemical Synthesis, Safety and Efficacy of Antihypertensive Candidate Drug 221s (2,9)

Molecules, 2023
Hypertension is the main risk factor of cardiovascular and cerebrovascular diseases. In this paper, a novel compound known as 221s (2,9), which includes tanshinol, borneol and a mother nucleus of ACEI, was synthesized by condensation esterification ...
Bei Qin, Lili Yu, Rong Wang, Yimei Tang, Yunmei Chen, Nana Wang, Yixin Zhang, Xiong Tan, Kuan Yang, Bo Zhang, Maofang He, Yuzhen Zhang, Yaqi Hu   +12 more
doaj   +1 more source

Narrative update of clinical trials with antihypertensive drugs in children and adolescents

Frontiers in Cardiovascular Medicine, 2022
IntroductionTo date, our knowledge on antihypertensive pharmacological treatment in children and adolescents is still limited because there are few randomized clinical trials (CTs), hampering appropriate management.
Josep Redon, Tomas Seeman, Dénes Pall, Lagle Suurorg, Konstantinos Kamperis, Serap Erdine, Elke Wühl, Giuseppe Mancia   +7 more
doaj   +1 more source

Antihypertensive Drug Use Pattern in a Tertiary Care Hospital of Western Region of Nepal: A Cross-Sectional Study

Journal of Lumbini Medical College, 2023
Introduction: Assessing antihypertensive drug use pattern always plays an important role to mitigate the burden of hypertension and also helps doctors to prescribe the drugs rationally.
Naresh Karki, Kamal Kandel, Pravin Prasad, Jeevan Khanal   +3 more
doaj   +1 more source

Antihypertensive drugs

Pharmacological Research, 2017
Successful treatment of hypertension is possible with limited side effects given the availability of multiple antihypertensive drug classes. This review describes the various pharmacological classes of antihypertensive drugs, under two major aspects: their mechanisms of action and side effects.
Katie Traylor, Holly Gurgle, Kyle Turner, Anna Woods, Kezia Brown, Sidhartha D. Ray   +5 more
  +5 more sources

Effect of patient and treatment factors on persistence with antihypertensive treatment: A population-based study.

PLoS ONE, 2021
PurposeTo analyze patterns of antihypertensive drug use among new users in a Southern European population, and identify patient- and treatment-related factors that influence persistence.MethodsThis is a retrospective observational study of new ...
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, María Jesús Lallana, Javier Armesto, María José Rabanaque   +5 more
doaj   +1 more source

Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment

Frontiers in Medicine, 2022
Hypertension is a leading risk factor for cardiovascular diseases and can reduce life expectancy. Owing to the widespread use of antihypertensive drugs, patients with hypertension have improved blood pressure control over the past few decades.
Hui-Qing Chen, Jin-Yu Gong, Kai Xing, Mou-Ze Liu, Mou-Ze Liu, Huan Ren, Jian-Quan Luo, Jian-Quan Luo   +7 more
doaj   +1 more source

Relationship between doses of antihypertensive drugs and left ventricular mass index changes in hemodialysis patients in a Japanese cohort

Renal Failure, 2021
Left ventricular hypertrophy commonly occurs in dialysis patients and is associated with a risk of developing cardiovascular disease events and all-cause mortality.
Fumiya Kitamura, Makoto Yamaguchi, Takayuki Katsuno, Hironobu Nobata, Shiho Iwagaitsu, Hirokazu Sugiyama, Hiroshi Kinashi, Shogo Banno, Masahiko Ando, Yoko Kubo, Yasumasa Kawade, Iwashima Shigejiro, Yutaka Ito, Takuji Ishimoto, Yasuhiko Ito   +14 more
doaj   +1 more source

Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium [PDF]

, 2015
Background Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke.
Arnett, Donna, Avery, Christy L., Bis, Joshua C., Boerwinkle, Eric, Brody, Jennifer A., Buckley, Brendan M., Chen, Yii-Der Ida, Cummings, Steven R., Cupples, L. Adrienne, Davis, Barry R., de Craen, Anton J. M., Demissie, Serkalem, Eckfeldt, John H., Evans, Daniel S., Ford, Ian, Franco, Oscar H., Gudnason, Vilmundur, Harris, Tamara B., Heckbert, Susan R., Hofman, Albert, Ikram, M. Arfan, Irvin, Ryan, Jukema, J. Wouter, Krijthe, Bouwe P., Lange, Leslie A., Launer, Lenore J., Li, Xiaohui, Liu, Yongmei, Lumley, Thomas, Musani, Solomon K., Post, Wendy, Psaty, Bruce M., Quibrera, P. Miguel, Rotter, Jerome I., Sattar, Naveed, Sitlani, Colleen, Slagboom, P. Eline, Smith, Albert Vernon, Smith, Nicholas L., Sotoodehnia, Nona, Stott, David J., Stricker, Bruno H., Stürmer, Til, Sun, Fangui, Taylor, Herman A., Taylor, Kent D., Tranah, Gregory J., Trompet, Stella, Uitterlinden, Andre G., Vasan, Ramachandran S., Westendorp, Rudi, Whitsel, Eric A., Wiggins, Kerri L., Wilson, James G.   +53 more
core   +7 more sources

The impact of “4 + 7” volume-based drug procurement on the volume, expenditures, and daily costs of antihypertensive drugs in Shenzhen, China: an interrupted time series analysis

BMC Health Services Research, 2021
Background In 2019, Chinese government launched a nationwide volume-based drug procurement aiming at reducing drug prices and saving drug costs through economies of scale, which aroused widespread attention.
Ying Yang, Ruiwen Tong, Shicheng Yin, Lining Mao, Luxinyi Xu, Siyu Hao, Zongfu Mao   +6 more
doaj   +1 more source

Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chinese population from over one million prescriptions [PDF]

, 2008
Hypertension is an alarming public health problem among Chinese. The present study evaluated the prescribing patterns, discontinuation and switching profiles of antihypertensive agents and their associated factors in one Hong Kong Chinese population ...
A Fretheim, A T Lam, BM Cheung, G Onder, H Fung, H Mori, J Ma, J Y Jiang, M C S Wong, MCS Wong, S Griffiths, S W Mercer, T Walley, YH Yuen, Z Kabir   +14 more
core   +1 more source