Results 1 to 10 of about 3,902,984 (310)

Chemical Synthesis, Safety and Efficacy of Antihypertensive Candidate Drug 221s (2,9) [PDF]

Molecules, 2023
Hypertension is the main risk factor of cardiovascular and cerebrovascular diseases. In this paper, a novel compound known as 221s (2,9), which includes tanshinol, borneol and a mother nucleus of ACEI, was synthesized by condensation esterification ...
Bei Qin, Lili Yu, Rong Wang, Yimei Tang, Yunmei Chen, Nana Wang, Yixin Zhang, Xiong Tan, Kuan Yang, Bo Zhang, Maofang He, Yuzhen Zhang, Yaqi Hu   +12 more
doaj   +2 more sources

Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment

Frontiers in Medicine, 2022
Hypertension is a leading risk factor for cardiovascular diseases and can reduce life expectancy. Owing to the widespread use of antihypertensive drugs, patients with hypertension have improved blood pressure control over the past few decades.
Hui-Qing Chen, Jin-Yu Gong, Kai Xing, Mou-Ze Liu, Mou-Ze Liu, Huan Ren, Jian-Quan Luo, Jian-Quan Luo   +7 more
doaj   +2 more sources

The impact of “4 + 7” volume-based drug procurement on the volume, expenditures, and daily costs of antihypertensive drugs in Shenzhen, China: an interrupted time series analysis

BMC Health Services Research, 2021
Background In 2019, Chinese government launched a nationwide volume-based drug procurement aiming at reducing drug prices and saving drug costs through economies of scale, which aroused widespread attention.
Ying Yang, Ruiwen Tong, Shicheng Yin, Lining Mao, Luxinyi Xu, Siyu Hao, Zongfu Mao   +6 more
doaj   +2 more sources

Antihypertensive drug use and prostate cancer-specific mortality in Finnish men.

PLoS ONE, 2020
The aim of this study was to investigate pre- and post-diagnostic use of antihypertensive drugs on prostate cancer (PCa)-specific survival and the initiation of androgen deprivation therapy (ADT).
Aino Siltari, Teemu J Murtola, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen   +5 more
doaj   +2 more sources

Impact of COVID-19 epidemic on antihypertensive drug treatment disruptions: results from a nationwide interrupted time-series analysis [PDF]

Frontiers in Pharmacology, 2023
Background: The COVID-19 epidemic has disrupted care and access to care in many ways. It was accompanied by an excess of cardiovascular drug treatment discontinuations.
Clément Mathieu, Julien Bezin, Julien Bezin, Antoine Pariente, Antoine Pariente   +4 more
doaj   +2 more sources

Extensive ischemic gastroduodenal necrosis caused by antihypertensive drug overdose in a young man. [PDF]

Clin Case Rep, 2023
Yuan T, Sun J, Ma Q.
europepmc   +3 more sources

Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level [PDF]

HYPERTENSION, 2017
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi   +44 more
openalex   +2 more sources

Antihypertensive drug effects on long-term blood pressure: an individual-level data meta-analysis of randomised clinical trials

Heart, 2022
Objective Evidence from randomised trials of pharmacological treatments on long-term blood pressure (BP) reduction is limited. We investigated the antihypertensive drug effects on BP over time and across different participant characteristics.
D. Canoy, E. Copland, M. Nazarzadeh, R. Ramakrishnan, Ana-Catarina Pinho-Gomes, A. Salam, J. Dwyer, F. Farzadfar, J. Sundström, M. Woodward, B. Davis, K. Rahimi   +11 more
semanticscholar   +1 more source

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis

PLoS Medicine, 2022
Background Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk.
J. Yarmolinsky, V. Díez-Obrero, T. Richardson, M. Pigeyre, J. Sjaarda, G. Paré, V. Walker, E. Vincent, V. Y. Tan, M. Obón-Santacana, D. Albanes, J. Hampe, A. Gsur, H. Hampel, R. Pai, M. Jenkins, S. Gallinger, G. Casey, Wei Zheng, C. Amos, George Davey Smith, R. M. Martin, V. Moreno   +22 more
semanticscholar   +1 more source

Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study.

JAMA psychiatry, 2021
Importance Observational studies have reported associations between antihypertensive medication and psychiatric disorders, although the reported direction of association appears to be dependent on drug class.
S. Chauquet, Zhihong Zhu, M. O’Donovan, J. Walters, N. Wray, Sonia H. Shah   +5 more
semanticscholar   +1 more source