Results 41 to 50 of about 93,278 (263)

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

Hepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef, Milan J. Sonneveld, Maryam Kavousi, M. Arfan Ikram, Robert A. de Man, Robert J. de Knegt   +5 more
wiley   +1 more source

Decreased Expression of Angiotensin II Type 1 and Type 2 Receptors in the Brain After Long-Term Administration of Antihypertensive Drugs in Stroke-Prone Spontaneously Hypertensive Rat

Journal of Pharmacological Sciences, 2008
The present study examined the levels of Angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of ...
Yayoi Nishida, Yasuo Takahashi, Megumi Sugahara-Kobayashi, Kouichi Ishikawa, Satoshi Asai   +4 more
doaj   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Antihypertensive Treatment Patterns in CKD Stages 3 and 4: The CKD-REIN Cohort Study

Kidney Medicine
Rationale & Objective: Blood pressure (BP) control is essential for preventing cardiorenal complications in chronic kidney disease (CKD), but most patients fail to reach BP target.
Margaux Costes-Albrespic, Sophie Liabeuf, Solène Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Oriane Lambert, Ziad A. Massy, Bénédicte Sautenet, Natalia Alencar de Pinho, Natalia Alencar de Pinho, Christian Combe, Denis Fouque, Luc Frimat, Aghilès Hamroun, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Abdou Omorou, Christophe Pascal, Roberto Pecoits-Filho, Bénédicte Stengel, Céline Lange, Oriane Lambert, Marie Metzger   +28 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

The Risk of Cardiovascular Diseases for Shift Workers in the Prospective Heinz Nixdorf Recall Study

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Shift work can disrupt circadian rhythms and is postulated to play a role in cardiovascular diseases (CVD). In the German prospective population‐based Heinz Nixdorf Recall Study, we analyzed longitudinal associations between shift work and night‐shift work with CVD.
Katharina Wichert, Sylvia Rabstein, Raimund Erbel, Lewin Eisele, Marina Arendt, Nico Dragano, Karl‐Heinz Jöckel, Thomas Behrens   +7 more
wiley   +1 more source

Antihypertensive treatment for hypertensive patients with heart failure using real-world Japanese data: subanalysis of the Retrospective study of antihypertensives for lowering blood pressure (REAL) study

Clinical and Experimental Hypertension, 2020
The number of patients with heart failure (HF) is rapidly increasing. Although hypertension is related to onset of HF, antihypertensive treatment status for these patients has not been fully examined.
Mitsuru Ohishi, Takuo Yoshida, Nobuhiro Nishigaki, Akinori Oh, Yukio Shimasaki   +4 more
doaj   +1 more source

Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients

Cells, 2021
(1) Background: Recently, influences of antihypertensive treatment on the renin–angiotensin–aldosterone system (RAAS) has gained attention, regarding a possible influence on inflammatory and anti-inflammatory pathways.
Annina S. Vischer, Gabriela M. Kuster, Raphael Twerenbold, Otmar Pfister, Qian Zhou, Andrea Villiger, Marko Poglitsch, Stephan Krähenbühl, Michael Mayr, Stefan Osswald, Manuel Haschke, Thilo Burkard   +11 more
doaj   +1 more source