Results 161 to 170 of about 1,146,821 (287)

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis. [PDF]

Int J Genomics
Shi W, Liu S, Wu X, Cheng W, Jia X, Hu Z.   +5 more
europepmc   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

A genetics-guided integrative framework for drug repurposing: identifying antihypertensive drugs for type 2 diabetes. [PDF]

NPJ Drug Discov
Zhong X, Wei Q, Tiwari A, Wang Q, Tan Y, Chen R, Yan Y, Cox NJ, Li B.   +8 more
europepmc   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Effectiveness of antihypertensive drugs for secondary prevention of ischaemic stroke: a nationwide historic cohort study. [PDF]

BMJ Open
Perrier J, Gabet A, Olié V, Pariente A, Tzourio C, Bezin J.   +5 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Association between GP characteristics and prescription patterns for antihypertensive drugs: a secondary data analysis in Normandy, France. [PDF]

BMC Prim Care
Rabiaza A, Massenet M, Legrand F, Kuhn F, Duver S, Legallois D, Dolladille C, Alexandre J, Bas FL, Delpech R, Humbert X.   +10 more
europepmc   +1 more source

Long‐Term Outcomes of Omniflow II and BioIntegral Xenografts for Open Aortic Reconstruction in Predominantly Infected Settings: A Multicenter Cohort Study

World Journal of Surgery, EarlyView.
Evidence surrounding conduit selection for open in situ aortic reconstruction remains limited, particularly for xenograft use in infected settings. We evaluated long‐term outcomes after open aortic and aorto‐iliac reconstruction using BioIntegral No‐React bovine grafts and Omniflow II biosynthetic grafts in patients unsuitable for autologous vein ...
Tijmen W. Kraai, Eline I. Reinders Folmer, Barzi Gareb, David J. Liesker, Ben R. Saleem, Clark J. Zeebregts, Vascular Xenograft Research Group   +6 more
wiley   +1 more source

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta-analysis. [PDF]

Psychiatry Clin Neurosci
Carnaval T, Bui M, Villoria J, Rodríguez D, Menchón JM, Ciruela F, Videla S.   +6 more
europepmc   +1 more source