Results 41 to 50 of about 157,060 (341)

Toxicity Profiling and In Vivo Metabolism of Danshensu-Derived Novel Antihypertensive Candidate 221s (2,9)

open access: yesToxins
Compound 221s (2,9) is a novel antihypertensive drug candidate synthesized utilizing danshensu, borneol, and proline by using the strategy of combinatorial molecular chemistry.
Yunmei Chen   +5 more
doaj   +1 more source

A Flexible Regimen of Combination Antihypertensive Therapy for Lower Blood Pressure to the Lower Target Level. Viewpoint of Cardiologist and Clinical Pharmacologist

open access: yesРациональная фармакотерапия в кардиологии, 2019
Modern tactics of antihypertensive therapy with fixed dose combination or with free combinations of antihypertensive drugs are reviewed in the article. The evidence that a flexible regimen of combination antihypertensive therapy is more reasonable in the
S. R. Gilyarevskiy   +4 more
doaj   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran   +17 more
wiley   +1 more source

Resistant and undertreated hypertension in patients with chronic kidney disease: data from the PATRIOTIC survey

open access: yesClinical and Experimental Hypertension, 2018
Background: Hypertension is prevalent in chronic kidney disease (CKD), but the control of hypertension is suboptimal. We reported the prevalence and characteristics of resistant and undertreated hypertension based on a nationwide survey aiming to improve
Ying Zheng   +8 more
doaj   +1 more source

Prescription pattern of antihypertensive drugs in Family Practice Clinics at Jordan University Hospital

open access: yesMedicine Science, 2013
The present study represents the current prescribing trend for antihypertensive drugs in family medicine clinics at Jordan University Hospital in Jordan. The study sample involved 416 male and female hypertensive Jordanian patients.
Essam Al-Drabah   +3 more
doaj   +1 more source

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

open access: yesHepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef   +5 more
wiley   +1 more source

紫苏籽油的抗衰老作用及机制探究 Anti-aging effect and mechanisms of perilla seed oil

open access: yesZhongguo youzhi
旨在为紫苏籽油的开发利用提供理论依据,以D-半乳糖(500 mg/kg)在小鼠颈背部皮下连续注射4周建立小鼠衰老模型后,将小鼠随机分为模型对照组(生理盐水)、阳性对照组(维生素C 200 mg/kg)和紫苏籽油高(5 mL/kg)、中(2.5 mL/kg)、低(1.25 mL/kg)剂量组,连续灌胃4周,记录小鼠体质量及行为变化,通过转棒法和金属网法检测小鼠的协调运动能力,测定小鼠主要脏器(脑、胸腺、脾脏)指数以及小鼠血清和脑组织匀浆中谷胱甘肽过氧化物酶(GSH-Px)活力和丙二醛(MDA)含量 ...
王荣1,2,3,王娜娜1,2,3,杨宽1,2,3,刘自群1,秦蓓1,2,3 WANG Rong1,2,3,WANG Nana1,2,3, YANG Kuan1,2,3, LIU Ziqun1,QIN Bei1,2,3
doaj   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

open access: yesHepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef   +2 more
wiley   +1 more source

Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]

open access: yes, 2017
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio   +5 more
core   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song   +6 more
wiley   +1 more source

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