Results 41 to 50 of about 67,136 (328)

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

Hepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef, Milan J. Sonneveld, Maryam Kavousi, M. Arfan Ikram, Robert A. de Man, Robert J. de Knegt   +5 more
wiley   +1 more source

A Vector Theory of Assessing Clinical Trials: An Application to Bioequivalence

Journal of Cardiovascular Development and Disease
A novel idea is introduced regarding the statistical comparisons of endpoints in clinical trials. Currently, the (dis)similarity of measured endpoints is not assessed.
Vangelis D. Karalis
doaj   +1 more source

Polypills for Primary Prevention of Cardiovascular Disease: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine, 2022
PurposeTo evaluate the effect of polypills on the primary prevention of cardiovascular (CV) events using data from clinical trials.MethodsWe searched PubMed, Web of Science, EBSCO, and SCOPUS throughout May 2021.
Omneya A. Kandil, Karam R. Motawea, Merna M. Aboelenein, Jaffer Shah   +3 more
doaj   +1 more source

Improving prescribing practices in primary care: A randomised trial and economic analysis of a multicomponent intervention showed small, but important, gains [PDF]

, 2006
Del Mar discusses the implications of the RaPP trial, a cluster RCT of a multi-component intervention to improve prescribing of antihypertensive and cholesterol-lowering drugs in primary ...
Del Mar, Chris
core   +3 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Association of Calcium Channel Blocker Use With Intradialytic Hypotension in Maintenance Hemodialysis

Kidney International Reports
Introduction: Calcium channel blockers (CCBs) are common antihypertensive agents among patients receiving hemodialysis (HD). Despite this, the association of CCBs with intradialytic hypotension (IDH), an important adverse outcome that is associated with ...
Armida Lefranc Torres, Simon Correa, Finnian R. Mc Causland   +2 more
doaj   +1 more source

Blood pressure, lipids, and obesity are associated with reteinopathy - The Hoorn study [PDF]

, 2002
OBJECTIVE - To study potential risk factors for retinopathy in diabetic and nondiabetic individuals. RESEARCH DESIGN AND METHODS - The Hoorn Study is a population-based study including 2,484 50- to 74-year-old Caucasians.
A. C. Moll, Aldington, B. C.P. Polak, Beks, C. D.A. Stehouwer, Chaturvedi, Chew, G. Nijpels, Gabir, H. A. van Leiden, Harding, Hoogeveen, J. M. Dekker, Klein, Klein, Klein, Klein, Klein, Kohner, Kohner, L. M. Bouter, Moss, Nelson, R. J. Heine, Rajala, Stratton, UK Prospective Diabetes Study Group, West, Yu   +28 more
core   +3 more sources

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over

Arthritis Care &Research, EarlyView.
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard, Cammie Tran, Hans G. Schneider, Flavia M. Cicuttini, Anita E. Wluka, Ego Seeman, Johannes T. Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P. Q. Clark, Daniel Clayton‐Chubb, Andrew M. Tonkin, Lawrence J. Beilin, Robyn L. Woods, John J. McNeil   +15 more
wiley   +1 more source

Antihypertensive therapy during pregnancy: the prescription pattern in Italy

Frontiers in Pharmacology
Drug use during pregnancy should be evidence-based and favor the safest and most appropriate prescription. The Italian Medicines Agency (AIFA) coordinates a network focusing on monitoring medication use in pregnancy.
Anna Locatelli, Nicolò Bellante, Gianluca Donatiello, Filomena Fortinguerra, Valeria Belleudi, Francesca R. Poggi, Serena Perna, Francesco Trotta   +7 more
doaj   +1 more source