Results 101 to 110 of about 80,047 (217)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]

, 2012
\ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Lutambi Angelina M, Khatib, R. A., Rashid A Khatib, Masanja Irene M, Khatib Rashid A, Irene M Masanja, Masanja, Irene M, Lutambi, A. M., Angelina M Lutambi, Lutambi, Angelina M, Masanja, I. M., Khatib, Rashid A   +11 more
core   +2 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Malaria control strategies emphasize the need for prompt and effective treatment of malaria episodes. To increase treatment efficacy, Tanzania changed its first-line treatment from chloroquine to sulphadoxine-pyrimethamine (SP) in 2001.
Catherine Goodman, Alexander Schulze, Makemba, Ahmed, Nathan, R., Hetzel, Manuel W, Christian Lengeler, Msechu, June J., Goodman, C., Manuel W Hetzel, Nathan, Rose, Schulze, A., Kachur, S.P., Hassan Mshinda, Brigit Obrist, Rose Nathan, S Patrick Kachur, Mshinda, Hassan, Lengeler, C., Ahmed Makemba, Lengeler, Christian, June J Msechu, Makemba, A., Msechu, J.J., Kachur, S. Patrick, Msechu, June J, Obrist, Brigit, Obrist, B., Goodman, Catherine, Mshinda, H., Kachur, S Patrick, Schulze, Alexander, Hetzel, Manuel W.   +31 more
core   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Therapeutic Potential of Iridoid Derivatives: Patent Review

Inventions, 2019
Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency.
Hidayat Hussain, Ivan R. Green, Muhammad Saleem, Muhammad Liaquat Raza, Mamona Nazir   +4 more
doaj   +1 more source

Adherence of community caretakers of children to pre-packaged antimalarial medicines (HOMAPAK) among internally displaced people in Gulu district, Uganda. [PDF]

, 2006
BACKGROUND: In 2002, home-based management of fever (HBMF) was introduced in Uganda, to improve access to prompt, effective antimalarial treatment of all fevers in children under 5 years.
Opwonya, John, Opwonya John, Kolaczinski, Jan H, Kolaczinski Jan H, Meek, Sylvia, Meek Sylvia, Collins Andrew, Collins, Andrew, Jan H Kolaczinski, Ojok, Naptalis, Sylvia Meek, Andrew Collins, Naptalis Ojok, John Opwonya, Ojok Naptalis   +14 more
core   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Investigations of amination reactions on an antimalarial 1,2,4-triazolo[4,3-a]pyrazine scaffold

Beilstein Journal of Organic Chemistry
1,2,4-Triazolo[4,3-a]pyrazines have previously been explored by the Open Source Malaria project as potent in vitro and in vivo antimalarial drug leads.
Henry S. T. Smith, Ben Giuliani, Kanchana Wijesekera, Kah Yean Lum, Sandra Duffy, Aaron Lock, Jonathan M. White, Vicky M. Avery, Rohan A. Davis   +8 more
doaj   +1 more source