Results 91 to 100 of about 51,644 (231)
Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress
Plant, Cell &Environment, EarlyView.ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee +5 more
wiley +1 more source
Tropical Medicine &International Health, EarlyView.ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves +3 more
wiley +1 more source
Structural Characterization of 7-Chloro-4-(4-methyl-1-piperazinyl)quinoline Monohydrate
MolbankThe crystal structure of the hydrated form of 7-chloro-4-(4-methyl-1-piperazinyl)quinoline (BPIP) was determined by single-crystal X-ray diffraction analysis.
Silvia Rizzato, Francesco Marinoni
doaj +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz +17 more
wiley +1 more source
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig +14 more
wiley +1 more source
Synthesis and Photolysis Properties of a New Chloroquine Photoaffinity Probe
MoleculesA new chloroquine-derived photoaffinity probe has been prepared by a convergent synthesis from derivative of 4,7-dichloroquinoline and N1,N1-diethyl-N4-methylpentane.
Benita Kapuku, D. Scott Bohle
doaj +1 more source
The use of antimalarial drugs.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974 A general review is given of the antimalarial drugs currently available and in common use, with special reference to those found to be of most benefit in Southern Africa.S. Afr. Med. J., 48, 1314 (1974)
openaire +3 more sources
Actinomycin Derivatives: Structural Diversification and Biological Activities
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova +4 more
wiley +1 more source