Results 91 to 100 of about 80,047 (217)

Hybrid Peptide-Alkoxyamine Drugs: A Strategy for the Development of a New Family of Antiplasmodial Drugs

Molecules
The emergence and spread of drug-resistant Plasmodium falciparum parasites shed a serious concern on the worldwide control of malaria, the most important tropical disease in terms of mortality and morbidity.
Ange W. Embo-Ibouanga, Michel Nguyen, Lucie Paloque, Mathilde Coustets, Jean-Patrick Joly, Jean-Michel Augereau, Nicolas Vanthuyne, Raphaël Bikanga, Naomie Coquin, Anne Robert, Gérard Audran, Jérôme Boissier, Philippe Mellet, Françoise Benoit-Vical, Sylvain R. A. Marque   +14 more
doaj   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

The antimalarial potential of Ugandan traditional medicines : a study of six plants used to treat malaria symptoms [PDF]

, 2003
Bibliography: leaves 102-122.The study investigates the antimalarial potential of six Ugandan traditional medicinal plants Senecfo discifolius oliv, Senecio stuhlmannii, Indigofera emarginella steud. Ex A. Rich, Aspifia africana (Pers) C.D.
Waako, Paul
core   +1 more source

In vitro and in vivo antischistosomal activity of ferroquine derivatives [PDF]

, 2014
Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development.
Riccardo Rubbiani, Christophe Biot, Rubbiani, Riccardo, Jennifer Keiser, Keiser, Jennifer, Gasser, Gilles, Gilles Gasser, Vargas, Mireille, Biot, Christophe, Mireille Vargas   +9 more
core   +1 more source

The effect of mefloquine dose on outcome of uncomplicated falciparum malaria treated with artesunate-mefloquine: a WWARN systematic review and individual patient data meta-analysis

Malaria Journal
Introduction A combination of mefloquine associated with artesunate (AS-MQ) was the first artemisinin-based combination therapy (ACT) to be used widely for acute uncomplicated P. falciparum malaria.
The WWARN AS-MQ Dose Impact Study Group
doaj   +1 more source

Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children. [PDF]

, 2007
BACKGROUND: Presumptive treatment of malaria in febrile children is widely advocated in Africa. This may occur in the absence of diagnostic testing or even when diagnostic testing is performed but fails to detect malaria parasites. Such over-treatment of
Staedke, Sarah, Denise Njama-Meya, Tamara D Clark, Moses R Kamya, Sarah Staedke, Nzarubara, Bridget, Njama-Meya, Denise, Clark, Tamara D, Grant Dorsey, Dorsey, Grant, Bridget Nzarubara, Kamya, Moses R, Staedke Sarah, Njama-Meya Denise, Clark Tamara D, Nzarubara Bridget, Dorsey Grant, Kamya Moses R   +17 more
core   +1 more source

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

JSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune, Amare Bitew Mekonnen, Getahun Yemata   +2 more
wiley   +1 more source

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids

Molecules, 2016
Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating ...
Birgit Viira, Thibault Gendron, Don Antoine Lanfranchi, Sandrine Cojean, Dragos Horvath, Gilles Marcou, Alexandre Varnek, Louis Maes, Uko Maran, Philippe M. Loiseau, Elisabeth Davioud-Charvet   +10 more
doaj   +1 more source

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Bajunirwe, Francis, Piola, P, Piola, Patrice, Taylor, W R J, Babigumira, J, Kyomuhendo, J, Taylor, Walter R. J., Checchi, Francesco, Babigumira, Joseph, Ruzagira, E, Kyomuhendo, Juliet, Taylor, Walter RJ, Ferradini, Laurent, Kiguli, James, Kiguli, J, Ferradini, L, Fogg, C, Fogg, Carole, Bajunirwe, F, Guthmann, J P, Ruzagira, Eugene, Biraro, S, Kigozi, Isaac, Checchi, F, Guthmann, Jean-Paul, Biraro, Samuel, Grandesso, Francesco, Grandesso, F, Kigozi, I, Kyomuhendo Juliet, Laurent Ferradini, Francis Bajunirwe, Walter RJ Taylor, Carole Fogg, Eugene Ruzagira, Isaac Kigozi, Taylor Walter RJ, Ruzagira Eugene, Biraro Samuel, Piola Patrice, Fogg Carole, Francesco Checchi, Samuel Biraro, Babigumira Joseph, Kigozi Isaac, James Kiguli, Grandesso Francesco, Joseph Babigumira, Kiguli James, Jean-Paul Guthmann, Ferradini Laurent, Patrice Piola, Guthmann Jean-Paul, Francesco Grandesso, Checchi Francesco, Juliet Kyomuhendo, Bajunirwe Francis   +56 more
core   +1 more source

Paediatric Melanonychia: Diagnosis and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Longitudinal melanonychia (LM) in children presents unique diagnostic and management challenges that cannot be adequately addressed by applying adult‐based criteria. Unlike in adults, there are no validated clinical, dermoscopic or histopathologic criteria for predicting nail unit melanoma in the paediatric population.
Angela J. Jiang, Erika Koh, Je‐Ho Mun, Dong‐Youn Lee, Matilde Iorizzo, Adam I. Rubin   +5 more
wiley   +1 more source