Results 71 to 80 of about 80,047 (217)

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, EarlyView.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Pharmaceutical Management and Prescribing Pattern of Antimalarial Drugs in the Public Health Facilities in Dar-es-salaam, Tanzania [PDF]

, 2011
Despite the efforts of minimizing utilization of limited financial resources in Tanzania, there are still some factors that affect the whole system of supply chain of antimalarial medicines.
Silumbe, Richard S
core  

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

In Silico Studies of Four Compounds of Cecropia obtusifolia against Malaria Parasite

Molecules, 2023
Malaria is a disease that affects many people in the world. In Mexico, malaria remains an active disease in certain regions, particularly in the states of Chiapas and Chihuahua.
Carlos Alberto Lobato-Tapia, Yolotl Moreno-Hernández, Zendy Evelyn Olivo-Vidal   +2 more
doaj   +1 more source

Artemisinin antimalarials: preserving the "magic bullet" [PDF]

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
core   +1 more source

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, EarlyView.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core   +1 more source

Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania. [PDF]

, 2007
BACKGROUND\ud \ud Tanzania switched the antimalarial first line to sulphadoxine-pyrimethamine (SP) in 2001 from ineffective chloroquine (CQ). By 2003 higher levels of SP resistance were recorded, prompting an urgent need for replacing the first line drug
Mugittu, Kefas, Abdulla Salim, Mugittu Kefas, Abdulla, Salim, Sumari Deborah, Mandike, Renata, Mandike Renata, Mwita, Alex, Kabanywanyi Abdunoor M, Kabanywanyi, Abdunoor M, Sumari, Deborah, Mwita Alex   +11 more
core   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Evidence basis for antimalarial policy change in Sierra Leone: five in vivo efficacy studies of chloroquine, sulphadoxine-pyrimethamine and amodiaquine [PDF]

, 2005
OBJECTIVES: To provide nationally relevant information on the antimalarial efficacy of chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ) in Sierra Leone, with a view to updating antimalarial policy in the country.
Sierra Leone Antimalarial, Williams, A, Roddy, Paul, Ranford-Cartwright, L, Durand, Rémy, de Lamotte, N, Pinoges, Loretxu, Kamara, Sarian, Danks, A, de Smet, M, Checchi, Francesco, Lamotte, Nadine de, Williams, Arthur, Durand, R, Morineau, Guy, Kamara, S, Smet, Martin, Pinoges, L, Durand, M, Hora, Bona, Morineau, G, Hora, B, Oloo, Aggrey, Sierra Leone Antimalarial Efficacy Study Collaboration, Heinzelmann, Annette, Wurie, A R, Baerwaldt, T, Checchi, F, Roddy, P, Baerwaldt, Tim, Ranford-Cartwright, Lisa, Oloo, A, Wurie, AR, Sierra Leone Antimalarial,, Heinzelmann, A, Smet, M, Danks, Alison, Wurie, Abdul Rahman, Lamotte, N   +38 more
core   +1 more source