Results 51 to 60 of about 80,047 (217)

New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria [PDF]

Journal of the Serbian Chemical Society, 2013
Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs ...
Tot Mikloš, Opsenica Dejan M., Mitrić Milena, Burnett James C., Gomba Laura, Bavari Sina, Šolaja Bogdan A.   +6 more
doaj   +1 more source

The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca²⁺ Homeostasis by Targeting a Unique Ion Channel

Pharmaceutics, 2022
Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international collaborative team focuses on developing multistage antimalarials that exhibit novel mechanisms of action.
Yash Gupta, Neha Sharma, Snigdha Singh, Jesus G. Romero, Vinoth Rajendran, Reagan M. Mogire, Mohammad Kashif, Jordan Beach, Walter Jeske, Poonam, Bernhards R. Ogutu, Stefan M. Kanzok, Hoseah M. Akala, Jennifer Legac, Philip J. Rosenthal, David J. Rademacher, Ravi Durvasula, Agam P. Singh, Brijesh Rathi, Prakasha Kempaiah   +19 more
doaj   +1 more source

Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies [PDF]

, 2010
Includes bibliographical references.Malaria remains one of the most devastating tropical diseases, with staggering infection and mortality statistics. Over 200 million clinical cases of malaria (resulting in 1 - 3 million deaths) are reported annually ...
Guantai, Eric
core   +1 more source

Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Malaria Journal, 2019
Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment in low transmission areas. However, uptake of this recommendation has
Jaishree Raman, Elizabeth Allen, Lesley Workman, Aaron Mabuza, Hendrik Swanepoel, Gillian Malatje, John Frean, Lubbe Wiesner, Karen I. Barnes   +8 more
doaj   +1 more source

Bioassay-Guided Fractionation with Antimalarial and Antimicrobial Activities of Paeonia officinalis

Molecules, 2022
Bioassay-guided fractionation technique of roots of Paeonia officinalis led to isolation and structure elucidation of seven known compounds, including four monoterpene glycosides: lactiflorin (1), paeoniflorin (4), galloyl paeoniflorin (5), and (Z)-(1S ...
Mamdouh Nabil Samy, Basma Khalaf Mahmoud, Nourhan Hisham Shady, Usama Ramadan Abdelmohsen, Samir Anis Ross   +4 more
doaj   +1 more source

The differences of parasitemia in Plasmodium berghei infected mice treated with extract of mango parasite leaves with Artemisinin combination

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2023
Malaria is a disease transmitted through the bite of a female Anopheles mosquito caused by the Plasmodium parasite. Plasmodium has been reported to become resistant to artemisinin.
Muhammad Zulkifly Tasman, Heny Arwati, Nurina Hasanatuludhhiyah, Puspa Wardhani   +3 more
doaj   +1 more source

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +1 more source

Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia‐Pacific Lupus Collaboration Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective This research article aims to describe the prevalence, associations, and health‐related quality of life (HRQoL) impact of mucocutaneous features of systemic lupus erythematosus (SLE). Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analyzed (2013–2021).
Amanda M. Saracino, Yanjie Hao, Dylan Hansen, Yi‐Hsing Chen, Alberta Hoi, Vera Golder, Jiacai Cho, Aisha Lateef, Worawit Louthrenoo, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Chak Sing Lau, Shirley Chan, Zhanguo Li, Hai‐hong Yao, Sargunan Sockalingam, B. M. D. B. Basnayake, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Jun Kikuchi, Yuko Kaneko, Tsutomu Takeuchi, Madelynn Chan, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Geraldine Hassett, Kristine Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Michael Tee, Cherica Tee, Naoaki Ohkubo, Yoshiya Tanaka, Rangi Kandane‐Rathnayake, Eric Morand, Shereen Oon, Mandana Nikpour   +42 more
wiley   +1 more source

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review

Malaria Journal, 2017
Background Considering the uncertainty of safety of anti-malarial drugs in pregnancy, efficacy studies are one of the few sources of clinical safety data.
Makoto Saito, Mary Ellen Gilder, François Nosten, Philippe J. Guérin, Rose McGready   +4 more
doaj   +1 more source

Quality of antimalarial drugs and antibiotics in Papua New Guinea : a survey of the health facility supply chain [PDF]

, 2014
Poor-quality life-saving medicines are a major public health threat, particularly in settings with a weak regulatory environment. Insufficient amounts of active pharmaceutical ingredients (API) endanger patient safety and may contribute to the ...
Betuela Inoni, Davis, T., Page-Sharp Madhu, Betuela, I., Page-Sharp, Madhu, Bala, Nancy, Bala Nancy, Manuel W Hetzel, Timothy M E Davis, Evelyn K Lavu, Pulford Justin, Lavu, Evelyn K., Nancy Bala, Nancy Bala (563875), Hetzel Manuel W., Davis Timothy M. E., Madhu Page-Sharp (563874), Evelyn K. Lavu (563877), Davis, Timothy M. E., Lavu Evelyn K., Justin Pulford, Lavu, E., Bala, N., Pulford, J., Madhu Page-Sharp, Betuela, Inoni, Inoni Betuela, Hetzel, M., Hetzel, Manuel W., Pulford, Justin, Justin Pulford (563876), Inoni Betuela (67110), Timothy M. E. Davis (112260), Manuel W. Hetzel (563873)   +33 more
core   +2 more sources