Results 31 to 40 of about 80,047 (217)

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
Background In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended ...
Rebecca F. Grais, Ibrahim M. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, Celine Langendorf, Alfred Amambua-Ngwa, Umberto D’Alessandro, Philippe J. Guérin, Thierry Fandeur, Carol H. Sibley   +10 more
doaj   +1 more source

Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance

Frontiers in Pediatrics, 2022
Malaria infection in pregnancy can lead to adverse outcomes for both the pregnant person and fetus. The administration of intermittent preventative therapy (IPTp) with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) improves outcomes, including
Sesh A. Sundararaman, Audrey R. Odom John   +1 more
doaj   +1 more source

Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. [PDF]

, 2008
BACKGROUND: Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Denise Njama-Meya, Moses R Kamya, Sarah G Staedke, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yau, Vincent M, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Yau Vincent M, Nzarubara, Bridget, Vincent M Yau, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Talisuna Ambrose O   +32 more
core   +1 more source

The Vivax Surveyor: Online mapping database for Plasmodium vivax clinical trials

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Introduction: Recurrent P. vivax infections are associated with significant morbidity and mortality. Although radical cure can reduce recurrent infection, it is confounded by antimalarial resistance and the lack of safe and effective hypnozoitocidal ...
R.J. Commons, K. Thriemer, G. Humphreys, I. Suay, C.H. Sibley, P.J. Guerin, R.N. Price   +6 more
doaj   +1 more source

Simple field assays to check quality of current artemisinin-based antimalarial combination formulations. [PDF]

, 2009
INTRODUCTION: Malaria continues to be one of the major public health problems in Africa, Asia and Latin America. Artemisinin derivatives (ARTs; artesunate, artemether, and dihydroartemisinin) derived from the herb, Artemisia annua, are the most effective
Ioset, Jean-Robert, Kaur, Harparkash, Harparkash Kaur, Kaur Harparkash, Jean-Robert Ioset, Ioset Jean-Robert   +5 more
core   +2 more sources

Overexpression of Plasmodium falciparum M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development

Pathogens, 2021
Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavage ...
Carolina C. Hoff, Mauro F. Azevedo, Adriana B. Thurler, Sarah El Chamy Maluf, Pollyana M. S. Melo, Maday Alonso del Rivero, Jorge González-Bacerio, Adriana K. Carmona, Alexandre Budu, Marcos L. Gazarini   +9 more
doaj   +1 more source

Antimalarial and toxicological assessment of the tablet (AS201-01) ethyl acetate fraction of Andrographis paniculata Nees in animal models [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Andrographis paniculata has been used as a traditional medicine to treat malaria. The ethyl acetate fraction of A. paniculata containing diterpene lactone compounds was developed into a tablet dosage form, AS201-01.
Aty Widyawaruyanti, Hilkatul Ilmi, Lidya Tumewu, Dwi Ayu Fitrianingtyas, Yesinta Kurniawati, Alfin Laila Najiha, Hanifah Khairun Nisa, Che Puteh Osman, Nor Hadiani Ismail, Achmad Fuad Hafid   +9 more
doaj   +1 more source

The rationale and plan for creating a World Antimalarial Resistance Network (WARN) [PDF]

, 2007
Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout of effective new drug ...
Barnes, Karen I., Karen I Barnes, Christopher V Plowe, Carol Sibley, Barnes, Karen I, Plowe, Christopher V., Sibley, Carol Hopkins, Plowe, Christopher V, Plowe Christopher V, Sibley Carol, Barnes Karen I   +10 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Synthesis and Structure-Activity Relationships of New 2-Phenoxybenzamides with Antiplasmodial Activity

Pharmaceuticals, 2021
The 2-phenoxybenzamide 1 from the Medicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach.
Theresa Hermann, Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis   +8 more
doaj   +1 more source