Results 31 to 40 of about 51,644 (231)

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia

International Journal of Health Geographics, 2016
Background Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here
Eric P. M. Grist, Jennifer A. Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim J. C. Anderson, Elizabeth A. Ashley, Nicholas P. J. Day, Mehul Dhorda, Arjen M. Dondorp, M. Abul Faiz, Peter W. Gething, Tran T. Hien, Tin M. Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J. Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, Francois Nosten, Paul N. Newton, Ric N. Price, Sasithon Pukrittayakamee, Shannon Takala-Harrison, Frank Smithuis, Nhien T. Nguyen, Kyaw M. Tun, Nicholas J. White, Benoit Witkowski, Charles J. Woodrow, Rick M. Fairhurst, Carol Hopkins Sibley, Philippe J. Guerin   +33 more
doaj   +1 more source

Structural Optimization of BIPPO Analogs as Potent Antimalarials

Molecules, 2023
Malaria continues to pose a significant health threat, causing thousands of deaths each year. The limited availability of vaccines and medications, combined with the emergence of drug resistance, further complicates the fight against this disease.
Yang Zheng, An Matheeussen, Louis Maes, Guy Caljon, Geert Jan Sterk, Rob Leurs   +5 more
doaj   +1 more source

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review

BMC Medicine, 2018
Background Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation.
Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin, Nicholas J. White   +3 more
doaj   +1 more source

Novel Leu-Val Based Dipeptide as Antimicrobial and Antimalarial Agents: Synthesis and Molecular Docking

Frontiers in Chemistry, 2020
The increase of antimicrobial resistance (AMR) and antimalarial resistance are complex and severe health issues today, as many microbial strains have become resistant to market drugs.
James A. Ezugwu, James A. Ezugwu, Uchechukwu C. Okoro, Mercy A. Ezeokonkwo, China R. Bhimapaka, Sunday N. Okafor, David I. Ugwu, Ogechi C. Ekoh, Solomon I. Attah   +8 more
doaj   +1 more source

New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria [PDF]

Journal of the Serbian Chemical Society, 2013
Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs ...
Tot Mikloš, Opsenica Dejan M., Mitrić Milena, Burnett James C., Gomba Laura, Bavari Sina, Šolaja Bogdan A.   +6 more
doaj   +1 more source

The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca²⁺ Homeostasis by Targeting a Unique Ion Channel

Pharmaceutics, 2022
Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international collaborative team focuses on developing multistage antimalarials that exhibit novel mechanisms of action.
Yash Gupta, Neha Sharma, Snigdha Singh, Jesus G. Romero, Vinoth Rajendran, Reagan M. Mogire, Mohammad Kashif, Jordan Beach, Walter Jeske, Poonam, Bernhards R. Ogutu, Stefan M. Kanzok, Hoseah M. Akala, Jennifer Legac, Philip J. Rosenthal, David J. Rademacher, Ravi Durvasula, Agam P. Singh, Brijesh Rathi, Prakasha Kempaiah   +19 more
doaj   +1 more source

Bioassay-Guided Fractionation with Antimalarial and Antimicrobial Activities of Paeonia officinalis

Molecules, 2022
Bioassay-guided fractionation technique of roots of Paeonia officinalis led to isolation and structure elucidation of seven known compounds, including four monoterpene glycosides: lactiflorin (1), paeoniflorin (4), galloyl paeoniflorin (5), and (Z)-(1S ...
Mamdouh Nabil Samy, Basma Khalaf Mahmoud, Nourhan Hisham Shady, Usama Ramadan Abdelmohsen, Samir Anis Ross   +4 more
doaj   +1 more source

Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Malaria Journal, 2019
Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment in low transmission areas. However, uptake of this recommendation has
Jaishree Raman, Elizabeth Allen, Lesley Workman, Aaron Mabuza, Hendrik Swanepoel, Gillian Malatje, John Frean, Lubbe Wiesner, Karen I. Barnes   +8 more
doaj   +1 more source

The differences of parasitemia in Plasmodium berghei infected mice treated with extract of mango parasite leaves with Artemisinin combination

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2023
Malaria is a disease transmitted through the bite of a female Anopheles mosquito caused by the Plasmodium parasite. Plasmodium has been reported to become resistant to artemisinin.
Muhammad Zulkifly Tasman, Heny Arwati, Nurina Hasanatuludhhiyah, Puspa Wardhani   +3 more
doaj   +1 more source

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review

Malaria Journal, 2017
Background Considering the uncertainty of safety of anti-malarial drugs in pregnancy, efficacy studies are one of the few sources of clinical safety data.
Makoto Saito, Mary Ellen Gilder, François Nosten, Philippe J. Guérin, Rose McGready   +4 more
doaj   +1 more source