Results 31 to 40 of about 113,882 (274)

Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809

Molecules, 2022
Dibutyl phthalate (DBP) produced by Streptomyces sp. H11809 exerted inhibitory activity against human GSK-3β (Hs GSK-3β) and Plasmodiumfalciparum 3D7 (Pf 3D7) malaria parasites.
Fauze Mahmud, Ngit Shin Lai, Siew Eng How, Jualang Azlan Gansau, Khairul Mohd Fadzli Mustaffa, Chiuan Herng Leow, Hasnah Osman, Hasidah Mohd Sidek, Noor Embi, Ping-Chin Lee   +9 more
doaj   +1 more source

The Vivax Surveyor: Online mapping database for Plasmodium vivax clinical trials

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Introduction: Recurrent P. vivax infections are associated with significant morbidity and mortality. Although radical cure can reduce recurrent infection, it is confounded by antimalarial resistance and the lack of safe and effective hypnozoitocidal ...
R.J. Commons, K. Thriemer, G. Humphreys, I. Suay, C.H. Sibley, P.J. Guerin, R.N. Price   +6 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, EarlyView.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa

Molecules, 2023
Malaria remains a life-threatening health problem and is responsible for the high rates of mortality and morbidity in the tropical and subtropical regions of the world.
Sampada S. Sawant, Satish Y. Gabhe, Kamalinder K. Singh   +2 more
doaj   +1 more source

Investigating the relationship between Pfkelch13 mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria: a protocol for a systematic review and individual patient data meta-analysis

BMJ Open
Introduction Artemisinin-based combination therapies (ACTs) remain the WHO-recommended treatment for uncomplicated Plasmodium falciparum malaria. However, the emergence and spread of artemisinin resistance (ART-R) threatens ACT efficacy.
Prabin Dahal, Philippe Guerin, Farhad Shokraneh, James A Watson, Karen I Barnes, Aboubakar Soma, Stephanie van Wyk, Chistevy Vouvoungui, Dhol S Ayuen   +8 more
doaj   +1 more source

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia

International Journal of Health Geographics, 2016
Background Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here
Eric P. M. Grist, Jennifer A. Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim J. C. Anderson, Elizabeth A. Ashley, Nicholas P. J. Day, Mehul Dhorda, Arjen M. Dondorp, M. Abul Faiz, Peter W. Gething, Tran T. Hien, Tin M. Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J. Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, Francois Nosten, Paul N. Newton, Ric N. Price, Sasithon Pukrittayakamee, Shannon Takala-Harrison, Frank Smithuis, Nhien T. Nguyen, Kyaw M. Tun, Nicholas J. White, Benoit Witkowski, Charles J. Woodrow, Rick M. Fairhurst, Carol Hopkins Sibley, Philippe J. Guerin   +33 more
doaj   +1 more source

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review

BMC Medicine, 2018
Background Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation.
Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin, Nicholas J. White   +3 more
doaj   +1 more source

Phytochemical screening, antimalarial activities, and genetic relationship of 16 indigenous Thai Asteraceae medicinal plants: A combinatorial approach using phylogeny and ethnobotanical bioprospecting in antimalarial drug discovery

Journal of Advanced Pharmaceutical Technology & Research, 2021
Emergence of artemisinin resistance leads the people to discover the new candidate for antimalarial drug. Combinatorial phylogeny and ethnobotanical approach may be useful to minimize the expenditure and time in laboratory testing.
Desy Liana, Kanchana Rungsihirunrat
doaj   +1 more source

Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data [PDF]

, 2012
People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymorphic locus.
Amanda Ross, Cristian Koepfli, Ingrid Felger, Ivo Mueller, João Pinto, Peter Siba, Sonja Schoepflin, Thomas Smith, Xiaohong Li   +8 more
core   +3 more sources