Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis [PDF]
Malaria Journal, 2019 Background Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of ...
The WorldWide Antimalarial Resistance Network Methodology Study Group
doaj +4 more sources
BMC Medicine, 2022 Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P.
The WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group
doaj +2 more sources
In vitro antimalarial activity of essential oils of Deverra scoparia Coss. & Dur | JBES [PDF]
, 2022 Supplemental Materials: https://osf.io/yzev9/The essential oils of the plant Deverra scoparia Coss. & Dur. (Apiaceae) used in traditional medicine in Algeria were subjected to testing the antimalarial activity.
Sanon, Soulaymene +2 more
core +1 more source
The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]
, 2003 Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT) +1 more
core +2 more sources
Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]
, 2013 Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA +3 more
core +1 more source
Screening of Traditionally Used Plants for in Vivo Antimalarial Activity in Mice. [PDF]
, 2009 Aqueous ethanol (80%) extracts of six plants used traditionally for treatment of malaria, Vepris glomerata (F.Hoffm.) Engl (Rutaceae), Maranthus floribunda (Bak.) F.White (Chrysobalanaceae), Strophanthus eminii Asch.
Mbwambo, Zakaria H. +27 more
core +1 more source
The perils of PCR: can we accurately 'correct' antimalarial trials? [PDF]
, 2010 During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.
Sutherland, Colin J +6 more
core +1 more source
Severe <i>Plasmodium vivax</i> Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report. [PDF]
Clin Case RepABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Nafian T +5 more
europepmc +2 more sources
Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. [PDF]
, 2008 BACKGROUND: New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria.
Njama-Meya Denise +44 more
core +1 more source
Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières. [PDF]
, 2008 Jean-Paul Guthmann and colleagues describe the output of MSF's work in antimalarial efficacy assessment during the last ...
Comte, Eric +44 more
core +1 more source