Results 11 to 20 of about 113,882 (274)

Molecular detection of human Plasmodium species using a multiplex real time PCR

Scientific Reports, 2023
Molecular detection methods have revealed higher sensitivity and specificity than conventional microscopy or rapid diagnostic tests for malaria diagnosis.
Yassamine Lazrek, Célia Florimond, Béatrice Volney, Manon Discours, Emilie Mosnier, Sandrine Houzé, Stéphane Pelleau, Lise Musset   +7 more
doaj   +1 more source

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

BMC Medical Research Methodology, 2019
Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence.
Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson   +5 more
doaj   +1 more source

Predictors of Antibiotics Co-prescription with Antimalarials for Patients Presenting with Fever in Rural Tanzania. [PDF]

, 2013
Successful implementation of malaria treatment policy depends on the prescription practices for patients with malaria. This paper describes prescription patterns and assesses factors associated with co-prescription of antibiotics and artemether ...
A Mannan, Alexander N Dodoo, ANO Dodoo, B Ahsan, BK Abuaku, BP Mmbando, Brown Kigahe, C Watsierah, CIR Chandler, CIR Chandler, D Zurovac, Dan Kajungu, EME Van Bijnen, F Font, F Font, H Reyburn, H Reyburn, H Riaz, I Masanja, I Tamuno, Ifakara, IM Masanja, Irene Masanja, JR Torvi, JU Okebe, K Bashrahil, K Shamshy, KA Oshikoya, LEG Mboera, Majige Selemani, Mbaraka Amuri, MI Masanja, ML McMorrow, ML Mcmorrow, Mustafa Njozi, Mwageni, N Nshakira, National Malaria Control Programe (NMCP) [Tanania], National Malaria Control Programme (NMCP) [Tanzania], P Winskill, Rashid Khatib, Salim Abdula, TO Ogungbamigbe, VA Badar   +43 more
core   +2 more sources

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Malaria Journal, 2017
The Kaplan–Meier (K–M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one
Prabin Dahal, Julie A. Simpson, Grant Dorsey, Philippe J. Guérin, Ric N. Price, Kasia Stepniewska   +5 more
doaj   +1 more source

On the survival of 48 h Plasmodium vivax Aotus monkey-derived ex vivo cultures: the role of leucocytes filtration and chemically defined lipid concentrate media supplementation

Malaria Journal, 2020
Background Filtration of leukocytes (WBCs) is a standard practice of malaria ex vivo cultures. To date, few studies have considered the effect of filtration or the lack thereof on the survival of Plasmodium vivax ex vivo cultures through one cycle of ...
Nicanor Obaldía, Marlon Nuñez
doaj   +1 more source

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo, Flohe, Moreno, Viode, Henderson, Walsh, Krauth-Seigel, Muller, Nogoceke, Tetaud, Wilkinson, Wilkinson, Tetaud, Wilkinson, Boveris, Fairlamb, Mehlotra, Carnieri, Kendall, Kelly, Gibson, Martinez-Calvillo, Kelly, Kelly, Kelly, Cannata, Rutter, Easterby, Gommel, Steinert, Sommer, Opperdoes, Opperdoes, Michels, Parsons, Blattner, Bjornstedt, Sztajer, Horiguchi, Holgren, Fabianek, Shih, Shih, van den Bosch, Subramani, Keller, Singh, Singh, Boveris, Duffieux, Goodman, Knoops, Yamashita, Verdoucq, Seo, Lopez, Krieger   +56 more
core   +3 more sources

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Infectious Diseases of Poverty, 2019
Background The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs).
Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Wellington Oyibo, Francis Useh, Temitope Aderoyeje, Titilope M. Dokunmu, Omobolaji T. Alebiosu, Sikiru Amoo, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Chukwuebuka Okafor, Odafe Akpoborie, Bayo Fatunmbi, Elsie O. Adewoye, Nnenna M. Ezeigwe, Ayoade Oduola   +35 more
doaj   +1 more source

Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan. [PDF]

, 2004
To provide advice on the rational use of antimalarial drugs, Médecins Sans Frontières conducted a randomized, an open label efficacy study in Kajo Keji, an area of high transmission of malaria in southern Sudan.
Epicentre, Krishna S, Kshirsagar NA, National Malaria Administration/Unicef, Ochong EO, Omari AA, Seidlein L, UN/OCHA, Vugt M, WHO, WHO, WHO, WHO, WHO/Roll Back Malaria   +13 more
core   +2 more sources

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

BMC Infectious Diseases, 2017
Background Artemisinin-based combination therapies (ACTs) have remained efficacious treatments of acute falciparum malaria in many endemic areas but there is little evaluation of factors contributing to the anaemia of acute falciparum malaria following ...
Akintunde Sowunmi, Bayo Fatunmbi, Kazeem Akano, Olubunmi A. Wewe, Chimere Agomo, Finomo Finomo, Joy Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, Godwin Ntadom, Olugbenga Mokuolu, George Emechebe, Nnenna Ezeigwe, Adejumoke I. Ayede, Elsie O. Adewoye, Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, Stephen Oguche, Wellington A. Oyibo, Francis Useh   +21 more
doaj   +1 more source