Results 11 to 20 of about 51,644 (231)

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Malaria Journal, 2017
The Kaplan–Meier (K–M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one
Prabin Dahal, Julie A. Simpson, Grant Dorsey, Philippe J. Guérin, Ric N. Price, Kasia Stepniewska   +5 more
doaj   +1 more source

On the survival of 48 h Plasmodium vivax Aotus monkey-derived ex vivo cultures: the role of leucocytes filtration and chemically defined lipid concentrate media supplementation

Malaria Journal, 2020
Background Filtration of leukocytes (WBCs) is a standard practice of malaria ex vivo cultures. To date, few studies have considered the effect of filtration or the lack thereof on the survival of Plasmodium vivax ex vivo cultures through one cycle of ...
Nicanor Obaldía, Marlon Nuñez
doaj   +1 more source

Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action

Frontiers in Cellular and Infection Microbiology, 2023
Over the last two decades, global malaria cases caused by Plasmodium falciparum have declined due to the implementation of effective treatments and the use of insecticides.
Annie-Peiyuan Luo, Carlo Giannangelo, Ghizal Siddiqui, Darren J. Creek   +3 more
doaj   +1 more source

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Infectious Diseases of Poverty, 2019
Background The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs).
Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Wellington Oyibo, Francis Useh, Temitope Aderoyeje, Titilope M. Dokunmu, Omobolaji T. Alebiosu, Sikiru Amoo, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Chukwuebuka Okafor, Odafe Akpoborie, Bayo Fatunmbi, Elsie O. Adewoye, Nnenna M. Ezeigwe, Ayoade Oduola   +35 more
doaj   +1 more source

Phytochemistry and Bioactivity of Nepeta racemosa Lam. [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: The genus Nepeta is used in traditional medicine for the antiseptic and astringent properties in cutaneous eruptions and snake bites.
Fariba Heshmati Afshar, Abbas Delazar, Yahya Rahimpour, Niloufar Moharrer Navaei, Solmaz Asnaashari, Parina Asgharian*   +5 more
doaj   +1 more source

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

BMC Infectious Diseases, 2017
Background Artemisinin-based combination therapies (ACTs) have remained efficacious treatments of acute falciparum malaria in many endemic areas but there is little evaluation of factors contributing to the anaemia of acute falciparum malaria following ...
Akintunde Sowunmi, Bayo Fatunmbi, Kazeem Akano, Olubunmi A. Wewe, Chimere Agomo, Finomo Finomo, Joy Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, Godwin Ntadom, Olugbenga Mokuolu, George Emechebe, Nnenna Ezeigwe, Adejumoke I. Ayede, Elsie O. Adewoye, Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, Stephen Oguche, Wellington A. Oyibo, Francis Useh   +21 more
doaj   +1 more source

8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity

Molecules, 2021
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution ...
Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis   +6 more
doaj   +1 more source

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Infectious Diseases of Poverty, 2018
Background In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin derivatives.
Kazeem Akano, Godwin Ntadom, Chimere Agomo, Christian T. Happi, Onikepe A. Folarin, Grace O. Gbotosho, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Sikiru Amoo, Nnenna Ezeigwe, Stephen Oguche, Bayo Fatunmbi, Akintunde Sowunmi   +19 more
doaj   +1 more source

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

BMC Medicine, 2022
Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P.
The WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group
doaj   +1 more source

Malaria prevention practices and malaria prevalence among children living in a rural community in Southwest Nigeria

Journal of Infection in Developing Countries, 2022
Introduction: Living conditions in most rural African communities favour malaria transmission and threaten global eradication. Prevention strategies and interventions such as the use of bed nets have reduced the prevalence of malaria.
Odunayo Adebukola Temitope Fatunla, Oladele Simeon Olatunya, Ezra Olatunde Ogundare, Tolulope Oladapo Fatunla, Adefunke Olarinre Babatola, Adewuyi Temidayo Adeniyi, Oyeku Akibu Oyelami   +6 more
doaj   +1 more source