Results 1 to 10 of about 113,882 (274)

Marine Antimalarials [PDF]

Marine Drugs, 2009
Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with
FATTORUSSO, ERNESTO, TAGLIALATELA SCAFATI, ORAZIO   +1 more
openaire   +4 more sources

Molecular surveillance for operationally relevant genetic polymorphisms in Plasmodium falciparum in Southern Chad, 2016–2017

Malaria Journal, 2022
Background Resistance to anti-malarials is a serious threat to the efforts to control and eliminate malaria. Surveillance based on simple field protocols with centralized testing to detect molecular markers associated with anti-malarial drug resistance ...
Sukanta Das, Clément Kérah-Hinzoumbé, Moundiné Kebféné, Suttipat Srisutham, Tog-Yeum Nagorngar, Naowarat Saralamba, Ranitha Vongpromek, Teeradet Khomvarn, Carol H. Sibley, Philippe J. Guérin, Mallika Imwong, Mehul Dhorda   +11 more
doaj   +1 more source

Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Malaria Journal, 2022
Background The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at ...
The WorldWide Antimalarial Resistance Network Methodology Study Group
doaj   +1 more source

Making data map-worthy—enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study

Malaria Journal, 2022
Background Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected.
Frank M. Kagoro, Elizabeth Allen, Aaron Mabuza, Lesley Workman, Ray Magagula, Gerdalize Kok, Craig Davies, Gillian Malatje, Philippe J. Guérin, Mehul Dhorda, Richard J. Maude, Jaishree Raman, Karen I. Barnes   +12 more
doaj   +1 more source

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

BMC Medical Research Methodology, 2019
Background Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primary endpoint of interest).
Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson, Kasia Stepniewska   +4 more
doaj   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor

Malaria Journal, 2019
Background Prior to this project, only a handful of online visualizations existed for exploring the published literature on molecular markers of antimalarial drug resistance, and none specifically for the markers associated with Plasmodium falciparum ...
Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman, Georgina S. Humphreys   +6 more
doaj   +1 more source

Comparative analysis of two methods for measuring sales volumes during malaria medicine outlet surveys. [PDF]

, 2013
BACKGROUND: There is increased interest in using commercial providers for improving access to quality malaria treatment. Understanding their current role is an essential first step, notably in terms of the volume of diagnostics and anti-malarials they ...
Goodman, Catherine, Hanson, Kara, Kleinschmidt, Immo, O'Connell, Kate, Palafox, Benjamin, Patouillard, Edith, Pok, Sochea, Tougher, Sarah   +7 more
core   +2 more sources

Antiplasmodial activity of p-substituted benzyl thiazinoquinone derivatives and their potential against parasitic infections [PDF]

, 2020
Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control ...
Basilico, Nicoletta, Casertano, Marcello, Fattorusso, Caterina, Imperatore, Concetta, Menna, Marialuisa, Parapini, Silvia, Persico, Marco   +6 more
core   +2 more sources

Complex interactions between malaria and malnutrition: a systematic literature review

BMC Medicine, 2018
Background Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of thousands of deaths in children in resource-poor ...
D Das, R F Grais, E A Okiro, K Stepniewska, R Mansoor, S van der Kam, D J Terlouw, J Tarning, K I Barnes, P J Guerin   +9 more
doaj   +1 more source