Results 21 to 30 of about 80,047 (217)

Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action

Frontiers in Cellular and Infection Microbiology, 2023
Over the last two decades, global malaria cases caused by Plasmodium falciparum have declined due to the implementation of effective treatments and the use of insecticides.
Annie-Peiyuan Luo, Carlo Giannangelo, Ghizal Siddiqui, Darren J. Creek   +3 more
doaj   +1 more source

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

BMC Infectious Diseases, 2017
Background Artemisinin-based combination therapies (ACTs) have remained efficacious treatments of acute falciparum malaria in many endemic areas but there is little evaluation of factors contributing to the anaemia of acute falciparum malaria following ...
Akintunde Sowunmi, Bayo Fatunmbi, Kazeem Akano, Olubunmi A. Wewe, Chimere Agomo, Finomo Finomo, Joy Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, Godwin Ntadom, Olugbenga Mokuolu, George Emechebe, Nnenna Ezeigwe, Adejumoke I. Ayede, Elsie O. Adewoye, Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, Stephen Oguche, Wellington A. Oyibo, Francis Useh   +21 more
doaj   +1 more source

Phytochemistry and Bioactivity of Nepeta racemosa Lam. [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: The genus Nepeta is used in traditional medicine for the antiseptic and astringent properties in cutaneous eruptions and snake bites.
Fariba Heshmati Afshar, Abbas Delazar, Yahya Rahimpour, Niloufar Moharrer Navaei, Solmaz Asnaashari, Parina Asgharian*   +5 more
doaj   +1 more source

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Infectious Diseases of Poverty, 2019
Background The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs).
Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Wellington Oyibo, Francis Useh, Temitope Aderoyeje, Titilope M. Dokunmu, Omobolaji T. Alebiosu, Sikiru Amoo, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Chukwuebuka Okafor, Odafe Akpoborie, Bayo Fatunmbi, Elsie O. Adewoye, Nnenna M. Ezeigwe, Ayoade Oduola   +35 more
doaj   +1 more source

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Infectious Diseases of Poverty, 2018
Background In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin derivatives.
Kazeem Akano, Godwin Ntadom, Chimere Agomo, Christian T. Happi, Onikepe A. Folarin, Grace O. Gbotosho, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Sikiru Amoo, Nnenna Ezeigwe, Stephen Oguche, Bayo Fatunmbi, Akintunde Sowunmi   +19 more
doaj   +1 more source

8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity

Molecules, 2021
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution ...
Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis   +6 more
doaj   +1 more source

A novel antimalarial lead compound: in vitro properties and mode of action studies [PDF]

, 2011
Malaria remains a major public health problem and the increasing number of resistant strains underscores the need for new drugs with new modes of action (MOAs).
Brunner, Ralf Oskar
core   +1 more source

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis

BMJ Open, 2019
IntroductionAntimalarial posology based on weight bands leaves patients at the margins vulnerable to receiving either lower or higher weight-adjusted (mg/kg) dosages. This article aims to describe the protocol for systematic review and individual patient
Prabin Dahal, Philippe Guerin, Elizabeth A Ashley   +2 more
doaj   +1 more source

World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. [PDF]

, 2007
The proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods undermines
Laufer, M K, Sibley, C H, Sibley, CH, Stepniewska, Barnes, K I, Guerin, P J, Philippe J Guerin, Ringwald, P, Grant Dorsey, Olliaro, P., Naidoo, I, J Kevin Baird, Stepniewska, K., d'Alessandro, U, Olliaro, P, Miriam K Laufer, Ashley, EA, Guerin, Philippe J, d\u27Alessandro, Umberto, Guerin, Philippe J., Laufer, M. K., François Nosten, D'Alessandro, U., Plowe, CV, Price, R N, Pascal Ringwald, Ringwald, Pascal, Barnes, Karen, Dorsey, G, d'Alessandro, Umberto, Barnes, K. I., Baird, J. Kevin, Inbarani Naidoo, Nicholas J White, Laufer, MK, Ashley, Elizabeth A, Stepniewska, K, Guerin, Philippe, Sibley, C. H., Naidoo, I., Christopher V Plowe, Ashley, E. A., Baird, John, Baird, J K, White, Nicholas, Nosten, François, Sibley, Carol H, Ashley, Elizabeth A., White, Nicholas J., Nosten, F., Barnes, KI, White, N. J., Price, Ric, Dorsey, Grant, Plowe, C V, Ashley, E A, Plowe, Christopher, Carol H Sibley, Baird, K., Barnes, Karen I., Baird, JK, White, Nicholas J, Laufer, Miriam K, Umberto d'Alessandro, Elizabeth A Ashley, Plowe, Christopher V., Nosten, F, White, N J, Guerin, PJ, Karen I Barnes, Guerin, P. J., Baird, J Kevin, Piero Olliaro, Plowe, C. V., Barnes, Karen I, Price, R. N., Sibley, Carol H., Dorsey, G., Price, Ric N., Plowe, Christopher V, Ringwald, P., Sibley, Carol, Laufer, Miriam K., Price, RN, Naidoo, Inbarani, Stepniewska, Kasia, Ashley, Elizabeth, Price, Ric N, Ric N Price, Kasia Stepniewska, White, NJ, Laufer, Miriam, Olliaro, Piero   +92 more
core   +1 more source

Malaria prevention practices and malaria prevalence among children living in a rural community in Southwest Nigeria

Journal of Infection in Developing Countries, 2022
Introduction: Living conditions in most rural African communities favour malaria transmission and threaten global eradication. Prevention strategies and interventions such as the use of bed nets have reduced the prevalence of malaria.
Odunayo Adebukola Temitope Fatunla, Oladele Simeon Olatunya, Ezra Olatunde Ogundare, Tolulope Oladapo Fatunla, Adefunke Olarinre Babatola, Adewuyi Temidayo Adeniyi, Oyeku Akibu Oyelami   +6 more
doaj   +1 more source