Results 21 to 30 of about 113,882 (274)

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Infectious Diseases of Poverty, 2018
Background In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin derivatives.
Kazeem Akano, Godwin Ntadom, Chimere Agomo, Christian T. Happi, Onikepe A. Folarin, Grace O. Gbotosho, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Sikiru Amoo, Nnenna Ezeigwe, Stephen Oguche, Bayo Fatunmbi, Akintunde Sowunmi   +19 more
doaj   +1 more source

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

BMC Medicine, 2022
Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P.
The WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group
doaj   +1 more source

Analysis of Quantitative Structure-Activity Relationship (QSAR) Of 1,8-Napthalymide-4-Aminoquinoline Derivatives as Antimalarial Compounds

Walisongo Journal of Chemistry, 2022
QSAR analysis from derivative compounds of 1,8-naphthalimide-4-aminoquinoline has been carried out with the aim of knowing the quantitative relationship between structure and activity based on the log IC50 value.
Ika Nur Fitriani, Muhammad Sholahudin, Adi Tiara Zikri   +2 more
doaj   +1 more source

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis

BMJ Open, 2019
IntroductionAntimalarial posology based on weight bands leaves patients at the margins vulnerable to receiving either lower or higher weight-adjusted (mg/kg) dosages. This article aims to describe the protocol for systematic review and individual patient
Prabin Dahal, Philippe Guerin, Elizabeth A Ashley   +2 more
doaj   +1 more source

Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

Frontiers in Pharmacology, 2023
Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers ...
Tareq Abu-Izneid, Muhammad Abbas, David G. Watson, Yasar Shah, Sayyed I. Shah, Fazli Khuda   +5 more
doaj   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
Background In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended ...
Rebecca F. Grais, Ibrahim M. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, Celine Langendorf, Alfred Amambua-Ngwa, Umberto D’Alessandro, Philippe J. Guérin, Thierry Fandeur, Carol H. Sibley   +10 more
doaj   +1 more source

In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum

WMJ (Warmadewa Medical Journal), 2022
Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose ...
Prawesty Diah Utami, Zuhro
doaj   +1 more source

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources