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Artesunate repurposing for cytomegalovirus management: a systematic review of efficacy, mechanisms, and perspectives [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundCytomegalovirus (CMV) is a prevalent opportunistic pathogen associated with significant morbidity and mortality in immunocompromised individuals, particularly transplant recipients and neonates. Current antiviral therapies are often constrained
Haohao Zhang, Haohao Zhang, Fanchao Zhou, Jianping Song, Changsheng Deng, Xiao He, Suiqin Ni   +6 more
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Network pharmacology-based predictions of active components and pharmacological mechanisms of Artemisia annua L. for the treatment of the novel Corona virus disease 2019 (COVID-19)

BMC Complementary Medicine and Therapies, 2022
Background Novel Corona Virus Disease 2019 (COVID-19) is closely associated with cytokines storms. The Chinese medicinal herb Artemisia annua L. (A. annua) has been traditionally used to control many inflammatory diseases, such as malaria and rheumatoid ...
Yexiao Tang, Xiaobo Li, Yueming Yuan, Hongying Zhang, Yuanyuan Zou, Zhiyong Xu, Qin Xu, Jianping Song, Changsheng Deng, Qi Wang   +9 more
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The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis

Frontiers in Pharmacology, 2022
The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the host ...
Yuanyuan Zou, Nadia Julie, Shiyuan Guo, Yexiao Tang, Hongying Zhang, Zhiyong Xu, Wanting Wu, Yueming Yuan, Zhibin Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Changsheng Deng, Jianping Song, Qi Wang, Qi Wang   +16 more
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Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats

BMC Complementary Medicine and Therapies, 2022
Background: The WHO recommends artemisinin-based combination regimens for uncomplicated Plasmodium falciparum malaria. One such combination is artemisinin-piperaquine tablets (ATQ).
Xiaobo Li, Yueming Yuan, Yingyi Chen, Li Ru, Zheng Yuan, Zhiyong Xu, Qin Xu, Jianping Song, Guoming Li, Changsheng Deng   +9 more
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Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα

Molecules, 2022
Garcinia biflavonoid 1 (GB1) is one of the active chemical components of Garcinia kola and is reported to be capable of reducing the intracellular lipid deposition, which is the most significant characteristic of non-alcoholic fatty liver disease ...
Hai-Xin Chen, Fan Yang, Xin-Qian He, Ting Li, Yong-Zhi Sun, Jian-Ping Song, Xin-An Huang, Wen-Feng Guo   +7 more
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Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

Journal of Nanobiotechnology, 2023
Background Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence of drug resistance, novel strategies to control malaria are urgently needed.
Zhouqing He, Chuyi Yu, Ziyi Pan, Xiaobo Li, Xiangxiang Zhang, Qijing Huang, Xingcheng Liao, Jiaoting Hu, Feng Zeng, Li Ru, Wanlin Yu, Qin Xu, Jianping Song, Jianming Liang   +13 more
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Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway

Frontiers in Pharmacology, 2022
Vanillic acid, a phenolic compound mainly obtained from the foot of Picrorhiza scrophulariiflora Pennell, has been demonstrated to possess a cardiovascular-protective effect in previous studies.
Manxue Mei, Haoxiang Sun, Jiayu Xu, Yimeng Li, Guiling Chen, Qihua Yu, Changsheng Deng, Wei Zhu, Jianping Song   +8 more
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Efficacy and Safety of Artemisinin-Piperaquine for the Treatment of Uncomplicated Malaria: A Systematic Review

Frontiers in Pharmacology, 2020
ObjectiveThe World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria to improve the therapeutic efficacy and limit the choice of drug-resistant parasites.
Qi Wang, Yuanyuan Zou, Ziyi Pan, Hongying Zhang, Changsheng Deng, Yueming Yuan, Yueming Yuan, Jiawen Guo, Jiawen Guo, Yexiao Tang, Nadia Julie, Wanting Wu, Guoming Li, Mingqiang Li, Ruixiang Tan, Xinan Huang, Wenfeng Guo, Changqing Li, Qin Xu, Jianping Song   +19 more
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Safety and Efficacy of Adjunctive Therapy With Artesunate in the Treatment of Severe Malaria: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple
Yuanyuan Zou, Fei Tuo, Zhiqi Zhang, Jiawen Guo, Yueming Yuan, Yueming Yuan, Hongying Zhang, Zhiyong Xu, Ziyi Pan, Yexiao Tang, Changsheng Deng, Nadia Julie, Wanting Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Jianping Song, Qi Wang   +18 more
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Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids

Molecules, 2021
Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms, bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally elucidated, and they can be classified into two groups of C-C and C-linear ...
Xinqian He, Fan Yang, Xin’an Huang
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