Results 1 to 10 of about 37,512 (201)

Artemisinins [PDF]

Postgraduate Medical Journal, 2005
Abstract Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of clinically important resistance.
Woodrow, CJ, Haynes, RK, Krishna, S.
openaire   +5 more sources

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Acta Pharmaceutica Sinica B, 2021
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
Pamela Weathers, Tanja Dominko, David Dolivo   +2 more
exaly   +4 more sources

Artemisinin-resistant malaria

Clinical Microbiology Reviews
SUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
Nicholas White, Kesinee Chotivanich
exaly   +4 more sources

Artemisinin [PDF]

Chemie in unserer Zeit, 2014
AbstractArtemisinin ist der modernste Wirkstoff gegen Malaria, eine Infektionskrankheit, die den Menschen durch seine gesamte Entwicklungsgeschichte begleitete. Experimentelle Hinweise auf antike Malaria‐Epidemien gelangen durch Vervielfältigung von DNA‐Fragmenten des Erregers mit Hilfe der Polymerasekettenreaktion und dem Abgleich mit dem inzwischen ...
Paul May, Simon Cotton
  +7 more sources

Network pharmacology-based predictions of active components and pharmacological mechanisms of Artemisia annua L. for the treatment of the novel Corona virus disease 2019 (COVID-19)

BMC Complementary Medicine and Therapies, 2022
Background Novel Corona Virus Disease 2019 (COVID-19) is closely associated with cytokines storms. The Chinese medicinal herb Artemisia annua L. (A. annua) has been traditionally used to control many inflammatory diseases, such as malaria and rheumatoid ...
Yexiao Tang, Xiaobo Li, Yueming Yuan, Hongying Zhang, Yuanyuan Zou, Zhiyong Xu, Qin Xu, Jianping Song, Changsheng Deng, Qi Wang   +9 more
doaj   +1 more source

The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis

Frontiers in Pharmacology, 2022
The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the host ...
Yuanyuan Zou, Nadia Julie, Shiyuan Guo, Yexiao Tang, Hongying Zhang, Zhiyong Xu, Wanting Wu, Yueming Yuan, Zhibin Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Changsheng Deng, Jianping Song, Qi Wang, Qi Wang   +16 more
doaj   +1 more source

Artemisinin and Heme [PDF]

Antimicrobial Agents and Chemotherapy, 2003
A recent Letter to the Editor (R. K. Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and P. Olliaro, Letter, Antimicrob. Agents Chemother. 47:1175, 2003) presented cogent evidence that artemisinin and its derivatives do not inhibit hemozoin formation in vitro.
Haynes, Richard K., Monti, Diego, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia, Olliaro, Piero   +5 more
openaire   +5 more sources

Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα

Molecules, 2022
Garcinia biflavonoid 1 (GB1) is one of the active chemical components of Garcinia kola and is reported to be capable of reducing the intracellular lipid deposition, which is the most significant characteristic of non-alcoholic fatty liver disease ...
Hai-Xin Chen, Fan Yang, Xin-Qian He, Ting Li, Yong-Zhi Sun, Jian-Ping Song, Xin-An Huang, Wen-Feng Guo   +7 more
doaj   +1 more source

Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats

BMC Complementary Medicine and Therapies, 2022
Background: The WHO recommends artemisinin-based combination regimens for uncomplicated Plasmodium falciparum malaria. One such combination is artemisinin-piperaquine tablets (ATQ).
Xiaobo Li, Yueming Yuan, Yingyi Chen, Li Ru, Zheng Yuan, Zhiyong Xu, Qin Xu, Jianping Song, Guoming Li, Changsheng Deng   +9 more
doaj   +1 more source

Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

Journal of Nanobiotechnology, 2023
Background Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence of drug resistance, novel strategies to control malaria are urgently needed.
Zhouqing He, Chuyi Yu, Ziyi Pan, Xiaobo Li, Xiangxiang Zhang, Qijing Huang, Xingcheng Liao, Jiaoting Hu, Feng Zeng, Li Ru, Wanlin Yu, Qin Xu, Jianping Song, Jianming Liang   +13 more
doaj   +1 more source