Metabolites, 2022 Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced ...
Qixin Wang +19 more
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Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]
, 2006 OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G +21 more
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Putting the genie back in the bottle? Availability and presentation of oral artemisinin compounds at retail pharmacies in urban Dar-es-Salaam. [PDF]
, 2006 BACKGROUND\ud \ud Recently global health advocates have called for the introduction of artemisinin-containing antimalarial combination therapies to help curb the impact of drug-resistant malaria in Africa.
Catherine Goodman +7 more
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Network analysis of the effects of long non-coding RNAs in artemisinin treatment of atherosclerosis in APOE –/– mice [PDF]
, 2021 Introduction Atherosclerosis has become a worldwide medical burden. Our previous studies have shown that artemisinin (ART) had the capability to reduce atherosclerosis.
Zhao Qiao, Du Hongjiao, Li Xiaodong
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Simple field assays to check quality of current artemisinin-based antimalarial combination formulations. [PDF]
, 2009 INTRODUCTION: Malaria continues to be one of the major public health problems in Africa, Asia and Latin America. Artemisinin derivatives (ARTs; artesunate, artemether, and dihydroartemisinin) derived from the herb, Artemisia annua, are the most effective
Ioset, Jean-Robert +5 more
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Artemisinin-Based Smart Nanomedicines with Self-Supply of Ferrous Ion to Enhance Oxidative Stress for Specific and Efficient Cancer Treatment [PDF]
, 2019 Though abundant researches report that artemisinin could inhibit cancer cell growth via generating toxic reactive oxygen species (ROS), the therapeutic efficiency of artemisinin for cancer treatment is still limited owing to the insufficient ...
Bo-Yang Yu (1476181) +11 more
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Frontiers in Medicine, 2021 Ulcerative colitis (UC) is an inflammatory bowel disease. The intake of African Garcinia Kola nuts has been reported as a therapy for diarrhea and dysentery in the African population.
Yuanyuan Yu +15 more
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Chemical proteomics approach reveals the direct targets and the heme-dependent activation mechanism of artemisinin in Plasmodium falciparum using an activity-based artemisinin probe [PDF]
, 2016 Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation of artemisinin requires the cleavage of the endoperoxide bridge in the presence of iron sources. Once activated, artemisinins attack macromolecules through
Qingsong Lin, Jigang Wang
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Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. [PDF]
, 2005 BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are
Albert Kilian +59 more
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Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy
Journal of Nanobiotechnology, 2022 Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, and are becoming an ideal target for cancer ...
Liwei Gu +11 more
doaj +1 more source