Results 31 to 40 of about 28,538 (185)
Advanced Science, EarlyView.In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang +20 more
wiley +1 more source
Molecules, 2017 The complete chloroplast genome of Artemisia annua (Asteraceae), the primary source of artemisinin, was sequenced and analyzed. The A. annua cp genome is 150,995 bp, and harbors a pair of inverted repeat regions (IRa and IRb), of 24,850 bp each that ...
Xiaofeng Shen +9 more
doaj +1 more source
Frontiers in Medicine, 2021 Background: Mass drug administration with artemisinin-piperaquine (AP-MDA) is being considered for elimination of residual foci of malaria in Democratic Republic of São Tomé and Principe.Methods: Three monthly rounds of AP-MDA were implemented from July ...
Mingqiang Li +16 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang +9 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Dihydroartemisinin (DHA) and its’ derivatives have been employed as the most powerful first-line drugs for malarial treatment for several decades. The metabolism of DHA has not been studied clearly.
Yifan Zhao +17 more
doaj +1 more source
Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria
British Journal of Clinical Pharmacology, EarlyView.Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin +6 more
wiley +1 more source
Frontiers in PharmacologyBackgroundFu-zi decoction (FZD) has a long history of application for treating Rheumatoid arthritis (RA) as a classic formulation. However, its underlying mechanisms have not been fully elucidated.
Zhenzhen Pan +10 more
doaj +1 more source
Frontiers in Chemistry, 2020 Determination of serum cholesterol (Chol) is important for disease diagnosis, and has attracted great attention during the last few decades. Herein, a new magnetic nanoparticle-based ligand replacement strategy has been presented for chemical ...
Yalan Wu +8 more
doaj +1 more source
From Plant to Yeast—Advances in Biosynthesis of Artemisinin
Molecules, 2022 Malaria is a life-threatening disease. Artemisinin-based combination therapy (ACT) is the preferred choice for malaria treatment recommended by the World Health Organization.
Le Zhao +6 more
doaj +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source