Results 41 to 50 of about 37,512 (201)

China's foreign aid for global poverty alleviation: artemisinin-based combination therapies against malaria in Togo

Global Health Journal, 2021
From providing funds for the global fight against infectious diseases, to actively participating in global health security actions, to strengthening mutual cooperation in the field of health, and providing medical treatment, training and scholarships to ...
Qi Wang, Chuyi Yu, Hongying Zhang, Shaoqin Zheng, Jianping Song, Changsheng Deng   +5 more
doaj   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
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In vivo parasitological measures of artemisinin susceptibility [PDF]

, 2010
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the ...
Smithuis, F, Olliaro, P., Mayxay, Mayfong, Stepniewska, K., Newton, Paul N., de Vries, Peter J, Olliaro, P, Taylor, Walter R. J., Binh, Tran Quang, Ashley, E., de Vries, P. J., Newton, Paul N, Day, Nicholas PJ, D'Alessandro, U., Rowland, Mark, Mayxay, M, Guthmann, J. P., Ashley, E, Anstey, N., Dorsey, G, Barnes, K. I., Binh, TQ, Newton, PN, Guthmann, Jean-Paul, Lee, S. J., Stepniewska, K, Lee, Sue J, de Vries, Peter J., White, Nicholas, Lee, Sue J., Nosten, François, Anstey, N, White, Nicholas J., Guthmann, JP, Nosten, F., Lee, Sue, Barnes, KI, Taylor, W. R. J., White, N. J., Taylor, WR, Dorsey, Grant, Newton, P. N., de Vries, PJ, Osorio, L., Day, Nicholas P. J., Barnes, Karen I., White, Nicholas J, Rowland, M, Binh, T. Q., Taylor, Walter RJ, Day, NP, Smithuis, F., Nosten, F, Smithuis, Frank, Osorio, Lyda, Newton, Paul, Lee, SJ, Mayxay, M., Day, N. P. J., Barnes, Karen I, Dorsey, G., D'Alessandro, Umberto, Price, Ric N., Anstey, Nicholas, Day, Nicholas P J, Price, RN, Stepniewska, Kasia, Rowland, M., Day, Nicholas, Ashley, Elizabeth, Price, Ric N, Taylor, Walter R J, Osorio, L, D'Alessandro, U, White, NJ, Olliaro, Piero   +75 more
core   +2 more sources

Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania. [PDF]

, 2009
BACKGROUND: WHO estimates that only 3% of fever patients use recommended artemisinin-based combination therapies (ACTs), partly reflecting their high prices in the retail sector from where many patients seek treatment.
Catherine Goodman, Ward Lorrayne, Mwita, Alex, Oliver J Sabot, Odhiambo, Moses, Odhiambo Moses, Ipuge, Yahya, Sabot Oliver J., Cohen Justin M., Gordon Megumi, Bishop David, Justin M Cohen, Bishop, David, Moses Odhiambo, Megumi Gordon, Goodman Catherine, Ipuge Yahya, Gordon, Megumi, Cohen, Justin M, Sabot, Oliver J, Lorrayne Ward, Ward, Lorrayne, Mwita Alex, Goodman, Catherine, David Bishop, Yahya Ipuge, Alex Mwita   +26 more
core   +1 more source

Non-reductive Homolytic Scission of Endoperoxide Bond for Activation of Artemisinin: The Bi-radical Perspectives [PDF]

, 2021
Artemisinin is the most famous antimalarial drug against malaria caused by Plasmodium falciparum. Despite its tremendous success and popularity in malaria therapeutics, the molecular mechanism of artemisinin’s activity is still elusive.
Shikha, Sharma, Md. Ehesan, Ali
core   +1 more source

Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

Frontiers in Pharmacology, 2022
Background: Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated.Hypothesis/Purpose: We assumed
Qiaoli Shi, Qixin Wang, Jiayun Chen, Fei Xia, Chong Qiu, Min Li, Minghong Zhao, Minghong Zhao, Qian Zhang, Piao Luo, Tianming Lu, Ying Zhang, Liting Xu, Xueling He, Tianyu Zhong, Tianyu Zhong, Na Lin, Qiuyan Guo   +17 more
doaj   +1 more source

The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A, Mulligan Jo, Abdulla, Salim, Bloland, Peter, McHomvu, Naiman, Mills, Anne, Mills Anne, Mchomvu Naiman, Munkondya John S, Njau Joseph D, Abdulla Salim, Munkondya, John S, Bloland Peter, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, Kachur S Patrick, Mulligan, Jo   +17 more
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Acute and subacute oral toxicity assessment of Gancao Xiexin decoction in Sprague-Dawley rats

Frontiers in Pharmacology, 2023
Gancao Xiexin decoction (GCXXD), a well-known classic traditional Chinese medicine prescription, is used to treat various oral ulcers, Behcet disease, gastrointestinal ulcers, etc. However, there is very little information on its safety. This study aimed
Li Ru, Li Ru, Ruotong Liu, Haoyu Xing, Yueming Yuan, Yueming Yuan, Zheng Yuan, Zhiyong Xu, Qin Xu, Jianping Song, Xiaobo Li, Xiaobo Li, Xiaobo Li   +12 more
doaj   +1 more source

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Drakeley, Chris J, Bousema, Teun, Sutherland, CJ, Lucy C Okell, Bousema, T, Ghani, Azra C, Sutherland Colin J, Drakeley Chris J, Drakeley, CJ, Colin J Sutherland, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Sutherland, Colin J, Ghani Azra C, Ghani, AC, Teun Bousema, Okell, LC, Chris J Drakeley   +19 more
core   +1 more source