Results 21 to 30 of about 37,512 (201)

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Research, 2023
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after ...
Chong Qiu, Fei Xia, Junzhe Zhang, Qiaoli Shi, Yuqing Meng, Chen Wang, Huanhuan Pang, Liwei Gu, Chengchao Xu, Qiuyan Guo, Jigang Wang   +10 more
doaj   +1 more source

Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release [PDF]

, 2022
Immune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system is thought to cause a damaging invasion of immune ...
Vilar, B., Cunningham, K.P., Shankar-Hari, M., Luqman, S., McNaughton, P.A., Morad, H.O.J., Pinto, L.G., Clayton, G.   +7 more
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Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Journal of Neuroinflammation, 2021
Background Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained the bioactivity of the parent compound, the targets of cel in cerebral ...
Dan-Dan Liu, Piao Luo, Liwei Gu, Qian Zhang, Peng Gao, Yongping Zhu, Xiao Chen, Qiuyan Guo, Junzhe Zhang, Nan Ma, Jigang Wang   +10 more
doaj   +1 more source

A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

Journal of Pharmaceutical Analysis, 2022
The composition of serum is extremely complex, which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and diagnosis.
Yuqing Meng, Jiayun Chen, Yanqing Liu, Yongping Zhu, Yin-Kwan Wong, Haining Lyu, Qiaoli Shi, Fei Xia, Liwei Gu, Xinwei Zhang, Peng Gao, Huan Tang, Qiuyan Guo, Chong Qiu, Chengchao Xu, Xiao He, Junzhe Zhang, Jigang Wang   +17 more
doaj   +1 more source

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria : a literature review and meta-analysis of individual patient data [PDF]

, 2015
Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin.
Wwarn Artemisinin based Combination Therapy Africa Baseline Stud,
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Artemisinin antimalarials: preserving the "magic bullet" [PDF]

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
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Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin

Microbiology Spectrum, 2021
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in countries of endemicity.
Lina Chen, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Yu Zhang, Liu Tuo, Yongdan Zhao, Yujie Li   +10 more
doaj   +1 more source

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. [PDF]

, 2006
Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa.
Mugittu, Kefas, Beck, Hans Peter, Mugittu Kefas, Hassan Mshinda, Hans Beck, Mshinda Hassan, Blaise Genton, Kefas Mugittu, Genton Blaise, Beck Hans, Mshinda, Hassan, Genton, Blaise   +11 more
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Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives

Frontiers in Chemistry, 2023
Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of artemisinin were undertaken to obtain a series of artemisinin ...
Xinna Gao, Xinna Gao, Yue Bai, Peng Sun, Huimin Gao, Lan Yang, Dong Zhang, Yifan Zhao, Yue Ma   +8 more
doaj   +1 more source

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors [PDF]

, 2010
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins.
Herpen, T.W.J.M., van, Nogueira, M., Teun W J M van Herpen, van Herpen Teun W. J. M., Harro J. Bouwmeester, Cankar, Katarina, Katarina Cankar, Harpen, Teun W. J. M. van, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Bouwmeester Harro J., Beekwilder, Jules, Jules Beekwilder, Teun W. J. M. van Herpen, Nogueira Marilise, Cankar, K., van Herpen, T.W.J.M., Cankar Katarina, Beekwilder Jules, Bouwmeester, Harro, Nogueira, Marilise, Bosch, H.J., Bosch Dirk, Bouwmeester, H.J., Beekwilder, M.J., Bosch, Dirk   +26 more
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