Results 51 to 60 of about 28,538 (185)

Neurotoxicity of Artemisinin Derivatives [PDF]

Clinical Infectious Diseases, 2006
tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng, Goka, Bamenla Q, Kurtzhals, Jørgen   +2 more
openaire   +3 more sources

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo

BMC Complementary Medicine and Therapies
Background Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality.
Chuyi Yu, Haoyu Xing, Xiaguo Fu, Yingying Zhang, Xiufang Yan, Jianjia Feng, Zhouqin He, Li Ru, Chunlong Huang, Jianming Liang   +9 more
doaj   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Allicin-based biomimetic nanoparticles of the erythrocyte membrane for the delivery of lumefantrine to enhance its antimalarial effect

International Journal of Pharmaceutics: X
Owing to the emergence of drug resistance and the lack of effective vaccines, malaria continues to seriously harm the physical and mental health of a multitude of individuals, warranting the need to explore new antimalarial strategies.
Chuyi Yu, Xiaobo Li, Keneng Cai, Weichi Jiang, Wanying Chen, Run Xia, Mengyao Xu, Jianjia Feng, Chengli Ling, Sheng Zhou, Yinhuan Chen, Feng Zeng, Qin Xu, Xiao He, Mingqiang Li, Jianping Song, Jianming Liang   +16 more
doaj   +1 more source

Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinin content. [PDF]

PLoS ONE, 2013
Artemisia annua is the source of antimalarial phytomolecule, artemisinin. It is mainly produced and stored in the glandular secretory trichomes present in the leaves of the plant.
Priya Nair, Amita Misra, Alka Singh, Ashutosh K Shukla, Madan M Gupta, Anil K Gupta, Vikrant Gupta, Suman P S Khanuja, Ajit K Shasany   +8 more
doaj   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Construction of an uricase/catalase/curcumin-co-loaded drug delivery system and its effect on hyper-uric acid-induced kidney injury

Smart Materials in Medicine
Hyper-uric acid (UA)-induced kidney injury (HAKI) is caused by the deposition of excess blood UA into the kidneys. We confined molecules of uricase (URI), catalase (CAT), and curcumin (Cur) to a single structure (UC/Cur) while retaining their enzymatic ...
Yang Zhang, Xiaobo Li, Chunling Liang, Jianjia Feng, Chuyi Yu, Weichi Jiang, Keneng Cai, Wanying Chen, Wenli Cai, Feng Zeng, Qin Xu, Peng Chen, Jianming Liang   +12 more
doaj   +1 more source

A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial. [PDF]

PLoS Medicine, 2011
Artemisinin-based combination therapies (ACTs) are the mainstay for the management of uncomplicated malaria cases. However, up-to-date data able to assist sub-Saharan African countries formulating appropriate antimalarial drug policies are scarce.Between
Four Artemisinin-Based Combinations (4ABC) Study Group
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source