Results 71 to 80 of about 37,512 (201)

Neurotoxicity of Artemisinin Derivatives [PDF]

Clinical Infectious Diseases, 2006
tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng, Goka, Bamenla Q, Kurtzhals, Jørgen   +2 more
openaire   +3 more sources

Discovery and repurposing of artemisinin

Frontiers of Medicine, 2022
Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the "best hope for the treatment of malaria" by World Health Organization.
Shi, Qiaoli, Xia, Fei, Wang, Qixin, Liao, Fulong, Guo, Qiuyan, Xu, Chengchao, Wang, Jigang   +6 more
openaire   +2 more sources

Artemisinin-mediated knockdown of ERα expression and its consequent effects on Bcl-2 and cyclin D1 expression in MCF-7_CC-7 and MCF-7_CC-12 cells. [PDF]

, 2017
(A) MCF-7CC-7 and MCF-7CC-12 cells were treated with either DMSO or 300 μM artemisinin. Whole cell extracts of these cells were then monitored for Bcl-2, cyclin D1, and γ tubulin protein expression using immunoblotting approaches with epitope-specific ...
Simon Chewchuk (3746674), Baoqing Guo (3518801), Amadeo Mark Parissenti (3746671)   +2 more
core   +1 more source

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo

BMC Complementary Medicine and Therapies
Background Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality.
Chuyi Yu, Haoyu Xing, Xiaguo Fu, Yingying Zhang, Xiufang Yan, Jianjia Feng, Zhouqin He, Li Ru, Chunlong Huang, Jianming Liang   +9 more
doaj   +1 more source

The safety of artemisinins during pregnancy: a pressing question. [PDF]

, 2007
BACKGROUND: An increasing number of countries in sub-Saharan Africa are changing to artemisinins combination therapy (ACT) as first or second line treatment for malaria.
Dellicour, Stephanie, Chandramohan, Daniel, Stephanie Dellicour, Dellicour Stephanie, Daniel Chandramohan, Hall, Susan, Greenwood Brian, Greenwood, Brian, Brian Greenwood, Hall Susan, Chandramohan Daniel, Susan Hall   +11 more
core   +1 more source

Allicin-based biomimetic nanoparticles of the erythrocyte membrane for the delivery of lumefantrine to enhance its antimalarial effect

International Journal of Pharmaceutics: X
Owing to the emergence of drug resistance and the lack of effective vaccines, malaria continues to seriously harm the physical and mental health of a multitude of individuals, warranting the need to explore new antimalarial strategies.
Chuyi Yu, Xiaobo Li, Keneng Cai, Weichi Jiang, Wanying Chen, Run Xia, Mengyao Xu, Jianjia Feng, Chengli Ling, Sheng Zhou, Yinhuan Chen, Feng Zeng, Qin Xu, Xiao He, Mingqiang Li, Jianping Song, Jianming Liang   +16 more
doaj   +1 more source

Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study. [PDF]

, 2012
BACKGROUND: Artemisinin-based combination therapy (ACT) has been promoted as a means to reduce malaria transmission due to their ability to kill both asexual blood stages of malaria parasites, which sustain infections over long periods and the immature ...
Mwita, A., Elling, B.F., MacArthur, John R, Mwita, Alex, Mills, Anne, Tanner, M., Goodman, C. A., Roberts, J.M., Skarbinski, J., Elling, B. F., Elling, Berty F, Kahigwa, E., Roberts, J. M., Lyimo, T., Khatib, R.A., Njau, J. D., Somi, Masha F, Kahigwa, Elizeus, Njau, J.D., Macarthur, J. R., Somi, M.F., Kachur, S Patrick, Roberts, Jacquelin M, Skarbinski, Jacek, Goodman, Catherine A, Kabanywanyi, Abdunoor M, Smith, Ernest E, Goodman, C.A., Genton, B., Abdulla, S. M., Bloland, Peter B, Gutman, J. R., Kabanywanyi, A.M., Gutman, J.R., Lyimo, Thomas, Kachur, S.P., Bloland, P.B., Njau, Joseph D, Bloland, P. B., Mshinda, Hassan, Genton, Blaise, Tanner, Marcel, MacArthur, J.R., Somi, M. F., Abdulla, Salim M, Smith, E. E., Smith, E.E., Kachur, S. P., Kabanywanyi, A. M., Khatib, R. A., Mshinda, H., Gutman, Julie R, Abdulla, S.M., Mills, A., Khatib, Rashid A   +54 more
core   +1 more source

Construction of an uricase/catalase/curcumin-co-loaded drug delivery system and its effect on hyper-uric acid-induced kidney injury

Smart Materials in Medicine
Hyper-uric acid (UA)-induced kidney injury (HAKI) is caused by the deposition of excess blood UA into the kidneys. We confined molecules of uricase (URI), catalase (CAT), and curcumin (Cur) to a single structure (UC/Cur) while retaining their enzymatic ...
Yang Zhang, Xiaobo Li, Chunling Liang, Jianjia Feng, Chuyi Yu, Weichi Jiang, Keneng Cai, Wanying Chen, Wenli Cai, Feng Zeng, Qin Xu, Peng Chen, Jianming Liang   +12 more
doaj   +1 more source

Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinin content. [PDF]

PLoS ONE, 2013
Artemisia annua is the source of antimalarial phytomolecule, artemisinin. It is mainly produced and stored in the glandular secretory trichomes present in the leaves of the plant.
Priya Nair, Amita Misra, Alka Singh, Ashutosh K Shukla, Madan M Gupta, Anil K Gupta, Vikrant Gupta, Suman P S Khanuja, Ajit K Shasany   +8 more
doaj   +1 more source