Results 81 to 90 of about 28,538 (185)
ChemMedChem, Volume 21, Issue 18, 28 September 2026.Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales +7 more
wiley +1 more source
Journal of NanobiotechnologyRheumatoid arthritis (RA) is characterized by elevated levels of reactive oxygen species (ROS) and a persistent inflammatory microenvironment dominated by M1 macrophages, both of which contribute to disease progression.
Xiaoru Zhang +7 more
doaj +1 more source
Tropical Medicine and Infectious DiseaseBackground: Recent setbacks in malaria control in Comoros demand a reassessment of its evolving epidemiology. Methods: Using the Global Burden of Disease (GBD) Study 2021 data, we analyzed malaria trends from 2010 to 2021, stratified by sex.
Sheng Zhou +8 more
doaj +1 more source
N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands
ChemBioChem, Volume 27, Issue 17, 14 September 2026.A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier +10 more
wiley +1 more source
Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds
European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski +10 more
wiley +1 more source
Molecules, 2019 Dihydroartemisinin (DHA) is a derivative of the herb Artemisia annua L. that has prominent immunomodulatory activity; however, its underlying mechanism remains elusive.
Si Chao Yan +8 more
doaj +1 more source
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994 The compounds derived from the Chinese medicinal plant qinghao (Artemisia annua) are the most rapidly acting of all antimalarial drugs. They are effective when given parenterally, orally or by suppository. No serious adverse effect has yet been reported in humans.
openaire +2 more sources
Intrarectal artemisinin derivatives.
Medecine tropicale : revue du Corps de sante colonial, 1998 The artemisinin derivatives are the most potent antimalarials. They are rapidly absorbed orally, parenterally and intra-rectally. The latter mode of administration is particularly interesting in rural tropics. Preliminary studies have shown that artemisinin and its derivatives artesunate and artemether are effective when given intrarectally.
Nosten, F, van Vugt, M, White, N
openaire +3 more sources
Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review). [PDF]
Mol Med RepCao S, Yang M, Qu S, Wu J, Li J, Zhao Y.
europepmc +1 more source
Artemisinins inhibited the synergistic cariogenic effect between <i>Candida albicans</i> and <i>Streptococcus mutans</i>. [PDF]
Front Cell Infect MicrobiolZhou J +11 more
europepmc +1 more source