Results 61 to 70 of about 37,512 (201)

Magnetic Nanoparticle-Based Ligand Replacement Strategy for Chemical Luminescence Determination of Cholesterol

Frontiers in Chemistry, 2020
Determination of serum cholesterol (Chol) is important for disease diagnosis, and has attracted great attention during the last few decades. Herein, a new magnetic nanoparticle-based ligand replacement strategy has been presented for chemical ...
Yalan Wu, Danfeng Peng, Zhiwen Qi, Jing Zhao, Wenyi Huang, Ying Zhang, Changhui Liu, Tao Deng, Fang Liu   +8 more
doaj   +1 more source

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Molecules, 2022
Malaria is a life-threatening disease. Artemisinin-based combination therapy (ACT) is the preferred choice for malaria treatment recommended by the World Health Organization.
Le Zhao, Yunhao Zhu, Haoyu Jia, Yongguang Han, Xiaoke Zheng, Min Wang, Weisheng Feng   +6 more
doaj   +1 more source

Priority Setting for the Implementation of Artemisinin-Based Combination Therapy Policy in Tanzania: Evaluation Against the Accountability for Reasonableness Framework. [PDF]

, 2012
\ud Priority setting for artemisinin-based antimalarial drugs has become an integral part of malaria treatment policy change in malaria-endemic countries. Although these drugs are more efficacious, they are also more costly than the failing drugs.
Mori Amani, Kaale, E.A., Mori, Amani Thomas, Amani Thomas Mori, Kaale, Eliangiringa Amos, Mori, A.T., Kaale Eliangiringa, Eliangiringa Amos Kaale   +7 more
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Fu-zi decoction attenuate rheumatoid arthritis in vivo and in vitro by modulating RANK/RANKL signaling pathway

Frontiers in Pharmacology
BackgroundFu-zi decoction (FZD) has a long history of application for treating Rheumatoid arthritis (RA) as a classic formulation. However, its underlying mechanisms have not been fully elucidated.
Zhenzhen Pan, Zhenzhen Pan, Fangchan Li, Yujie Xu, Huimin Ye, Jiahui Liu, Zhenhua Wang, Changsheng Deng, Jianping Song, Manxue Mei, Changqing Li   +10 more
doaj   +1 more source

The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway

Frontiers in Pharmacology, 2021
Background and Purpose: Ultrafine particulate matter (UFPM) induces oxidative stress (OS) and is considered to be a risk factor of myocardial ischemia (MI). Shengmai formula (SMF) is a traditional Chinese medicine with antioxidant properties and has been
Lina Chen, Lina Chen, Yuan Guo, Yuan Guo, Shuiqing Qu, Shuiqing Qu, Kai Li, Kai Li, Ting Yang, Ting Yang, Yuanmin Yang, Yuanmin Yang, Zhongyuan Zheng, Zhongyuan Zheng, Hui Liu, Hui Liu, Xi Wang, Xi Wang, Shuoqiu Deng, Shuoqiu Deng, Yu Zhang, Yu Zhang, Xiaoxin Zhu, Xiaoxin Zhu, Yujie Li, Yujie Li   +25 more
doaj   +1 more source

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission [PDF]

, 2012
<p>Background: Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infections and reducing the ...
Huho, B. J., Charlwood, J Derek, Kihonda, Japhet, Adriana Tami, Christian Lengeler, Huho, B.J., Huho Bernadette J, Heather M Ferguson, Smith, T., Tami, A., Lengeler Christian, Killeen, G. F., Abdulla, Salim M. K., Killeen, Gerard F., J Derek Charlwood, Lengeler, Christian, Aniset Kihonda, Smith, T. A., Salim MK Abdulla, Huho, Bernadette J., Kachur, S Patrick, Charlwood J Derek, Japhet Kihonda, Charlwood, J D, Charlwood, D.J., Smith, Thomas A, Thomas A Smith, Ferguson, Heather M, Killeen, G.F., Abdulla, S. M., Abdulla, S.K., Abdulla, Salim MK, Ferguson, H., Killeen Gerard F, Kihonda, A., Kachur, S.P., Huho, Bernadette J, Kihonda, J., Killeen, Gerry, Abdulla Salim MK, Kachur S Patrick, Smith, Thomas A., Killeen, Gerard F, Kihonda Japhet, Tami, Adriana, Kihonda Aniset, Gerard F Killeen, Tami Adriana, S Patrick Kachur, Charlwood, J. Derek, Lengeler, C., Ferguson, Heather M., Kachur, S. Patrick, Kihonda, Anisette, Ferguson Heather M, Abdulla, Salim M, Kihonda, Aniset, Ferguson, H. M., Charlwood, J. D., Kachur, S. P., Tami, Adriana; id_orcid, Smith Thomas A, Bernadette J Huho   +62 more
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Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

Journal of Experimental & Clinical Cancer Research, 2023
Background There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribute to the progression of CRLM.
Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu, Yongzhuo Huang   +9 more
doaj   +1 more source

Metabolic regulation and engineering of artemisinin biosynthesis in A. annua

Medicinal Plant Biology, 2023
Artemisinin is a potent anti-malarial sesquiterpene lactone that is naturally biosynthesized in glandular trichomes of a Chinese herbal plant, Artemisia annua. Although semi-synthesis of artemisinin in yeast has been feasible, at present the A.
Yueli Tang, Lien Xiang, Fangyuan Zhang, Kexuan Tang, Zhihua Liao   +4 more
doaj   +1 more source

Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity. [PDF]

, 2008
BACKGROUND: Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With
Drakeley, Chris J, Bousema, Teun, Lucy C Okell, Bousema, T, Ghani, Azra C, Drakeley Chris J, Drakeley, CJ, Christopher J M Whitty, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Ghani, AC, Whitty Christopher J. M, Ghani Azra C, Teun Bousema, Whitty, Christopher JM, Okell, LC, Whitty, CJ, Christopher J. M Whitty, Chris J Drakeley   +20 more
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Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. [PDF]

, 2022
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity.
Ren, Xiao-Dong, Horrocks, Paul, Woodfine, Sian, Luo, Jiaer, Mobley, Rebecca, Drijfhout, Falko, Li, Wen-Wu   +6 more
core   +1 more source