Results 61 to 70 of about 28,538 (185)

MicroRNA-32-5p inhibits metastasis by directly targeting VPS4B and increases sensitivity to dihydroartemisinin in neuroblastoma

Science of Traditional Chinese Medicine
. Background. Neuroblastoma (NB) is a malignant pediatric tumor requiring new therapies. Accumulating evidence has confirmed that microRNAs play critical roles in NB metastasis.
Lina Chen, Hui Liu, Zhongyuan Zheng, Shuiqing Qu, Yu Zhang, Shuoqiu Deng, Shuo Shen, Tuo Liu, Yue Dai, Yu Li, Honghua Cui, Yujie Li   +11 more
doaj   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

A non-randomized, open-label study to assess the impact of rounds of mass drug administration with artemisinin-piperaquine plus primaquine on malaria in São Tomé Island

Parasites & Vectors
Background The aim of this study was to explore the effect of mass drug administration (MDA) on malaria transmission in low-endemic malaria areas. Methods Mass drug administration of artemisinin-piperaquine (AP) + primaquine (PMQ) was targeted to 17,438 ...
Mingqiang Li, Ruixiang Tan, Peiting Chen, Herodes Sacramento Rampao, Carlos Alberto Bandeira D’almeida, Guoming Li, Jingwen Liu, Guozhuang Shi, Fei Chen, Lei Shu, Xinan Huang, Changsheng Deng, Wenfeng Guo, Jianping Song   +13 more
doaj   +1 more source

Simultaneous Quantitative Determination of Six Caffeoylquinic Acids in Matricaria chamomilla L. with High-Performance Liquid Chromatography

Journal of Chemistry, 2019
A simple and effective method for the simultaneous quantitative analysis of six caffeoylquinic acids (CAs) in Matricaria chamomilla L. (M. chamomilla) using high-performance liquid chromatography (HPLC) with diode-array detection (DAD) was established ...
Yifan Zhao, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Yue Bai, Dong Zhang, Lan Yang   +7 more
doaj   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Artemisinin

HIMALAYA, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine.
openaire   +1 more source

Tonoplast‐Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT The plant‐derived specialized metabolite montbretin A (MbA) is under development as an improved treatment for Type 2 diabetes, a worldwide epidemic. MbA is an acylated flavonol glycoside so far only found in small amounts in montbretia (Crocosmia × crocosmiiflora) corms.
Charlotte Hijmans, Filipe Cabrita Cruz, Lars H. Kruse, Joerg Bohlmann, Sandra Irmisch   +4 more
wiley   +1 more source

Red and Blue Light Promote the Accumulation of Artemisinin in Artemisia annua L.

Molecules, 2018
Artemisinin, which has been isolated from Artemisia annua L., is the most effective antimalarial drug and has saved millions of lives. In addition, artemisinin and its derivatives have anti-tumor, anti-parasitic, anti-fibrosis, and anti-arrhythmic ...
Dong Zhang, Wei Sun, Yuhua Shi, Lan Wu, Tianyuan Zhang, Li Xiang   +5 more
doaj   +1 more source