Results 91 to 100 of about 37,512 (201)

Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites. [PDF]

, 2008
BACKGROUND: The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings.
Yusuf, Bidemi, Doamekpor, Leticia, Ikeoluwapo O Ajayi, Cousens, Simon, Fred Bateganya, Andrew Balyeku, Edmund N Browne, Peter Agyei-Baffour, Agyei-Baffour, Peter, Leticia Doamekpor, Browne, Edmund N, Kaendi Munguti, Balyeku, Andrew, Garshong, Bertha, Bertha Garshong, Franco Pagnoni, Bateganya, Fred, Pagnoni, Franco, Ajayi, Ikeoluwapo O, Simon Cousens, Munguti, Kaendi, Bidemi Yusuf   +21 more
core   +1 more source

A new geography of pharmaceuticals : Trajectories of artemisinin-based medicines [PDF]

, 2021
International audienceThe geography of artemisinin-based drug innovation and industry is uniquely distributed. Originally developed in China, it was subsequently globalized through the WHO, humanitarian medicine, and the multinational pharmaceutical ...
Cassier, Maurice
core   +2 more sources

Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy [PDF]

, 2009
Background Change of first-line treatment of uncomplicated malaria to artemisinin-combination therapy (ACT) is widespread in Africa. To expand knowledge of safety profiles of ACT, pharmacovigilance activities are included in the implementation process of
Fogg Carole, Kodua Augustina, Asiimwe, Alex, Dodoo, A., Ofori Tenkorang, David Ofori-Adjei, Tenkorang Ofori, Edmund T Nartey, Ofori-Adjei David, Alex Asiimwe, Tenkorang, O., Alexander NO Dodoo, Nartey Edmund T, Nartey, E., Augustina Kodua, Asiimwe Alex, Carole Fogg, Kodua, A., Dodoo Alexander NO, Ofori-Adjei, D., Fogg, Carole   +20 more
core   +1 more source

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. [PDF]

, 2012
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.
Yeang, Chhiang, Shunmay Yeung, Nguon, Sokomar, Chea, Nguon, Thomson Andrew, Chhiang Yeang (130756), Steven Bjorge (130709), Khim Nimol, Samphornarann Top (130727), Habib, Najibullah, Robert D Newman, Andrew Thomson (23309), Menard, Didier, Sovann Yok, Kim Saorin, Kim, Saorin, Sophal, Uth, Bjorge Steven, Benoit Witkowski, Didier Menard (2577220), Najibullah Habib, Michelle M Thompson, Steven Bjorge, Sarorn Sum, Didier Menard, Nimol Khim (130700), Andrew Thomson, Christophel Eva-Maria, Ros, Seyha, Mellor Steve, Top Samphornarann, Hoyer Stefan, Bjorge, Steven, Socheat Duong, Saorin Kim, Menard Didier, Kheng, Sim, Nguon Chea, Hoyer, Stefan, Top, Samphornarann, Sokomar Nguon, Najibullah Habib (130696), Thompson Michelle M., Robert D. Newman (130763), Sarorn Sum (130703), Sophal Uth, Witkowski Benoit, Witkowski, Benoit, Sovann Yok (130723), Socheat Duong (130761), Newman, Robert D, Nguon Sokomar, Uth Sophal, Michelle M. Thompson, Michelle M. Thompson (130739), Duong, Socheat, Kheng Sim, Seyha Ros (130731), Mellor, Steve, Yeung, Shunmay, Chhiang Yeang, Ariey Frédéric, Seyha Ros, Samphornarann Top, Saorin Kim (130692), Christophel, Eva-Maria, Khim, Nimol, Steve Mellor, Sim Kheng (130715), Uth Sophal (130734), Chea Nguon, Eva-Maria Christophel, Nguon Chea (130719), Yok Sovann, Frédéric Ariey (92228), Ros Seyha, Sum, Sarorn, Nimol Khim, Thomson, Andrew, Frédéric Ariey, Yeang Chhiang, Newman Robert D., Sum Sarorn, Thompson, Michelle M, Habib Najibullah, Ariey, Frédéric, Duong Socheat, Yeung Shunmay, Eva-Maria Christophel (130705), Sim Kheng, Sokomar Nguon (130689), Stefan Hoyer (130687), Stefan Hoyer, Yok, Sovann, Robert D. Newman, Steve Mellor (130744), Benoit Witkowski (130751), Shunmay Yeung (53391)   +97 more
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Singlet oxygen as a signaling transducer for modulating artemisinin biosynthetic genes in Artemisia annua [PDF]

, 2011
Although crosstalk between cytosolic and plastidic terpenoid pathways has been validated in many plant species, we report here for the first time a striking elevation of the nucleus-encoded artemisinin biosynthesis relevant DBR2 mRNA following the ...
X. -Q. Yang, Q. -P. Zeng, X. -M. Zeng, R. -Y. Yang   +3 more
core   +1 more source

Artemisinin-based combinations

Current Opinion in Infectious Diseases, 2005
Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world.A large multicentre randomised trial conducted in East Asia has shown a 35% reduction in mortality from severe malaria ...
Ashley, E, White, N
openaire   +3 more sources

Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes of Artemisia annua [PDF]

, 2009
Artemisinin has been proven to be an effective antimalarial compound, especially for chloroquine-resistant and cerebral malaria. However, its biosynthesis pathway is still not completely clear.
许国旺, Ye, Hechun, Guowang Xu, Ma, Lanqing, Hechun Ye, Liu, Benye, Lanqing Ma, Benye Liu, Chenfei Ma, Li, Guofeng, Huahong Wang, Zhigao Du, Ma, Chenfei, Wang, Hong, Wang, Huahong, Du, Zhigao, Hong Wang, Guofeng Li, Xu, Guowang   +18 more
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Who Gets Prompt Access to Artemisinin-based Combination Therapy? A Prospective Community-Based Study in Children from Rural Kilosa, Tanzania. [PDF]

, 2010
Effective and timely case management remains one of the fundamental pillars for control of malaria. Tanzania introduced artemisinin-combination therapy [ACT] for uncomplicated malaria; however, the policy change is challenged by limited availability of ...
Zul Premji, Zakayo Mrango, Simba, D.O., Marian Warsame, Tomson, G., Goran Tomson, Kakoko, Deodatus, Deodatus Kakoko, Petzold, M., Tomson, Goran, Premji, Z., Premji Zul, Premji, Zul, Mrango, Z., Simba, Daudi O, Petzold, Max, Warsame, Marian, Petzold Max, Daudi O. Simba, Warsame Marian, Tomson Goran, Warsame, M., Max Petzold, Simba Daudi O., Mrango, Zakayo, Mrango Zakayo, Kakoko, D., Daudi O Simba, Kakoko Deodatus   +28 more
core   +1 more source

Changes in Malaria Patterns in Comoros from 2010 to 2021: A Comparative Study with Sub-Saharan Africa

Tropical Medicine and Infectious Disease
Background: Recent setbacks in malaria control in Comoros demand a reassessment of its evolving epidemiology. Methods: Using the Global Burden of Disease (GBD) Study 2021 data, we analyzed malaria trends from 2010 to 2021, stratified by sex.
Sheng Zhou, Linxin Yu, Jianming Liang, Wei Xie, Guoming Li, Changsheng Deng, Jianping Song, Guanyang Zou, Yinhuan Chen   +8 more
doaj   +1 more source

Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Pharmaceutical Sciences, 2016
Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles
Hamid Reza Kheiri Manjili 1, Hojjat Malvandi 3, Mir-Sajjad Mosavi 1, Hossein Danafar 2,3 *
doaj   +1 more source