Results 121 to 130 of about 2,234,657 (224)

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery

Infection and Drug Resistance, 2020
Melkamu Adigo Shibeshi, Zemene Demelash Kifle, Seyfe Asrade Atnafie Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Zemene Demelash KifleDepartment of ...
Shibeshi MA, Kifle ZD, Atnafie SA
doaj  

ANTI-MALARIAL DRUG RESISTANCE

Majalah Kedokteran Andalas, 2014
AbstrakTujuan studi ini adalah untuk menjelaskan mekanisme resistensi parasit malaria danusaha-usaha yang dapat dilakukan untuk menghadapi munculnya strain parasit yangresisten terhadap artemisinin.
Yenni Yusuf
doaj   +1 more source

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. [PDF]

, 2011
Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is not compromised by
CALLY ROPER, Naidoo, Inbarani, Roper, Cally, INBARANI NAIDOO   +3 more
core   +1 more source

Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved]

F1000Research, 2018
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Emily S. Mathews, Audrey R. Odom John
doaj   +1 more source

Plasmodium malariae structure and genetic diversity in sub-Saharan Africa determined from microsatellite variants and linked SNPs in orthologues of antimalarial resistance genes. [PDF]

Sci Rep, 2022
Oriero EC, Demba MA, Diop MF, Ishengoma DS, Amenga-Etego LN, Ghansah A, Apinjoh T, Issiaka S, Djimde A, D'Alessandro U, Meremikwu M, Amambua-Ngwa A.   +11 more
europepmc   +2 more sources

A randomised controlled trial to compare the efficacy, safety, and tolerability of low dose, short course primaquine in adults with uncomplicated P. vivax malaria in two hospitals in India

Trials
Background Plasmodium vivax remains a major challenge for malaria control and elimination due to its ability to cause relapsing illness. To prevent relapses the Indian National Center for Vector Borne Diseases Control (NCVBDC) recommends treatment with ...
Sundus Shafat Ahmad, Reena Verma, Robert J. Commons, Nitika, Sauman Singh-Phulgenda, Rutuja Chhajed, Praveen K. Bharti, Beauty Behera, Syed Mohammad Naser, Salil Kumar Pal, Parinita Halder Ranjit, Rajendra Kumar Baharia, Bhavin Solanki, K. J. Upadhyay, Philippe J. Guerin, Amit Sharma, Ric N. Price, Manju Rahi, Kamala Thriemer   +18 more
doaj   +1 more source

Current developments on antimalarial drugs and mechanisms of resistance to antimalarials

Microbes and Infectious Diseases
Background: Antimalarial drugs are key tools for the control and elimination of malaria. Widespread and indiscriminate use of antimalarial drugs makes malaria parasites to evolve mechanisms of resistance. Currently, there are many new antimalarial drug targets; these include malaria parasite proteases, Phosphatidylinositol 4‑kinase (PfPI4K) Inhibitors,
openaire   +2 more sources

Should New Anti-Malarial Drugs be Subsidized? [PDF]

We use analytical and numerical models to explain and quantify the welfare effects of subsidies for artemisinin combination treatments (ACTs), a valuable new class of antimalarial drugs.
Klein, Eili, Parry, Ian W.H., Smith, David L., Laxminarayan, Ramanan   +3 more
core  

Antimalarial drug resistance and combination chemotherapy

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
Antimarial drug resistance develops when spontaneously occurring parasite mutants with reduced susceptibility are selected, and are then transmitted. Drugs for which a single point mutation confers a marked reduction in susceptibility are particularly vulnerable.
openaire   +3 more sources

Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies [PDF]

, 2010
Includes bibliographical references.Malaria remains one of the most devastating tropical diseases, with staggering infection and mortality statistics. Over 200 million clinical cases of malaria (resulting in 1 - 3 million deaths) are reported annually ...
Guantai, Eric
core   +1 more source