Results 181 to 190 of about 2,234,657 (224)

Development of Semisynthetic Blasticidin S Analogs with Potent and Fast-Killing Antimalarial Activity. [PDF]

ACS Infect Dis
Fike KR, Gannett C, Kiselka AM, Tiller K, Ajasa T, Weger-Lucarelli J, Brown AM, Lowell AN, Klemba M.   +8 more
europepmc   +1 more source

Recurrent parasitemias with artemisinin partial resistance mutations during the 2024 Ethiopia malaria resurgence: a case series. [PDF]

Malar J
Geleta D, Brhane BG, Abera A, Belachew M, Sime H, Gebreegziaxher A, Getu M, Ali A, Tesfay N, Habtetsion M, Kokobe B, Kebede M, Worku Z, Tasew G, Tadesse G, Tollera G, Fola AA, Bailey JA, Juliano JJ, Parr JB, Abte M, Assefa A.   +21 more
europepmc   +1 more source

Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review). [PDF]

Mol Med Rep
Cao S, Yang M, Qu S, Wu J, Li J, Zhao Y.
europepmc   +1 more source

Using Unbiased Chemical Proteomics Approaches to Explore the Target Landscape of the Resistance Refractory 7-Azaindole MMV022224 in <i><i>Plasmodium falciparum</i></i>. [PDF]

ACS Infect Dis
Syed AJ, Milne R, Corpas-Lopez V, Dey G, Boonyalai N, Wall RJ, Wiedemar N, Montejo L, Nardella F, Wicht KJ, Pasaje CFA, Okombo J, Niles JC, Fidock DA, Lee MCS, Chakrabarti D, Patterson S, Wyllie S.   +17 more
europepmc   +1 more source

Chemoselective halogenation of premarineosin A for next-generation antimalarial development.

Org Biomol Chem
Harris NR, Amin S, Curtis BJ, Teklemichael AA, Dranchak P, McBride CM, Verhey-Henke L, Warrell CJ, Dulaney WM, Oliphant EN, Inglese J, Su XZ, Sherman DH, Pereira F.   +13 more
europepmc   +1 more source

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History and importance of antimalarial drug resistance

Tropical Medicine and International Health, 2001
The emergence of Plasmodium falciparum resistance to widely used antimalarial drugs such as chloroquine (CQ) has made malaria control and treatment much more difficult. This is particularly dramatic for Africa, as few affordable alternatives are available.
Umberto D'Alessandro
exaly   +4 more sources

Uncovering the ART of antimalarial resistance

Science, 2020
A key mechanism of resistance to the antimalarial drug artemisinin is ...
Danushka, Marapana, Alan F, Cowman
openaire   +2 more sources

[Antimalarial drug resistance].

Medecine et maladies infectieuses, 2006
Drug resistant malaria is mostly due to Plasmodium falciparum, the highly prevalent species in tropical Africa, Amazon, and Southeast Asia. P. falciparum is responsible for severe involvement of fever or anemia causing more than a million deaths per year.
Le Bras, J., Musset, L., Clain, J.
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The prevention of antimalarial drug resistance

Pharmacology & Therapeutics, 1990
The deployment of antiprotozoal drugs on a large scale for prophylaxis or monotherapy inevitably results in the selection of drug-resistance. The use of appropriately selected drug combinations may impede this process. Point mutations underlie resistance to dihydrofolate reductase inhibitors such as pyrimethamine.
openaire   +2 more sources

The origins of antimalarial drug resistance

Trends in Parasitology, 2004
Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine-pyrimethamine is a result of extremely rare mutations that have spread over large geographical areas. This pattern was completely unexpected because mutations encoding resistance occur commonly in laboratory conditions, leading to the expectation that resistance would originate ...
openaire   +2 more sources