Results 191 to 200 of about 2,234,657 (224)
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Economic Implications of Resistance to Antimalarial Drugs
PharmacoEconomics, 1996The widespread evolution of drug resistance in malarial parasites has seriously hampered efforts to control this debilitating disease. Chloroquine, the mainstay of malaria treatment for many decades, is now proving largely ineffective in many parts of the world, particularly against the most severe form of malaria--falciparum.
M, Phillips, P A, Phillips-Howard
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In Vivo Assessments to Detect Antimalarial Resistance
2019In vivo drug clinical trials are the gold standard for assessing the therapeutic efficacy of antimalarials. They must be conducted in a rigorous and standardized manner so that the resistance of antimalarial drugs can be compared both in time and in space.
Dhorda, M, Dondorp, A
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The Origins of Antimalarial-Drug Resistance
New England Journal of Medicine, 2014There is a tendency to view the development of antimalarial-drug resistance as an inevitable outcome of the drugs' widespread use. Yet resistance has been accelerated by the way the drugs are used and by the social and economic conditions in which they are used.
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Resistance to antimalarial compounds: Methods and applications
Drug Resistance Updates, 2009Considerable progress has been made in antimalarial research; however, much more effort is required to develop new antimalarials which overcome plasmodial resistance to clinically available drugs and limit the emergence of resistance. In particular, research must focus on understanding the mechanisms by which Plasmodium falciparum impedes the action of
Benoit, Witkowski +2 more
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Improving Surveillance for Antimalarial Drug Resistance
JAMA, 2007GLOBAL MALARIA CONTROL EFFORTS DEPEND INcreasingly on artemisinin derivatives because of resistance to other antimalarial drugs. Emergence of artemisinin resistance could be devastating for individuals with malaria, unless timely detection by surveillance systems allows evaluation of new treatments and interventions to counter the spread of resistance.
Jean-Paul, Chretien +2 more
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A mathematical model for antimalarial drug resistance
Mathematical Medicine and Biology, 2010We formulate and analyze a mathematical model for malaria with treatment and the well-known three levels of resistance in humans. The model incorporates both sensitive and resistant strains of the parasites. Analytical results reveal that the model exhibits the phenomenon of backward bifurcation (co-existence of a stable disease-free equilibrium with a
Tchuenche, Jean M. +4 more
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Quinoline antimalarials: Mechanisms of action and resistance
International Journal for Parasitology, 1997The quinoline-containing antimalarial drugs, chloroquine, quinine and mefloquine, are a vital part of our chemotherapeutic armoury against malaria. These drugs are thought to act by interfering with the digestion of haemoglobin in the blood stages of the malaria life cycle. Chloroquine is a dibasic drug which diffuses down the pH gradient to accumulate
M, Foley, L, Tilley
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The antimalarial action of chloroquine and mechanisms of resistance
Annals of Tropical Medicine & Parasitology, 1987Specificite de stade de l'action de la chloroquine. Processus d'alimentation des parasites et action de la chloroquine-chloroquine et ferriprotoporphyrine X: chloroquine en tant qu'agent lysosomotrope. Resistance de P.
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Tackling the Problem of Antimalarial Resistance
2012The emergence and spread of resistance remain a burgeoning problem in the control and the management of malaria. Effort has been dedicated in discovering and developing new drugs; however, these efforts are hampered by the rapid selection of resistance. For instance, there is no single antimalarial in clinical use against which the parasite has not yet
John Okombo, Leah Mwai, Alexis Nzila
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Antimalarial resistance and health policies
Parasitology Today, 1993P L, Olliaro, P I, Trigg
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