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Traditional antimalarials and the development of novel antimalarial drugs
Journal of Ethnopharmacology, 2005Malaria continues to be a major cause of mortality and morbidity especially throughout the developing world. In the last 25 years or so a number of significant advances have been made that have the potential to make a major contribution to the control of this disease.
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Drug Discovery Today, 2005
Analysis of the trends in antimalarial research depicts a slow growth in launched products since 1995. However, 2002 saw the completion, after ten years, of the malarial genome project and an upsurge in products entering active development can be seen at the end of this period.
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Analysis of the trends in antimalarial research depicts a slow growth in launched products since 1995. However, 2002 saw the completion, after ten years, of the malarial genome project and an upsurge in products entering active development can be seen at the end of this period.
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2013
Hydroxychloroquine and chloroquine are antimalarial drugs used in the treatment of rheumatoid arthritis, systemic lupus erythematosus (SLE), antiphospholipid syndrome, skin diseases, and in the treatment of chronic Q fever. Hydroxychloroquine is the more widely used.
Pile, Kevin (R17082) +3 more
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Hydroxychloroquine and chloroquine are antimalarial drugs used in the treatment of rheumatoid arthritis, systemic lupus erythematosus (SLE), antiphospholipid syndrome, skin diseases, and in the treatment of chronic Q fever. Hydroxychloroquine is the more widely used.
Pile, Kevin (R17082) +3 more
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Arteether, a new antimalarial drug: synthesis and antimalarial properties
Journal of Medicinal Chemistry, 1988Arteether (6) has been prepared from dihydroquinghaosu (3) by etherification with ethanol in the presence of Lewis acid and separated from its chromatographically slower moving alpha-dihydroqinghaosu ethyl ether (7). The absolute stereochemistry at C-12 has been determined by 1H NMR data (J11,12, NOESY).
Arnold Brossi +8 more
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ChemInform Abstract: ANTIMALARIALS. 8. SYNTHESIS OF AMINO ETHERS AS CANDIDATE ANTIMALARIALS
Chemischer Informationsdienst, 1976AbstractAus den Isobutyrophenonen (I) entstehen die Bromverbindungen (II), die über die Epoxide (III) zu den Aminoketonen (IV) führen.
John Menke +3 more
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Antimalarials in the Treatment of Schistosomiasis
Current Pharmaceutical Design, 2012With just one drug used for individual patient management and community-based morbidity control, the treatment, control, and eventual elimination of schistosomiasis is vulnerable should resistance to praziquantel emerge and spread. The discovery and development of novel chemical entities that exhibit antischistosomal properties, and the repurposing of ...
Keiser, Jennifer, Utzinger, Jurg
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Antimalarial activity of cedronin
Journal of Ethnopharmacology, 1994Cedronin was isolated from Simaba cedron Planchon (Simaroubaceae), a species popularly believed in South America to have antimalarial properties. It was examined for in vitro and in vivo antimalarial activities and for cytotoxicity against KB cells. Experimental results showed that cedronin was active against chloroquine-sensitive and resistant strain,
Eric Deharo +5 more
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Drugs, 1987
Over the last decade, chloroquine-resistant falciparum malaria has spread to other areas from its original foci in Southeast Asia and South America. Additionally, new knowledge about the life-cycle of the malaria parasite, and about the pharmacokinetic properties of antimalarial drugs, has emerged.
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Over the last decade, chloroquine-resistant falciparum malaria has spread to other areas from its original foci in Southeast Asia and South America. Additionally, new knowledge about the life-cycle of the malaria parasite, and about the pharmacokinetic properties of antimalarial drugs, has emerged.
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Protoberberine alkaloids as antimalarials
Journal of Medicinal Chemistry, 1988The protoberberine alkaloids berberine (1), palmatine (2), jatrorrhizine (3), and several berberine derivatives (4-10) were tested for antimalarial activity in vitro against Plasmodium falciparum and in vivo against Plasmodium berghei. The berberine derivatives 4-10 were designed and synthesized to maximize structural diversity within a modest set of ...
Jonathan L. Vennerstrom +1 more
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Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials
2014This chapter provides details of studies that describe drug interactions in which antimalarial drugs affect the pharmacokinetics of various co-administered antimalarial drugs. These antimalarials include amodiaquine, artemether, artemisinin, artesunate, atovaquone, chloroquine, dapsone, mefloquine, primaquine, proguanil, pyrimethamine, quinidine ...
Tony K. L. Kiang +2 more
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