Results 181 to 190 of about 92,770 (362)

Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco

Plant Biotechnology Journal, EarlyView.
ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes, Omar Sandoval‐Ibáñez, Stéphanie Arrivault, David Rolo, F. Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka, Ralph Bock   +10 more
wiley   +1 more source

Associations Between Climate‐Sensitive Nutrients, Clinical Malaria, and Anaemia Among Young Children in Rural Burkina Faso: An Analysis of Baseline Data From a Cluster‐Randomised Controlled Trial

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective Malaria and anaemia are significant public health challenges among young children in Burkina Faso, with complex interactions between climate variability, food security, and nutrient deficiencies. This study aimed to identify the malariometric profile and nutrient patterns among young children and to determine the associations of ...
Adi Lukas Kurniawan, Maria Virginia Borga, Fanta Zerbo, Carol Akinyi Abidha, Anais Gonnet, Raissa Sorgho, Boubacar Coulibaly, Ali Sié, Ina Danquah   +8 more
wiley   +1 more source

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Integration of a WASH Component in the Standard National Protocol for Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months in Northern Senegal—A Costing Study

Maternal &Child Nutrition, Volume 22, Issue 1, March 2026.
This study provides the first cost analysis of integrating a WASH kit into outpatient SAM treatment in Senegal, highlighting key cost drivers and potential efficiencies for scale‐up. Findings offer practical insights for planning and budgeting integrated WASH‐nutrition interventions in similar settings.
Bibata Wassonguema, Maily Lê‐Lacanette, Laura Braun, Matar Ba, Françoise Siroma, Albert Emile Cabo, Antonio Vargas Brizuela, Moustapha Seye, Jean Lapègue, Alexandre Devort, Oliver Cumming, Dieynaba S. N'Diaye   +11 more
wiley   +1 more source

Certification and Credibility: Do Seed Certification Systems in Uganda Help Signal Quality to Farmers?

Journal of Agricultural Economics, Volume 77, Issue 1, Page 48-56, February 2026.
ABSTRACT The value of purchased seed is a product of its underlying genetic information. However, farmers purchasing seed face a classic information asymmetry problem, as varietal identity is not directly observable. In this article we investigate the effectiveness of two certification systems in addressing this issue in the context of Uganda: the ...
Nicholas Tyack, Martina Bozzola, Tim Swanson, Helena Ting   +3 more
wiley   +1 more source

Antimalarials inhibit hematin crystallization by unique drug–surface site interactions

Proceedings of the National Academy of Sciences of the United States of America, 2017
Katy N. Olafson, Tam Q. Nguyen, J. Rimer, P. Vekilov   +3 more
semanticscholar   +1 more source

Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack

New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.
Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos, The Dan Pham, Thibaut Perez, Myriam Ben Amar, Claire Corratgé‐Faillie, François Barbier, Benoit Lacombe   +6 more
wiley   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials. [PDF]

PLoS Pathog
Tsebriy O, Khomiak A, Miguel-Blanco C, Sparkes PC, Gioli M, Santelli M, Whitley E, Gamo FJ, Delves MJ.   +8 more
europepmc   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source