Results 171 to 180 of about 28,999 (273)

Synthesis of Chalcone‐Sulfonamide Hybrids as Antibacterial, Antioxidant, and Anti‐Inflammatory Agents With Comprehensive In Silico and ADMET Profiling

ChemistryOpen, Volume 15, Issue 9, September 2026.
Eight chalcone‐sulfonamide hybrids (12a–h) are synthesized via Claisen–Schmidt condensation and evaluated for antibacterial, antioxidant, and anti‐inflammatory activity. The compounds show potent radical scavenging, strong protein‐denaturation inhibition surpassing diclofenac, and favorable docking against DHPS, myeloperoxidase, COX‐2, and ...
Mlis Belete, Endale Mulugeta, Daniel Rentsch, Muhdin Aliye, Kebede Shenkutie, Yadessa Melaku   +5 more
wiley   +1 more source

Guideline-concordant care and outcomes for pediatric malaria cases: descriptive evidence from pharmacy-based fever management in Kenya. [PDF]

Malar J
Dieci M, Nekesa C, Kayaro NI, Vernon J, Graetz I, Winskell K, Cummings JR.   +6 more
europepmc   +1 more source

Pediatric Use of Off‐Label Medicines and Nonevidence‐Based Supplements for COVID‐19: Findings From the 2015 Pelotas Birth Cohort Study (Brazil)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Purpose Pediatric off‐label medicine use increased during the COVID‐19 pandemic, exposing children to nonevidence‐based treatments. We described the use of nonevidence‐based COVID‐19 medicines and supplements among children from the 2015 Pelotas Birth Cohort, according to sociodemographic and health‐related characteristics.
Andréa Dâmaso Bertoldi, Fernando Silva Guimarães, Alexandra Crispim Boing, Marysabel Pinto Telis Silveira, Pedro Curi Hallal, Mariângela Freitas da Silveira   +5 more
wiley   +1 more source

Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials. [PDF]

ACS Infect Dis
Maluf SEC, Mendes GR, Moura IMR, de Souza GE, Valdes TA, Bonatto V, Oliveira GS, Aguiar ACC, Gazarini ML, Puhl AC, Monakhova N, Lepioshkin A, Makarov V, Lane TR, Raman R, Campolina GAS, Barbosa CS, Ferreira ADS, Teles CBG, Pereira DB, Barros RRM, Benavente ED, Ekins S, Guido RVC.   +23 more
europepmc   +1 more source

Substandard and Falsified Medicines, Regulatory Capacity and Public Health: A Narrative Review With a Focus on Africa

Public Health Challenges, Volume 5, Issue 3, September 2026.
Weak medicines regulation in Africa enables the circulation of substandard and falsified medicines, undermining treatment outcomes, accelerating antimicrobial resistance and eroding public trust. This narrative review synthesised 38 studies from 2000 to 2025, highlighting regulatory gaps, public health harms and regional disparities.
Ahmed Vandy, Nancy Oluwakemi Samai, Onome Thomas Abiri, Michael Lahai, Fawzi Thomas, Tamba Buffa, Sheku Mansaray, Alvin Turay, Augustus Osborne   +8 more
wiley   +1 more source

Ligand decorated nanostructure carrier systems for targeted delivery of antimalarials. [PDF]

Discov Nano
Singh K, Ranjha R, Malla WA, Sharma P, Mohan M, Das J, Singh H, Bharti PK, Anvikar AR.   +8 more
europepmc   +1 more source

High-Throughput Screening of Antimalarials via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

, 2007
The counterfeiting of pharmaceuticals, especially antimalarials, is a well-recognized and growing public health problem. There have been an alarming number of reports of counterfeit antimalarials throughout the world and insufficient regulations and ...
Johnson, Kristin R.
core  

A Review on Green Synthetic Approaches in the Development of Quinoline Analogues

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This review highlights recent advances in environmentally friendly approaches, including metal‐free systems, solvent‐free approaches, microwave, and ultrasonic‐assisted techniques, organo‐ and biocatalysis, ionic liquids, nanoparticle catalysis, electrochemical, and photocatalytic strategies for the synthesis of quinoline scaffolds.
Demis Zelelew, Ajay Bissessur, Parvesh Singh, Hogantharanni Govender   +3 more
wiley   +1 more source

Indole-based hybrids target both asexual parasites and gametocytes of <i>Plasmodium falciparum</i> and synergize with lumefantrine. [PDF]

Antimicrob Agents Chemother
Mohanty A, Nakabashi M, Dias BKM, Maiolini P, Delgado JAC, Quaglio KdS, Paixão MW, Garcia CRS.   +7 more
europepmc   +1 more source

Response Surface Method‐Optimized Microwave‐Assisted Extraction and LC–MS/MS Profiling of Bioactive Compounds Wild Edible Arisaema schimperianum Tuber

SEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.
Response surface optimization identified 60% microwave power and 40 s as a balanced condition for recovering bioactive compounds from Arisaema schimperianum tuber. LC–MS/MS profiling revealed diverse metabolites, while freeze‐drying best preserved thermolabile compounds, highlighting an effective strategy for maximizing extraction efficiency and ...
Gezahegn Abawa Zeleke, Shimelis Admassu Emire, Maryna De Wit   +2 more
wiley   +1 more source