Results 1 to 10 of about 3,455 (191)

Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography

Journal of Ophthalmology, 2016
Purpose. To evaluate the effect of hydroxychloroquine on retinal pigment epithelium- (RPE-) Bruch’s membrane complex, photoreceptor outer segment, and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses using spectral-domain optical coherence
Hasim Uslu, Bulent Gurler, Aydin Yildirim, Mehmet Gurkan Tatar, Feride Aylin Kantarcı, Hasan Goker, Hatice Seval Pehlevan, Hatice Nur Colak   +7 more
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Risk of QT prolongation through drug interactions between hydroxychloroquine and concomitant drugs prescribed in real world practice

Scientific Reports, 2021
Hydroxychloroquine has recently received attention as a treatment for COVID-19. However, it may prolong the QTc interval. Furthermore, when hydroxychloroquine is administered concomitantly with other drugs, it can exacerbate the risk of QT prolongation ...
Byung Jin Choi, Yeryung Koo, Tae Young Kim, Wou Young Chung, Yun Jung Jung, Ji Eun Park, Hong-Seok Lim, Bumhee Park, Dukyong Yoon   +8 more
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Hydroxychloroquine improves manifestation of PE rats under oxidative stress by regulating the PI3K/AKT/mTOR signaling pathway to inhibit autophagy

Scientific Reports
Preeclampsia is currently thought to be characterized by placental oxidative stress damage. Hydroxychloroquine is known to have antioxidant effects, but there are fewer studies on hydroxychloroquine in oxidative stress in preeclampsia. The main objective
Wu Han, Xu Jing, Chu XiaoYan, Huang Wen Wen, Fan Xia, Ren Qin Qin, Wang Ying, Li Xia, Wang Man, Wang Xiu   +9 more
doaj   +1 more source

Hydroxychloroquine as a primary prophylactic agent against SARS-CoV-2 infection: A cohort study

International Journal of Infectious Diseases, 2021
Objective: Hydroxychloroquine has been proposed as a primary prophylactic agent against coronavirus disease 2019 (COVID-19). This study aimed to investigate if patients treated with hydroxychloroquine for a non-COVID-19 indication had a lower risk of ...
Peter Kamstrup, Pradeesh Sivapalan, Josefin Eklöf, Nils Hoyer, Charlotte Suppli Ulrik, Lars Pedersen, Therese S. Lapperre, Zitta Barrella Harboe, Uffe Bodtger, Rasmus Dahlin Bojesen, Kjell E.J. Håkansson, Casper Tidemandsen, Karin Armbruster, Andrea Browatzki, Howraman Meteran, Christian Niels Meyer, Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Jens D. Lundgren, Tor Biering-Sørensen, Jens-Ulrik Jensen   +20 more
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Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates

Frontiers in Bioscience-Landmark, 2021
Background: Despite the fact that the clinical efficacy of hydroxychloroquine is still controversial, it has been demonstrated in vitro to control SARS-CoV-2 multiplication on Vero E6 cells.
Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Anthony Levasseur, Bernard La Scola   +10 more
doaj   +1 more source

Hydroxychloroquine shortened hospital stay and reduced intensive care unit admissions in hospitalized COVID-19 patients

Journal of Infection in Developing Countries, 2022
Introduction: Effectiveness of hydroxychloroquine against SARS-CoV-2 has been highly controversial. In our research, we aimed to investigate the effects of hydroxychloroquine on disease outcomes in hospitalized patients with COVID-19.
Ahmet Omma, Abdulsamet Erden, Hakan Apaydin, Meryem Aslan, Hüseyin Çamlı, Enes Seyda Şahiner, Serdar Can Güven, Berkan Armağan, Selma Karaahmetoğlu, Ihsan Ates, Orhan Kucuksahin   +10 more
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COVID-19 Pneumonia in Patients on Chronic Hydroxychloroquine Therapy: Three Cases of COVID-19 Pneumonia

Case Reports in Infectious Diseases, 2020
Hydroxychloroquine has gained popularity as a potential preventative and treatment of COVID-19 pneumonia due to its in vitro activity against the virus.
Awan K. Rahman, Adam G. Purdy, Peter T. Ender   +2 more
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Effect of hydroxychloroquine and azithromycin combination use in COVID-19 patients – An umbrella review

Indian Journal of Community Medicine
Background: Hydroxychloroquine and Azithromycin combination was used rampantly in management of COVID-19 patients in different countries. Present review was conducted to evaluate the efficacy of Hydroxychloroquine and Azithromycin combination compared to
Kaushik Nag, Kaushik Tripura, Anjan Datta, Nabarun Karmakar, Manvi Singh, Meenu Singh, Kusum Singal, Pranita Pradhan   +7 more
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Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining Azithromycin?

Frontiers in Immunology, 2020
Recent small-scale clinical trials have shown promising results in the use of hydroxychloroquine, an FDA approved anti-malaria drug, for the treatment of COVID-19.
Chunfeng Li, Genhong Cheng
doaj   +1 more source

Examination of patient characteristics and hydroxychloroquine use based on the US Food and Drug Administration’s recommendation: a cross-sectional analysis in New York

BMJ Open, 2021
Objective To describe the pattern of hydroxychloroquine use and examine the association between hydroxychloroquine use and clinical outcomes arising from changes in the US Food and Drug Administration (FDA)’s recommendation during the coronavirus disease
, Sonali Narain, Charlotte Kvasnovsky, Joseph Conigliaro, Martin Lesser, Eun Ji Kim, Kevin Coppa, Jamie S Hirsch, Sara Abrahams, Jennifer Johnson, Karina W Davidson, Stuart L Cohen, Stephen C Machnicki, Alex Makhnevich, Prashant Malhotra, Lyndonna Marrast, Ramanak Mitra, Ernesto P Molmenti, M Wasif Saif, Sanjaya Satapathy, Shalin Shah   +20 more
doaj   +1 more source