Results 21 to 30 of about 88,199 (267)

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial [PDF]

, 2016
Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA).
Chen, Li-Na, Deng, Xue-Rong, Fang, Yong-Fei, Gu, Fei, Hao, Yan-Jie, He, Jing, Keystone, Edward, Li, Ru, Li, Xing-Fu, Li, Zhan-Guo, Liu, Hua-Xiang, Liu, Xiang-Yuan, Liu, Yi, McInnes, Iain B., Su, Yin, Sun, Ling-Yun, Xue, Yu, Zhang, Zhuo-Li, Zhao, Cheng, Zhao, Jin-Xia, Zhao, Yi, Zhou, Wei, Zhu, Ping, Zou, He-Jian, Zou, Qing-Hua   +24 more
core   +3 more sources

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]

, 2019
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton, A Kuma, AS Corbin, B Ronan, B Zhang, B Zhang, BJ Druker, C Bellodi, D Mahalingam, DJ Klionsky, DT Vogl, E Weisberg, F Liu, G Karsli-Uzunbas, JD Mancias, JY Guo, JY Guo, M Karvela, M Komatsu, M Mortensen, M Schemionek, MR Rosenfeld, MR Warr, MT Rosenfeldt, N Mizushima, P Rousselot, Q McAfee, R Bago, R Rangwala, R Rangwala, S Brenner, S Kimura, S Koschmieder, SM Graham, T Holyoake, TL Holyoake, TL Holyoake, TT Ho, V Kirkin, VW Rebecca, WE Dowdle, XH Ma, Z Tothova   +42 more
core   +2 more sources

Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro.

PLoS ONE, 2022
Preeclampsia is a multi-system disease that can have severe, even fatal implications for the mother and fetus. Abnormal placentation can lead to ischaemic tissue injury and placental inflammation.
Elif Kadife, Natalie Hannan, Alesia Harper, Natalie Binder, Sally Beard, Fiona C Brownfoot   +5 more
doaj   +2 more sources

The effect of hydroxychloroquine on glucose control and insulin resistance in the prediabetes condition

Advanced Biomedical Research, 2016
Background: Hydroxychloroquine can improve most underlying coronary risk factors; however, there are a few studies on the effects of hydroxychloroquine on blood glucose and insulin resistance.
Fahimeh Sheikhbahaie, Masoud Amini, Mojgan Gharipour, Ashraf Aminoroaya, Nader Taheri   +4 more
doaj   +1 more source

How different is the status of depression and anxiety in patients with rheumatoid arthritis receiving methotrexate with sulfasalazine or hydroxychloroquine?

Russian Open Medical Journal, 2023
Background — Depression and anxiety are among the most common clinical manifestations in patients with rheumatoid arthritis (RA). Sulfasalazine and hydroxychloroquine are important medications used to treat these patients.
Mansour Babaei, Mehdi Dorparvar, Behnaz Yousef Ghahari, Behzad Heidari, Hemmat Gholinia, Sussan Moudi   +5 more
doaj   +1 more source

Association of hydroxychloroquine and cardiac arrhythmia in patients with systemic lupus erythematosus: A population-based case control study.

PLoS ONE, 2021
ObjectivesHydroxychloroquine is widely used to treat certain viral and rheumatic diseases including systemic lupus erythematosus. Cardiac arrhythmia is an important safety issue with hydroxychloroquine.
Chien-Hsien Lo, Yu-Hsun Wang, Chin-Feng Tsai, Kuei-Chuan Chan, Li-Ching Li, Tse-Hsien Lo, James Cheng-Chung Wei, Chun-Hung Su   +7 more
doaj   +1 more source

Data on hydroxychloroquine interference with urine laboratory testing

Data in Brief, 2019
Hydroxychloroquine is a medication used to treat rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune disorders. Previous studies have shown that hydroxychloroquine and the structurally related drug chloroquine have the potential to ...
Jennie M. Kingery, Joshua B. Radke, Jon Maakestad, Matthew D. Krasowski   +3 more
doaj   +1 more source

Diagnostic pitfalls and laboratory test interference after hydroxychloroquine intoxication: A case report

Toxicology Reports, 2019
Hydroxychloroquine is a medication used to treat autoimmune conditions. Overdoses of hydroxychloroquine are uncommon, with most recommendations on monitoring drawing from experience with more common overdoses of the related drug chloroquine. We present a
Joshua B. Radke, Jennie M. Kingery, Jon Maakestad, Matthew D. Krasowski   +3 more
doaj   +1 more source

Use of the painDETECT tool in rheumatoid arthritis suggests neuropathic and sensitization components in pain reporting. [PDF]

, 2014
Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted toward synovial joints. Inhibition of proinflammatory networks by disease-modifying antirheumatic drugs, eg, methotrexate and biologic therapies,
Ahmed, S, Harrison, A, Magan, T, Sofat, N, Vargas, M   +4 more
core   +2 more sources

Effect of hydroxychloroquine on glycemic variability in type 2 diabetes patients uncontrolled on glimepiride and metformin therapy

Indian Journal of Endocrinology and Metabolism, 2022
Background and Aims: No study to date has assessed the effect of hydroxychloroquine on various parameters of glycaemic variability. To assess the effect of hydroxychloroquine on glycaemic variability in type 2 diabetes patients uncontrolled on ...
Rajesh Rajput, Suyasha Saini, Siddhant Rajput, Parankush Upadhyay   +3 more
doaj   +1 more source