Results 151 to 160 of about 26,961 (258)

Guideline-concordant care and outcomes for pediatric malaria cases: descriptive evidence from pharmacy-based fever management in Kenya. [PDF]

Malar J
Dieci M, Nekesa C, Kayaro NI, Vernon J, Graetz I, Winskell K, Cummings JR.   +6 more
europepmc   +1 more source

Hybrid Aminoferrocenes With Nitrate Esters for In Situ Peroxynitrite Generation: Complex Interplay Between Redox Chemistry, NO‐Donor Reactivity, and Aminoferrocene Activation Influences In Vitro Anticancer Activity

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Aminoferrocene‐based prodrugs represent a promising class of redox‐active anticancer agents that can be selectively activated in oxidative cellular environments. However, activation of these systems typically relies on reactive oxygen species (ROS) and is therefore inefficient in intracellular compartments with low ROS levels, such as the cytoplasm. In
Hülya Gizem Özkan, Roman Selin, Paula Holst, Rainer Tietze, Christoph Alexiou, Andriy Mokhir   +5 more
wiley   +1 more source

Ligand decorated nanostructure carrier systems for targeted delivery of antimalarials. [PDF]

Discov Nano
Singh K, Ranjha R, Malla WA, Sharma P, Mohan M, Das J, Singh H, Bharti PK, Anvikar AR.   +8 more
europepmc   +1 more source

Metal–Drug Complexes as Long‐Release Application for Antimalarial PfFNT‐Inhibitors

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
P. falciparum formate‐nitrite transporter (PfFNT) inhibitors have emerged as a novel antimalarial class with potent in vivo and liver‐stage activity. Low‐solubility metal–inhibitor complexes were prepared as potential long‐acting injectables.
Finn Tiedjens, Björn Henke, Ulrich Girreser, Regina Scherließ, Eric Beitz   +4 more
wiley   +1 more source

Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood. [PDF]

Clin Infect Dis
Saito M, Gilder ME, Carrara VI, Archusuksan L, Eh H, Eh N, Ner M, Win AK, Niwetphongprai L, Koesukwiwat U, Tarning J, White NJ, Nosten F, McGready R.   +13 more
europepmc   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Clinical spectrum and management outcomes of acute febrile illness Among children attending health facilities in northwestern Tanzania, 2020-2021. [PDF]

Front Pediatr
Kayange NM, Malande OO, Gehring S, Scialabba S, Groendahl B, Koliopoulos P, Mshana SE.   +6 more
europepmc   +1 more source

Enantiospecific Acid‐Catalysed Hydroperoxidation of Scalemic Tertiary Benzylic Alcohols Facilitating a Concise Asymmetric Synthesis of Yingzhaosu C

European Journal of Organic Chemistry, Volume 29, Issue 26, 13 July 2026.
Asymmetric synthesis of antimalarial yingzhaosu C was achieved in 4–5 steps by asymmetric Grignard synthesis of (R)‐gossonorol followed by novel enantiospecific hydroperoxidation. We report a concise asymmetric synthesis of antimalarial yingzhaosu C in 59% ee.
Saranna E. Kavanagh, Claudio Monasterolo, Declan G. Gilheany   +2 more
wiley   +1 more source

Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials. [PDF]

ACS Infect Dis
Maluf SEC, Mendes GR, Moura IMR, de Souza GE, Valdes TA, Bonatto V, Oliveira GS, Aguiar ACC, Gazarini ML, Puhl AC, Monakhova N, Lepioshkin A, Makarov V, Lane TR, Raman R, Campolina GAS, Barbosa CS, Ferreira ADS, Teles CBG, Pereira DB, Barros RRM, Benavente ED, Ekins S, Guido RVC.   +23 more
europepmc   +1 more source

Positive tests are all alike, every negative test is negative in its own way: lack of confidence in negative malaria rapid diagnostic tests in the Democratic Republic of the Congo. [PDF]

Malar J
Sugg KN, Mpata FW, Humes MD, Aliango Marachto D, Rajan R, Winch PJ.   +5 more
europepmc   +1 more source