Results 131 to 140 of about 26,961 (258)

Evolution‐Inspired Engineering of Diterpene Biosynthesis via Chloroplast Genome Modification

Plant Biotechnology Journal, EarlyView.
ABSTRACT Terpenes constitute the largest and most structurally diverse class of plant secondary metabolites, with critical roles in plant‐environment interactions and broad industrial applications. Although nuclear genome engineering of terpene pathways has been extensively explored, chloroplast genome engineering remains largely undeveloped, with all ...
Alessandro Occhialini, Xinlu Chen, Samantha A. Miller, Mohammad Majdi, Ivette A. Fuentes Quispe, Gabriella King, Feng Chen   +6 more
wiley   +1 more source

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, EarlyView.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Nationwide Temporal Trends in Adverse Pregnancy Outcomes and Treatments in Systemic Lupus Erythematosus Pregnancy Over Two Decades in Sweden

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1700-1709, August 2026.
Objective This nationwide descriptive study examined temporal trends in adverse pregnancy outcomes (APOs) and treatments in systemic lupus erythematosus (SLE) pregnancies in Sweden over 2003 to 2022. Methods Using nationwide Swedish registers, we identified 1,417 pregnancies of women with prevalent SLE and delivery dates in 2003 to 2022 and matched ...
Ngoc V. Nguyen, Anna Sandström, Annica Dominicus, Elisabet Svenungsson, Karin Hellgren, Julia F. Simard, Elizabeth V. Arkema   +6 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

The use of antimalarial drugs.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
A general review is given of the antimalarial drugs currently available and in common use, with special reference to those found to be of most benefit in Southern Africa.S. Afr. Med. J., 48, 1314 (1974)
openaire   +3 more sources

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Ultra-performance liquid chromatography coupled with mass spectrometry profiling and evaluation of in vitro anti-Plasmodium falciparum activity of extracts from a Congolese Ancistrocladus species

Discover Chemistry
Malaria remains one of the leading causes of death globally, particularly in developing countries. This study aimed to investigate the antimalarial activity and UPLC-MS profiling of crude extracts from a new Ancistrocladus species collected in Banalia ...
Justin Bazibuhe Safari, Félicien Mushagalusa Kasali, Séverin Muyisa Kavatsurwa   +2 more
doaj   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source