Results 131 to 140 of about 63,797 (281)

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source

Guideline-concordant care and outcomes for pediatric malaria cases: descriptive evidence from pharmacy-based fever management in Kenya. [PDF]

Malar J
Dieci M, Nekesa C, Kayaro NI, Vernon J, Graetz I, Winskell K, Cummings JR.   +6 more
europepmc   +1 more source

The use of antimalarial drugs.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
A general review is given of the antimalarial drugs currently available and in common use, with special reference to those found to be of most benefit in Southern Africa.S. Afr. Med. J., 48, 1314 (1974)
openaire   +3 more sources

Antimalarials inhibit hematin crystallization by unique drug–surface site interactions

Proceedings of the National Academy of Sciences of the United States of America, 2017
Katy N. Olafson, Tam Q. Nguyen, J. Rimer, P. Vekilov   +3 more
semanticscholar   +1 more source

Synthesis, Characterization, and Anti‐Plasmodium falciparum Activity of a New Copper(II) Complex Containing 2‐(Tert‐Butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
The graphical abstract illustrates the formation of a Cu(II) complex from azole‐based ligand, highlighting metal–ligand synergy. The resulting coordination compound acts as a bioactive entity against Plasmodium, where metal coordination enhances antiparasitic activity, outperforming the free ligand and demonstrating its potential as an antimalarial ...
Alexander Patiño‐Cubides, María Camila Velasco‐Pareja, Mario A. Macías, María F. Yasnot‐Acosta, Ana Rodriguez, Augusto Valderrama‐Aguirre, John J. Hurtado   +6 more
wiley   +1 more source

Ligand decorated nanostructure carrier systems for targeted delivery of antimalarials. [PDF]

Discov Nano
Singh K, Ranjha R, Malla WA, Sharma P, Mohan M, Das J, Singh H, Bharti PK, Anvikar AR.   +8 more
europepmc   +1 more source

Total Synthesis and Antimalarial Studies of Caelestines A–C

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith, Aaron M. Lock, Vicky M. Avery, Rohan A. Davis   +3 more
wiley   +1 more source

Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood. [PDF]

Clin Infect Dis
Saito M, Gilder ME, Carrara VI, Archusuksan L, Eh H, Eh N, Ner M, Win AK, Niwetphongprai L, Koesukwiwat U, Tarning J, White NJ, Nosten F, McGready R.   +13 more
europepmc   +1 more source