Results 111 to 120 of about 26,961 (258)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Identification of a New Chemical Class of Antimalarials [PDF]

, 2017
The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials.
Heidmann, Bibia, Welford, Richard, Bozdech, Zbynek, Papastogiannidis, Petros, Fischli, Christoph, Voss, Till, Boss, Christoph, Wittlin, Sergio, Corminboeuf, Olivier, Kamber, Jolanda, Binkert, Christoph, Delahaye, Stephane, Brunner, Ralf, Brun, Reto, Kaiser, Marcel, Siegrist, Romain, Meyer, Solange, Aissaoui, Hamed   +17 more
core  

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Tambjamines as Fast-Acting Multistage Antimalarials. [PDF]

Well-tolerated and novel antimalarials that can combat multiple stages of the parasite life cycle are desirable but challenging to discover and develop. Herein, we report results for natural product-inspired novel tambjamine antimalarials.
Madejczyk, Michael, Madejczyk, Michael S., Cooper, Roland A, Peyton, David H., Matthews, Holly, Reynolds, Kevin A, Reynolds, Kevin, Lee, Patricia, Rasmussen, Stephanie, Tumwebaze, Patrick, Orjuela-Sanchez, Pamela, Cooper, Roland, Winzeler, Elizabeth A., Kelly, Jane X., Caridha, Diana, Jin, Xiannu, Baum, Jake, Ceja, Frida G, Evans, Martin, Tumwebaze, Patrick K, Rosenthal, Philip, Kirby, Robert, Dodean, Rozalia A., Burrows, Jeremy N., Kancharla, Papireddy, Pybus, Brandon, Burrows, Jeremy N, Winzeler, Elizabeth, Dennis, William, Kelly, Jane X, Dennis, William E., Rosenthal, Philip J., Kumar, Amrendra, Reynolds, Kevin A., Dinh, Hieu T, Dinh, Hieu, Kirby, Robert W., Dodean, Rozalia, Pybus, Brandon S., Vuong, Chau, Lee, Patricia J., Rasmussen, Stephanie A, Li, Yuexin, Blount, Cameron, Pybus, Brandon S, Chetree, Ravi, Winzeler, Elizabeth A, Kirby, Robert W, Rasmussen, Stephanie A., Cooper, Roland A., Ceja, Frida G., Dodean, Rozalia A, Sousa, Jason, Duffy, James, Burrows, Jeremy, Delves, Michael J., Ceja, Frida, Black, Chad, Tumwebaze, Patrick K., Peyton, David, Rosenthal, Philip J, Meister, Stephan, Martin, Monica, Peyton, David H, Kelly, Jane, Nolan, Christina, Dennis, William E, Delves, Michael J, Rottmann, Matthias, Pannone, Kristina, Dinh, Hieu T., Roth, Alison, Delves, Michael, Madejczyk, Michael S, Nadeau, Robert, Leed, Susan, DeLuca, Jesse, Lee, Patricia J   +77 more
core   +1 more source

A link between poor quality antimalarials and malaria drug resistance? [PDF]

, 2016
Malaria remains a major public health problem for most of the world. The tragedy remains that many more malaria patients would survive if they had timely access to good quality, affordable and efficacious medicines.
Guerin, P, Newton, Paul, Guerin, Philippe, Guerin, Philippe J., Caillet, C, Caillet, Céline, Newton, P   +6 more
core   +2 more sources

Discoid Lupus Erythematosus in Genital Skin: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation.
Ala' Abu‐Dayeh, Daniel Miller, Alessio Giubellino   +2 more
wiley   +1 more source

Antimaláricos e Ototoxicidade Antimalarials and Ototoxicity

Revista Brasileira de Reumatologia, 2004
Os antimaláricos, como o difosfato de cloroquina, têm sido usados amplamente no tratamento não só da malária, mas também de doenças reumatológicas como a síndrome de Sjögren (SS), artrite reumatóide (AR) e lúpus eritematoso sistêmico (LES).
Marcelo Cardoso Figueiredo, Ciríaco Cristóvão C. T. Atherino, Clarice Viana Monteiro, Roger Abramino Levy   +3 more
doaj   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

P. vivax life cycle and sites of action for different antimalarials. [PDF]

, 2013
P. vivax life cycle and sites of action for different antimalarials.
Quique Bassat (89288)
core   +1 more source

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

Frontiers in Chemistry
Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in
Romina E. Avanzo, Guadalupe García Liñares, Noris Rodríguez, Angel H. Romero   +3 more
doaj   +1 more source