Results 101 to 110 of about 28,999 (273)

Human pharmacokinetics of antimalarials tested in this study.

, 2013
Human pharmacokinetics of antimalarials tested in this study.
Ingmar Peitz (503779), R. Kiplin Guy (160393), Margaret A. Phillips (270292), Richard K. Haynes (450226), Jonathan L. Vennerstrom (503780), Kelly Chibale (503778), Rob Hooft van Huijsduijnen (151694), Gerhard Kelter (78338), Timothy N. C. Wells (422572), Yongyuth Yuthavong (269209)   +9 more
core   +1 more source

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

JSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune, Amare Bitew Mekonnen, Getahun Yemata   +2 more
wiley   +1 more source

Antimalarials—Are They Safe to Use in Children? [PDF]

, 1983
From 963 to the present, many reviews of antimalarials for use in dermatology have mentioned the special sensitivity of children to these drugs. Fatal reactions have been limited to accidental or intentional overdosage and two instances of IM injection ...
Rasmussen, James E., James E. Rasmussen
core   +1 more source

Paediatric Melanonychia: Diagnosis and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Longitudinal melanonychia (LM) in children presents unique diagnostic and management challenges that cannot be adequately addressed by applying adult‐based criteria. Unlike in adults, there are no validated clinical, dermoscopic or histopathologic criteria for predicting nail unit melanoma in the paediatric population.
Angela J. Jiang, Erika Koh, Je‐Ho Mun, Dong‐Youn Lee, Matilde Iorizzo, Adam I. Rubin   +5 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Availability and Prices of Antimalarials and Staffing Levels in Health Facilities in Embu County, Kenya [PDF]

, 2019
Effective treatment of malaria relies on the availability of quality medicines while pricing is a major determinant of affordability. In addition, adequate numbers of competent staff of different cadres is essential for a well-functioning health system ...
Kibwage, I., Ndwigah, S., Stergachis, A., Mugo, H., Abuga, K.   +4 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Antimalarials and the fight against malaria in Brazil

, 2009
Luiz MA Carmargo1, Saulo de Oliveira2, Sergio Basano3, Célia RS Garcia21ICBV-USP, Monte Negro, Rondônia, Brasil; 2Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, SP, Brazil ...
Célia RS Garcia, Luiz MA Carmargo, Sergio Basano, Saulo de Oliveira   +3 more
core  

Attempts to Prepare Antimalarials. Part IV. Derivatives of Cotarnine.

, 1933
Attempts to Prepare Antimalarials. Part IV.
GURCHARAN SINGH AHLUWALIA, JNANENDRA NATH RÂY, KANSHI NATH KAUL   +2 more
core   +1 more source

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. [PDF]

, 2009
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic procedures and characterized by low potential for developing resistance are urgently needed.
E. Novellino, Gemma, S, Gemma S., Fiorini, I., Brun R., Basilico, Nicoletta, Kukreja, Gagan, Bernetti, M., Basilico, N., Nacci, V, Coletta, M, S. Parapini, Fiorini, Isabella, Butini, S., Coccone, Salvatore Sanna, Brun, R, Bernetti, M, Coccone S. S., Basilico N., M. Rottmann, S. Marini, Coletta, Massimiliano, Taramelli, Donatella, S. Caccia, Persico, Marco, Sanna Coccone, Salvatore, C. Fattorusso, Persico, M, Brun, R., Novellino, E, Marini, Stefano, Kellere Maerki, S., M. Coletta, Keller-Maerki S.,, Campiani, G, Parapini, S, Joshi, BP, Parapini S., Guiso, G, Coletta M., Marini, S, Rottmann M., Nacci, V., D. Taramelli, Taramelli, D, Marini S., N. Basilico, Yardley, V., M. Persico, Parapini, S., Gemma, S., Kukreja G., Fattorusso, C., Caccia, S., Bernetti M., Novellino, Ettore, Caccia, S, Caccia S., Taramelli, D., S. Croft, Coccone, S, Keller-Maerki, S, S. S. Coccone, G. Guiso, Joshi, Bhupendra P, Persico, M., Kukreja, G., Butini, Stefania, Keller-Maerki, Sonja, G. Campiani, Novellino, E., Croft, S, Yardley, V, Joshi Bhupendra P., Taramelli D., Nacci, Vito, Coccone, SS, G. Kurkreja, Rottmann, M., Coletta, M., S. Keller Maerki, Campiani, G., Basilico, N, R. Brun, Joshi, B, Bernetti, Matteo, Guiso G., M. Bernetti, Guiso, G., B. P. Joshi, Croft, S., Rottmann, M, Croft S., Joshi, B. P., Nacci V., Fiorini, I, S. Gemma, Yardley V., Butini, S, Fattorusso, Caterina, Butini S., I. Fiorini, Keller Maerki S., V. Nacci, S. Butini, V. Yardley, Keller Maerki, S, Parapini, Silvia, Marini, S., Gemma, Sandra, Kukreja, G, Guiso, Giovanna, Caccia, Silvio, Fattorusso, C, Rottmann, Matthias, Brun, Reto, Campiani, Giuseppe, Yardley, Vanessa, Coccone, S. S., Campiani G., Fiorini I., Croft, Simon   +121 more
core   +1 more source