Results 101 to 110 of about 26,961 (258)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives [PDF]

, 2014
Despite the efforts in controlling the parasite and infection, and the significant progress achieved in recent years in its treatment, malaria is still prevalent in many regions and out of control in others.
Araki, Koiti, Garcia, Celia Regina da Silva, Deda, Daiana Kotra, Budu, Alexandre [UNIFESP], Cruz, Laura Nogueira   +4 more
core   +1 more source

Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

Memorias do Instituto Oswaldo Cruz, 2014
In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned ...
Fernando Fonseca Val, Vanderson Souza Sampaio, Maria Belén Cassera, Raquel Tapajós Andrade, Pedro Luiz Tauil, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda   +6 more
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria. [PDF]

, 2009
BACKGROUND: There is little existing knowledge about actual quality of drugs provided by different providers in Nigeria and in many sub-Saharan African countries.
Hanson, Kara, Dike Nkem, Paul Okonkwo, Shu Elvis, Harparkash Kaur, Onwujekwe, Obinna, Uzochukwu, Benjamin, Nkem Dike, Hanson Kara, Okoye Viola, Obinna Onwujekwe, Uzochukwu Benjamin, Viola Okoye, Kaur, Harparkash, Okoye, Viola, Benjamin Uzochukwu, Kara Hanson, Shu, Elvis, Elvis Shu, Kaur Harparkash, Dike, Nkem, Okonkwo, Paul, Onwujekwe Obinna, Okonkwo Paul   +23 more
core   +1 more source

New approaches in antimalarial drug discovery and development: a review

Memorias do Instituto Oswaldo Cruz, 2012
Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs.
Anna Caroline C Aguiar, Eliana MM da Rocha, Nicolli B de Souza, Tanos CC França, Antoniana U Krettli   +4 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, EarlyView.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Knowledge and practices relating to malaria in a semi-urban area of Cameroon: choices and sources of antimalarials, self-treatment and resistance

The Pan African Medical Journal, 2011
BACKGROUND: Malaria is a major public health problem in Sub-Saharan Africa where it kills a child under the age of five every 30 seconds. In Cameroon, malaria accounts for 40-45% of medical consultations, 57% of hospitalization days and 40% of mortality ...
Dickson Shey Nsagha, Anna Longdoh Njunda, Henri Lucien Foumou Kamga, Sarah Mboshi Nsagha, Jules Clement Nguedia Assob, Charles Shey Wiysonge, Earnest Njih Tabah, Alfred Kongnyu Njamnshi   +7 more
doaj   +1 more source

Eficacia de amodiaquina y sulfadoxina/pirimetamina en el tratamiento de malaria no complicada por Plasmodium falciparum en Nariño, Colombia, 1999-2002.

Biomédica: revista del Instituto Nacional de Salud, 2003
La resistencia a los antimaláricos es una de las causas del aumento de casos de malaria en el mundo. Desde el año 2000, el tratamiento de malaria no complicada por Plasmodium falciparum en Colombia ha sido la combinación de amodiaquina (AQ) y sulfadoxina/
Iveth J. González, Julio O. Padilla, Luis E. Giraldo, Nancy G. Saravia   +3 more
doaj   +1 more source