Results 121 to 130 of about 28,999 (273)

Ultra-performance liquid chromatography coupled with mass spectrometry profiling and evaluation of in vitro anti-Plasmodium falciparum activity of extracts from a Congolese Ancistrocladus species

Discover Chemistry
Malaria remains one of the leading causes of death globally, particularly in developing countries. This study aimed to investigate the antimalarial activity and UPLC-MS profiling of crude extracts from a new Ancistrocladus species collected in Banalia ...
Justin Bazibuhe Safari, Félicien Mushagalusa Kasali, Séverin Muyisa Kavatsurwa   +2 more
doaj   +1 more source

Tambjamines as Fast-Acting Multistage Antimalarials. [PDF]

Well-tolerated and novel antimalarials that can combat multiple stages of the parasite life cycle are desirable but challenging to discover and develop. Herein, we report results for natural product-inspired novel tambjamine antimalarials.
Madejczyk, Michael, Madejczyk, Michael S., Cooper, Roland A, Peyton, David H., Matthews, Holly, Reynolds, Kevin A, Reynolds, Kevin, Lee, Patricia, Rasmussen, Stephanie, Tumwebaze, Patrick, Orjuela-Sanchez, Pamela, Cooper, Roland, Winzeler, Elizabeth A., Kelly, Jane X., Caridha, Diana, Jin, Xiannu, Baum, Jake, Ceja, Frida G, Evans, Martin, Tumwebaze, Patrick K, Rosenthal, Philip, Kirby, Robert, Dodean, Rozalia A., Burrows, Jeremy N., Kancharla, Papireddy, Pybus, Brandon, Burrows, Jeremy N, Winzeler, Elizabeth, Dennis, William, Kelly, Jane X, Dennis, William E., Rosenthal, Philip J., Kumar, Amrendra, Reynolds, Kevin A., Dinh, Hieu T, Dinh, Hieu, Kirby, Robert W., Dodean, Rozalia, Pybus, Brandon S., Vuong, Chau, Lee, Patricia J., Rasmussen, Stephanie A, Li, Yuexin, Blount, Cameron, Pybus, Brandon S, Chetree, Ravi, Winzeler, Elizabeth A, Kirby, Robert W, Rasmussen, Stephanie A., Cooper, Roland A., Ceja, Frida G., Dodean, Rozalia A, Sousa, Jason, Duffy, James, Burrows, Jeremy, Delves, Michael J., Ceja, Frida, Black, Chad, Tumwebaze, Patrick K., Peyton, David, Rosenthal, Philip J, Meister, Stephan, Martin, Monica, Peyton, David H, Kelly, Jane, Nolan, Christina, Dennis, William E, Delves, Michael J, Rottmann, Matthias, Pannone, Kristina, Dinh, Hieu T., Roth, Alison, Delves, Michael, Madejczyk, Michael S, Nadeau, Robert, Leed, Susan, DeLuca, Jesse, Lee, Patricia J   +77 more
core   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Identification of a New Chemical Class of Antimalarials [PDF]

, 2017
The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials.
Heidmann, Bibia, Welford, Richard, Bozdech, Zbynek, Papastogiannidis, Petros, Fischli, Christoph, Voss, Till, Boss, Christoph, Wittlin, Sergio, Corminboeuf, Olivier, Kamber, Jolanda, Binkert, Christoph, Delahaye, Stephane, Brunner, Ralf, Brun, Reto, Kaiser, Marcel, Siegrist, Romain, Meyer, Solange, Aissaoui, Hamed   +17 more
core  

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Neuro-psychiatric effects of antimalarials

, 1997
Objective: To study the neuro-psychiatric adverse effects of antimalarial drugs. Setting: Persons who visited a Travel Clinic in Rotterdam over a period of 3 months.
Van Riemsdijk, M. M., van der Klauw, MM (Melanie), Stricker, Bruno, Stricker, B. H.Ch, Herings, RMC (Ron), van Heest, JAC, Herings, R. M.C., Van Der Klauw, M. M., Van Heest, J. A.C., van Riemsdijk, MM, Reedeker, F. R., Ligthelm, R. J., Reedeker, FR, Ligthelm, RJ   +13 more
core   +1 more source

Death after discharge among children living with HIV admitted with suspected sepsis in Uganda: A secondary analysis of two prospective observational studies

HIV Medicine, EarlyView.
Abstract Background Children living with HIV in low‐income countries contribute disproportionately to death after hospital discharge. This study investigates the effect of HIV on post‐discharge mortality and readmission by exploring a wide range of clinical, maternal and socioeconomic variables.
O. Mackenzie, C. Zhang, N. Kissoon, N. Ford, N. Sugandhi, E. Kumbakumba, J. Kabakyenga, C. Komugisha, N. K. Mugisha, M. O. Wiens   +9 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Antimalarials in Lupus Nephritis: How Strong Is the Evidence? [PDF]

SLE is a chronic multisystem autoimmune disease that affects the kidneys in approximately 50% of patients, with the prevalence rising to as high as 70% in certain populations, such as African American and Asian people.
Yandian, Federico, Sethi, Sanjeev, Caravaca-Fontán, Fernando, Fervenza, Fernando C., Zand, Ladan, Fervenza, Fernando C   +5 more
core   +1 more source