Results 141 to 150 of about 26,961 (258)

Resistance to Antimalarials [PDF]

Journal of Tropical Pediatrics, 2002
openaire   +2 more sources

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Unusual Palatal Pigmentation in a 71‐Year‐Old Patient

Oral Diseases, EarlyView.
Lucía Lago‐Méndez, Carlos Manuel de Neira de Paz, Pedro Diz‐Dios, Márcio Diniz‐Freitas   +3 more
wiley   +1 more source

Clinicopathological Features of Lupus Erythematosus Panniculitis (LEP): A Retrospective Analysis of 54 Cases

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Lupus Erythematosus Panniculitis (LEP) is a rare subtype of Cutaneous Lupus Erythematosus. It is a challenging disease to diagnose and treat due to limited understanding of its clinical and histopathological characteristics. Methods We conducted a retrospective review of 54 biopsy‐proven LEP cases evaluated at a dermatology referral
Maryam Nasimi, Narjes Ramezani, Kambiz Kamyab, Alireza Abdshah, Maryam Ghiasi, Sahar Montazeri, Hanie Babaie, Fatemeh Saberi   +7 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Comparative Analysis of Chlorhexidine Derivatives and Alternative Agents on Streptococcus mutans Viability, Biofilm Formation, and Gene Expression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Chlorhexidine gluconate and alexidine potently kill S. mutans, disrupt biofilms, and downregulate virulence genes, yet show moderate cytotoxicity. In contrast, sub‐MIC amoxicillin paradoxically promotes biofilm formation, highlighting the need for targeted antibiofilm therapies. ABSTRACT This study evaluates the antimicrobial and antibiofilm effects of
Hamideh Kamalloo, Mohammadreza Moeininejad, Maryam kiani golshoui, Fatemeh Samadyar, Ali Shivaee, Behrooz Sadeghi Kalani   +5 more
wiley   +1 more source

Deactivation Pathways in 2‐Ferrocenylmethyl‐5‐Aminoxazoles Synthesized via Ugi–Zhu Reaction: A Dewar–Chatt–Duncanson‐Type Interaction

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
The synthesis and full characterization are reported of 15 new ferrocenyl‐containing oxazoles via the Ugi–Zhu reaction, which is a special kind of MCR versatile to synthesize different types of heterocycles and polyheterocycles, and the DFT‐based study is performed using a high level of theory to rationalize the reactivity of synthesized compounds ...
Carlos E. Garduño‐Albino, Roberto E. Blanco‐Carapia, Ricardo Alfredo Luna‐Mora, Humberto Laguna‐Galindo, Eduardo González‐Zamora, Alejandro Islas‐Jácome   +5 more
wiley   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1028-1034, August 2026.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, Volume 32, Issue 27, 17 July 2026.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source