Results 81 to 90 of about 38,148 (251)

Antimaláricos e perfil lipídico em pacientes com lúpus eritematoso sistêmico Antimalarials and cholesterol profile of patients with systemic lupus erythematosus

Revista Brasileira de Reumatologia, 2011
Recentemente, vem-se atribuindo uma influência benéfica dos antimaláricos no perfil lipídico de pacientes com lúpus eritematoso sistêmico (LES). Neste estudo transversal, avaliamos o efeito da cloroquina nos níveis de colesterol de uma população ...
Carina Rossoni, Melissa Cláudia Bisi, Mauro Waldemar Keiserman, Henrique Luiz Staub   +3 more
doaj   +1 more source

Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Malaria control strategies emphasize the need for prompt and effective treatment of malaria episodes. To increase treatment efficacy, Tanzania changed its first-line treatment from chloroquine to sulphadoxine-pyrimethamine (SP) in 2001.
Manuel W Hetzel, June J Msechu, Catherine Goodman, Christian Lengeler, Brigit Obrist, S Patrick Kachur, Ahmed Makemba, Rose Nathan, Alexander Schulze, Hassan Mshinda, Ministry of Health (Tanzania), World Health Organization, UNICEF, Roll Back Malaria/World Health Organization, L von Seidlein, Committee on the Economics of Antimalarial Drugs, Board on Global Health, J Nsungwa-Sabiiti, D Zurovac, SC McCombie, World Health Organization, UNICEF, SC McCombie, MJ Hamel, C Goodman, R Brugha, World Health Organization, United Republic of Tanzania, A Battersby, CA Goodman, INDEPTH Network, T Smith, United Republic of Tanzania, C Drakeley, D Schellenberg, JRM Armstrong Schellenberg, M Tanner, SED Nsimba, SP Kachur, World Health Organization, JD Njau, U D'Alessandro   +38 more
core   +3 more sources

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, EarlyView.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2018
Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6 Yiyi Zhang,1 Chang Xu,6 Qianrui Li,1 Xin Sun,6 Haoming Tian,1 Sheyu Li1,7 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041,
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S   +10 more
doaj  

A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

npj Vaccines
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potential interactions of this combination affecting
Borimas Hanboonkunupakarn, Mavuto Mukaka, Podjanee Jittamala, Kittiyod Poovorawan, Pongphaya Pongsuwan, Lisa Stockdale, Samuel Provstgaard-Morys, Kesinee Chotivanich, Joel Tarning, Richard M. Hoglund, Natenapa Chimjinda, Katie Ewer, Fernando Ramos-Lopez, Nicholas P. J. Day, Arjen M. Dondorp, Adrian V. Hill, Nicholas J. White, Lorenz von Seidlein, Sasithon Pukrittayakamee   +18 more
doaj   +1 more source

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

Molecules, 2013
Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed.
Lucio H. Freitas-Junior, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Carolina Borsoi Moraes, Gina Frausin, Luiz Francisco Rocha e Silva, Stefanie Costa Pinto Lopes, Renata Braga Souza Lima, Fabio Trindade Maranhão Costa, Adrian Martin Pohlit   +10 more
doaj   +1 more source

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. [PDF]

, 2007
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection.
Anderson, T J C, Carlton, J, Day, N P J, Guthmann, J P, Imwong, M, Kim, J R, Looareesuwan, S, Nair, S, Nandy, A, Nosten, F, Pukrittayakamee, S, Snounou, G, Sudimack, D, Tanomsing, N, White, N J   +14 more
core   +2 more sources

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Costing Artemisinin-based Combination Therapy for Malaria in Tanzania [PDF]

, 2005
Malaria continues to be a major contributor to the burden of disease in Tanzania, with a prevalence of 33.39 percent nationally. As antimalarial resistance to sulfadoxine-pyrimethamine in Tanzania continues to grow, the government is in the process of ...
Derriennic, Yann, Wolf, Katherine
core  

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting.
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
core   +1 more source