Results 81 to 90 of about 28,999 (273)
Antiretrovirals as Antimalarial Agents [PDF]
The Journal of Infectious Diseases, 2004 Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 ...
S. Skinner-Adams, Tina +4 more
openaire +5 more sources
Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest? [PDF]
, 2021 We read with interest the paper of Graef et al recently published in your journal about the situation resulting from the massive use of antimalarials for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19), despite the fact that the
Villarreal, Laura +6 more
core
British Journal of Clinical Pharmacology, EarlyView.Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun +4 more
wiley +1 more source
A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents
Frontiers in ChemistryAntimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in
Romina E. Avanzo +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Tested susceptibility to antimalarials
Data for study on tested susceptibility to ...
London School of Hygiene & Tropical Medicine
core +2 more sources
Acute Kidney Injury in a Patient Receiving Antimalarial Therapy: A Case Report
Haseki Tıp Bülteni, 2020 In this article, we present a case of Plasmodium falciparum malaria in a male patient who developed acute kidney injury during antimalarial treatment.
Heval Can Bilek +2 more
doaj +1 more source
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4
, 2023 Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting ...
DA Fidock (14529620) +22 more
core
Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria
British Journal of Clinical Pharmacology, EarlyView.Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin +6 more
wiley +1 more source
Antimalarials: Pre-Clinical development update
, 2017 Diverse strategies exist for the development of novel antimalarials drug to tackle the increasing incidence of artemisin resistance. New molecules have been developed which hold a promise to cater to this unmet need.
Koustuv Chowdhury +6 more
core +1 more source