Results 81 to 90 of about 63,797 (281)
American Journal of Tropical Medicine and Hygiene, 2015 Counterfeit (or falsified) and substandard medicines pose a major public health risk. We describe the findings of Operation Storm I and II conducted in 2008–2009 to combat counterfeit medicines through partnership between national customs, Drug ...
Y. Yong +14 more
semanticscholar +1 more source
Nature Communications, 2014 The quest for new antimalarial drugs, especially those with novel modes of action, is essential in the face of emerging drug-resistant parasites. Here we describe a new chemical class of molecules, pyrazoleamides, with potent activity against human ...
A. Vaidya +30 more
semanticscholar +1 more source
Curing Perovskite Photovoltaics With Organic Functional Molecules: Progress, Mechanism, and Prospect
Interdisciplinary Materials, EarlyView.Leveraging the advantages of precision‐targeted design, excellent chemical stability, diverse geometric configuration, and economic viability, the application of medicinally derived organic functional molecules can accelerate curing multiple problems in perovskite photovoltaics, not only promoting synergistic effects among the functional layers, but ...
Jin Wang +9 more
wiley +1 more source
Potential antimalarials from African natural products: A reviw
Journal of Intercultural Ethnopharmacology, 2015 Malaria remains an overwhelming infectious disease with significant health challenges in African and other endemic countries globally. Resistance to antimalarial drugs has become one of the most momentous challenges to human health, and thus has ...
B. Lawal +6 more
semanticscholar +1 more source
Journal of Raman Spectroscopy, EarlyView.We report the development and use of a transmission Raman spectroscopy (TRS) system for a more accurate but nonintrusive way of authentication of API in coated HCQ tablets which otherwise is not possible using the backscattered (BS) configuration of Raman spectroscopy. The coating interference is found to be almost zero in case of the TRS and a greater
Vijay Kumar +5 more
wiley +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Cell Host and Microbe, 2013 Summary The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the infected cell.
Natalie J. Spillman +6 more
semanticscholar +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
Memorias do Instituto Oswaldo Cruz, 2014 In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned ...
Fernando Fonseca Val +6 more
doaj +1 more source
Advancing pharmacometrics in Africa—Transition from capacity development toward job creation
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai +10 more
wiley +1 more source