Results 61 to 70 of about 26,961 (258)

Use of antimalarials among participants who sought treatment for fever. [PDF]

, 2015
Use of antimalarials among participants who sought treatment for fever.
Seeba Amenga Etego (828398), Livesy Naafoe Abokyi (828395), Emmanuel Mahama (324670), Kwaku Poku Asante (96320), Anthony Kwarteng (733299), Patricia Akweongo (488556), Jennifer Ayaam (828397), Abubakari Sulemana (828396), Bernhards Ogutu (683944), Stephaney Gyaase (337622), David Dosoo (223143), Seth Owusu-Agyei (80063), Dennis Adu-Gyasi (324667)   +12 more
core   +1 more source

A Cautionary Tale: The Risks of Unproven Antimalarials [PDF]

A Cautionary Tale: The Risks of Unproven Antimalarials ...

core   +6 more sources

Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues

Drugs in Context, 2019
Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications.
Ashutosh M Shukla, Aparna Wagle Shukla
doaj   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Antimalarials and the fight against malaria in Brazil [PDF]

, 2009
Luiz MA Carmargo1, Saulo de Oliveira2, Sergio Basano3, Célia RS Garcia21ICBV-USP, Monte Negro, Rondônia, Brasil; 2Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, SP, Brazil ...
Célia RS Garcia, Luiz MA Carmargo, Sergio Basano, Saulo de Oliveira   +3 more
core  

Design, synthesis, and biological evaluation of multiple targeting antimalarials [PDF]

, 2021
Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug ...
Jiang, Lubin, Yu Rao, Tang, Tongke, Rao, Yu, Michel, Thomas, Brigitte Meunier, Thomas Michel, Yang, Yiqing, Zhenghui Huang, Wu, Yue, Wang, Liguo, Tongke Tang, Xiaolu Li, Ling, Liqin, Li, Xiaolu, Ke, Hangjun, Huang, Zhenghui, Maruthi Mulaka, Lubin Jiang, Yue Wu, Gao, Hongying, Meunier, Brigitte, Yiqing Yang, Liqin Ling, Hangjun Ke, Zhou, Jing, Liguo Wang, Hongying Gao, Jing Zhou, Mulaka, Maruthi   +29 more
core   +1 more source

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

Memorias do Instituto Oswaldo Cruz, 2014
Due to the recent advances of atovaquone, a naphthoquinone, through clinical trials as treatment for malarial infection, 19 quinone derivatives with previously reported structures were also evaluated for blood schizonticide activity against the malaria ...
Nicolli Bellotti de Souza, Isabel M de Andrade, Paula F Carneiro, Guilherme AM Jardim, Isadora MM de Melo, Eufrânio N da Silva Júnior, Antoniana Ursine Krettli   +6 more
doaj   +1 more source

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

Microbiology Spectrum, 2023
Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed.
Oriana Kreutzfeld, Patrick K. Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Melissa D. Conrad, Stephanie A. Rasmussen, Jennifer Legac, Ozkan Aydemir, David Giesbrecht, Barbara Forte, Peter Campbell, Alasdair Smith, Hiroki Kano, Samuel L. Nsobya, Benjamin Blasco, Maelle Duffey, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal   +20 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Evaluation of In-Hospital Management for Febrile Illness\ud in Northern Tanzania before and after 2010 World Health\ud Organization Guidelines for the Treatment of Malaria [PDF]

, 2014
In 2010, the World Health Organization (WHO) published updated guidelines emphasizing and expanding recommendations for a parasitological confirmation of malaria before treating with antimalarials. This study aimed to assess differences in historic (2007–
Rubach, Matthew P., Biggs, Holly M, Reddy, Elizabeth A., Andrew M Moon, Elizabeth A Reddy, Crump, John A., Wilbrod Saganda, Holly M Biggs, John A Crump, Saganda, Wilbrod, Venace P Maro, Biggs, Holly M., Moon, Andrew M., Maro, Venace P., Crump, John A, Maro, Venace P, Matthew P Rubach, Reddy, Elizabeth A, Moon, Andrew M, Rubach, Matthew P   +19 more
core   +1 more source