Results 41 to 50 of about 28,999 (273)

The Ignored Issue of Poor-Quality Antimalarials

, 2021
Malaria is a preventable and curable disease that, despite numerous advances in treatment and prevention, is still annually responsible for hundreds of thousands of deaths primarily in sub-Saharan Africa and Southeast Asia. The current epidemic is caused
Finkel, Daniela
core   +1 more source

Community-Based Malaria Testing Reduces Polypharmacy in a Population-Based Survey of Febrile Illness in Western Kenya

International Journal of Public Health, 2022
Objective: The objective was to describe the relationship between the location of care, the malaria test result, and the type of medicine consumed for the fever, and to determine whether community-based access to malaria testing reduced polypharmacy ...
Jeremiah Laktabai, Jeremiah Laktabai, Alyssa C. Platt, Elizabeth Turner, Elizabeth Turner, Indrani Saran, Joseph Kipkoech, Diana Menya, Wendy Prudhomme O’Meara   +8 more
doaj   +1 more source

Reappraisal of Antimalarials in Interferonopathies: New Perspectives for Old Drugs [PDF]

, 2017
The story of antimalarials as antinflammatory drugs dates back several centuries. Chinin, the extract of the Cinchona bark, has been exploited since the 18th century for its antimalarial and antifebrile properties. Later, during the Second World War, the
Piscianz, Elisa, Sapra, Pooja, Tommasini, Alberto, Sharma, Rajan, Tesser, Alessandra, Cuzzoni, Eva   +5 more
core   +1 more source

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

Discovering Antimalarials a New Strategy [PDF]

, 2002
Recent discoveries have uncovered some key processes that occur in the food vacuole of the malarial parasite. Consequently, new families of potential antimalarials that inhibit HRP-2, a hitherto unexplored drug target, were identified using a novel ...
Egan, Timothy J
core   +1 more source

Evaluation of In-Hospital Management for Febrile Illness\ud in Northern Tanzania before and after 2010 World Health\ud Organization Guidelines for the Treatment of Malaria [PDF]

, 2014
In 2010, the World Health Organization (WHO) published updated guidelines emphasizing and expanding recommendations for a parasitological confirmation of malaria before treating with antimalarials. This study aimed to assess differences in historic (2007–
Rubach, Matthew P., Biggs, Holly M, Reddy, Elizabeth A., Andrew M Moon, Elizabeth A Reddy, Crump, John A., Wilbrod Saganda, Holly M Biggs, John A Crump, Saganda, Wilbrod, Venace P Maro, Biggs, Holly M., Moon, Andrew M., Maro, Venace P., Crump, John A, Maro, Venace P, Matthew P Rubach, Reddy, Elizabeth A, Moon, Andrew M, Rubach, Matthew P   +19 more
core   +1 more source

Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum

Parasite, 2007
Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains.
Garavito G., Bertani S., Rincon J., Maurel S., Monje M.C., Landau I., Valentin A., Deharo E.   +7 more
doaj   +1 more source

The Rare, the Best: Spread of Antimalarial-Resistant Plasmodium falciparum Parasites by Anopheles Mosquito Vectors

Microbiology Spectrum, 2021
The emergence of resistance to antimalarials has prompted the steady switch to novel therapies for decades. Withdrawal of antimalarials, such as chloroquine in sub-Saharan Africa in the late 1990s, led to rapid declines in the prevalence of resistance ...
Antoine Berry, Sandie Menard, Sandrine E. Nsango, Luc Abate, Didier Concordet, Majoline Tchioffo Tsapi, Xavier Iriart, Parfait H. Awono-Ambéné, Benjamin Roche, Isabelle Morlais   +9 more
doaj   +1 more source

Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia‐Pacific Lupus Collaboration Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective This research article aims to describe the prevalence, associations, and health‐related quality of life (HRQoL) impact of mucocutaneous features of systemic lupus erythematosus (SLE). Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analyzed (2013–2021).
Amanda M. Saracino, Yanjie Hao, Dylan Hansen, Yi‐Hsing Chen, Alberta Hoi, Vera Golder, Jiacai Cho, Aisha Lateef, Worawit Louthrenoo, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Chak Sing Lau, Shirley Chan, Zhanguo Li, Hai‐hong Yao, Sargunan Sockalingam, B. M. D. B. Basnayake, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Jun Kikuchi, Yuko Kaneko, Tsutomu Takeuchi, Madelynn Chan, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Geraldine Hassett, Kristine Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Michael Tee, Cherica Tee, Naoaki Ohkubo, Yoshiya Tanaka, Rangi Kandane‐Rathnayake, Eric Morand, Shereen Oon, Mandana Nikpour   +42 more
wiley   +1 more source

Assessing the Impact of Substandard and Falsified Antimalarials in Benin [PDF]

, 2021
Substandard and falsified antimalarials contribute to the global malaria burden by increasing the risk of treatment failures, adverse events, unnecessary health expenditures, and avertable deaths.
Vy Bui, Colleen Higgins, Sachiko Ozawa, Sarah Laing   +3 more
core   +1 more source