Results 31 to 40 of about 28,999 (273)

Malaria: The Past and the Present

Microorganisms, 2019
Malaria is a severe disease caused by parasites of the genus Plasmodium, which is transmitted to humans by a bite of an infected female mosquito of the species Anopheles.
Jasminka Talapko, Ivana Škrlec, Tamara Alebić, Melita Jukić, Aleksandar Včev   +4 more
doaj   +1 more source

New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]

Journal of the Serbian Chemical Society, 2021
Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor, Selaković Milica, Tot Mikloš, Verbić Tatjana, Srbljanović Jelena, Štajner Tijana, Đurković-Đaković Olgica, Šolaja Bogdan   +7 more
doaj   +1 more source

Knowledge of Malaria and Its Uncomplicated Treatment with Argemone mexicana L. in Selected Districts of Jimma Zone, Oromia Regional State, Ethiopia: A Community-Based Cross Sectional Survey

Infection and Drug Resistance, 2022
Tamirat Tekassa,1 Gemmechu Hasen,1 Hailu Merga,2 Anne-Laure Cavin,3 Bertrand Graz,3 Sultan Suleman1 1School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia Regional State, Ethiopia; 2Department of Epidemiology, Institute of Health ...
Tekassa T, Hasen G, Merga H, Cavin AL, Graz B, Suleman S   +5 more
doaj  

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

Microbiology Spectrum, 2023
Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed.
Oriana Kreutzfeld, Patrick K. Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Melissa D. Conrad, Stephanie A. Rasmussen, Jennifer Legac, Ozkan Aydemir, David Giesbrecht, Barbara Forte, Peter Campbell, Alasdair Smith, Hiroki Kano, Samuel L. Nsobya, Benjamin Blasco, Maelle Duffey, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal   +20 more
doaj   +1 more source

Global Phenotypic Screening for Antimalarials [PDF]

, 2012
Malaria, a devastating infectious disease caused by Plasmodium spp., leads to roughly 655,000 deaths per year, mostly of African children. To compound the problem, drug resistance has emerged to all classical antimalarials and may be emerging for ...
Shelat, Anang A., Gamo, Francisco-Javier, Guiguemde, W. Armand, Guy, R. Kiplin, Garcia-Bustos, Jose F., Diagana, Thierry T.   +5 more
core   +1 more source

The COVID-19 Treatment Landscape: A South African Perspective on a Race Against Time

Frontiers in Medicine, 2021
The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which causes local tissue damage as well ...
Candice Laverne Hendricks, Candice Herd, Marcel Nel, Gregory Tintinger, Michael Sean Pepper   +4 more
doaj   +1 more source

Poor-quality antimalarials further health inequities in Uganda [PDF]

, 2019
Substandard and falsified medications are a major threat to public health, directly increasing the risk of treatment failure, antimicrobial resistance, morbidity, mortality and health expenditures.
Evans, Daniel R, Higgins, Colleen R, Laing, Sarah K, Ozawa, Sachiko, Awor, Phyllis   +4 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

Pharmaceuticals, 2020
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon   +3 more
doaj   +1 more source

The Knockout for G Protein-Coupled Receptor-Like PfSR25 Increases the Susceptibility of Malaria Parasites to the Antimalarials Lumefantrine and Piperaquine but Not to Medicine for Malaria Venture Compounds

Frontiers in Microbiology, 2021
Previously we have reported that the G protein-coupled receptor (GPCR)-like PfSR25 in Plasmodium falciparum is a potassium (K+) sensor linked to intracellular calcium signaling and that knockout parasites (PfSR25-) are more susceptible to oxidative ...
Benedito M. Santos, Bárbara K. M. Dias, Myna Nakabashi, Celia R. S. Garcia   +3 more
doaj   +1 more source