Results 21 to 30 of about 28,999 (273)

Adverse events in rheumatoid arthritis patients under antimalarial treatment—Is there cardiovascular compromise?

Frontiers in Drug Safety and Regulation, 2023
Introduction: The antimalarials chloroquine and hydroxychloroquine have been used for several decades in treating malaria and some autoimmune diseases—mainly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)—with excellent efficacy and ...
Pedro Santos-Moreno, Linda Ibatá, Susan Martínez, Gabriel-Santiago Rodríguez-Vargas, Laura Villarreal, Pedro Rodríguez, Wilberto Rivero, Fernando Rodríguez-Florido, Adriana Rojas-Villarraga   +8 more
doaj   +1 more source

High adherence to antimalarials and antibiotics under integrated community case management of illness in children less than five years in eastern Uganda.

PLoS ONE, 2013
BackgroundDevelopment of resistance to first line antimalarials led to recommendation of artemisinin based combination therapies (ACTs). High adherence to ACTs provided by community health workers (CHWs) gave reassurance that community based ...
Joan N Kalyango, Elizeus Rutebemberwa, Charles Karamagi, Edison Mworozi, Sarah Ssali, Tobias Alfven, Stefan Peterson   +6 more
doaj   +1 more source

Antimalarials may reduce cancer risk in patients with systemic lupus erythematosus: a systematic review and meta-analysis of prospective studies

Annals of Medicine, 2021
Objective To investigate the effect of antimalarials on cancer risk in patients with systemic lupus erythematosus (SLE).Methods PubMed, EMBASE, Web of Science, and the Cochrane Library were searched from their inception to October 3, 2020. Relative risk (
Xian-Bao Li, Nv-Wei Cao, Xiu-Jie Chu, Hao-Yue Zhou, Hua Wang, Si-Jie Yu, Dong-Qing Ye, Bao-Zhu Li   +7 more
doaj   +1 more source

Substandard antimalarials available in Afghanistan: a case for assessing the quality of drugs in resource poor settings. [PDF]

, 2015
Good-quality antimalarials are crucial for the effective treatment and control of malaria. A total of 7,740 individual and packaged tablets, ampoules, and syrups were obtained from 60 randomly selected public (N = 35) and private outlets (N = 25) in ...
Wyk, Albert van, Mohammed, Nader, Harparkash Kaur, Jan, Sakhi, Mojadidi, Mohammed Khalid, Lalani, Mirza, Mirza Lalani, Rishtya Meena Kakar, Mohammed Khalid Mojadidi, Naiela Mailk, Leslie, Toby, Kaur, Harparkash, Mailk, Naiela, Nader Mohammed, Albert Van Wyk, Kakar, Rishtya Meena, Sakhi Jan, Toby Leslie   +17 more
core   +1 more source

In vitro drug interaction of ionophores with artemisinin and chloroquine against Plasmodium falciparum 3D7 blood-stage infection

Frontiers in Drug Discovery, 2023
The prevalence of clinical resistance of P. falciparum towards artemisinin and its partner drugs has significantly hampered malarial chemotherapy. To circumvent this situation, identifying a new class of partner drugs with significant anti-malarial ...
Vinoth Rajendran, Keerthana Gurukkalot
doaj   +1 more source

Single-cell gene regulatory network analysis reveals potential mechanisms of action of antimalarials against SARS-CoV-2

, 2020
The efficiency of antimalarials, chloroquine (CQ) and hydroxychloroquine (HCQ), in the prevention and treatment of coronavirus disease 2019 (COVID-19) is under intense debate.
James Cai, Daniel Camilo Osorio Hurtado
core   +1 more source

Comparison of Health Service Utilization for Febrile Children Before and After Introduction of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy in Rural Papua New Guinea

Frontiers in Public Health, 2018
BackgroundIn Papua New Guinea (PNG), a malaria treatment policy using rapid diagnostic tests (RDTs) plus artemisinin-based combination therapy (ACT) was widely introduced to rural communities in 2012.
Takahiro Tsukahara, Takahiro Tsukahara, Takuma Sugahara, Takuro Furusawa, Francis Wanak Hombhanje   +4 more
doaj   +1 more source

Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA)

Frontiers in Pharmacology, 2023
Due to the outbreak of the SARS-CoV-2 virus, drug repurposing and Emergency Use Authorization have been proposed to treat the coronavirus disease 2019 (COVID-19) during the pandemic. While the efficiency of the drugs has been discussed, it was identified
Seung-Hyun Yoon, Seung-Hyun Yoon, Hyun-Lee Lee, Da Un Jeong, Ki Moo Lim, Seong-Jun Park, Ki-Suk Kim   +6 more
doaj   +1 more source

Artemisinin antimalarials: preserving the "magic bullet" [PDF]

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
core   +1 more source

Susceptibilidad in vitro de aislamientos colombianos de Plasmodium falciparum a diferentes antipalúdicos

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. Los estudios de susceptibilidad in vitro de Plasmodium falciparum a los medicamentos antipalúdicos son herramientas importantes para vigilar la utilidad de esos medicamentos; tales estudios son escasos en Colombia. Objetivo.
Silvia Blair, Eliana Arango, Jaime Carmona Fonseca   +2 more
doaj   +1 more source