Results 21 to 30 of about 29,390 (250)
Antiretrovirals as Antimalarial Agents [PDF]
The Journal of Infectious Diseases, 2004 Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 ...
S. Skinner-Adams, Tina +4 more
openaire +5 more sources
Malaria: The Past and the Present
Microorganisms, 2019 Malaria is a severe disease caused by parasites of the genus Plasmodium, which is transmitted to humans by a bite of an infected female mosquito of the species Anopheles.
Jasminka Talapko +4 more
doaj +1 more source
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
Microbiology Spectrum, 2023 Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed.
Oriana Kreutzfeld +20 more
doaj +1 more source
New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2021 Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor +7 more
doaj +1 more source
Infection and Drug Resistance, 2022 Tamirat Tekassa,1 Gemmechu Hasen,1 Hailu Merga,2 Anne-Laure Cavin,3 Bertrand Graz,3 Sultan Suleman1 1School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia Regional State, Ethiopia; 2Department of Epidemiology, Institute of Health ...
Tekassa T +5 more
doaj
The COVID-19 Treatment Landscape: A South African Perspective on a Race Against Time
Frontiers in Medicine, 2021 The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which causes local tissue damage as well ...
Candice Laverne Hendricks +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji +5 more
wiley +2 more sources
Reappraisal of Antimalarials in Interferonopathies: New Perspectives for Old Drugs [PDF]
, 2017 The story of antimalarials as antinflammatory drugs dates back several centuries. Chinin, the extract of the Cinchona bark, has been exploited since the 18th century for its antimalarial and antifebrile properties. Later, during the Second World War, the
Piscianz, Elisa +5 more
core +1 more source
Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
Pharmaceuticals, 2020 This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 Previously we have reported that the G protein-coupled receptor (GPCR)-like PfSR25 in Plasmodium falciparum is a potassium (K+) sensor linked to intracellular calcium signaling and that knockout parasites (PfSR25-) are more susceptible to oxidative ...
Benedito M. Santos +3 more
doaj +1 more source