Results 11 to 20 of about 26,961 (258)

Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation [PDF]

Scientific Reports
We explored whether isotope ratio mass spectrometry (IRMS) is useful to investigate the origin of falsified antimalarials. Forty-four falsified and genuine antimalarial samples (artesunate, artemether-lumefantrine, dihydroartemisinin-piperaquine and ...
Paul N. Newton, Lesley A. Chesson, Mayfong Mayxay, Arjen Dondorp, Patricia Tabernero, John D. Howa, Thure E. Cerling   +6 more
doaj   +3 more sources

Single-cell gene regulatory network analysis reveals potential mechanisms of action of antimalarials against SARS-CoV-2 [PDF]

, 2020
The efficiency of antimalarials, chloroquine (CQ) and hydroxychloroquine (HCQ), in the prevention and treatment of coronavirus disease 2019 (COVID-19) is under intense debate.
James Cai, Daniel Camilo Osorio Hurtado
core   +1 more source

Hydroxychloroquine and Antimalarials [PDF]

The Journal of Rheumatology, 2019
We read the editorial by Sandhu, et al1 about antimalarial-induced cardiomyopathy in systemic lupus erythematosus2, and we want to point out some inaccuracies in the brief review of the history of antimalarials that they presented.
LUIS CAMINAL-MONTERO, SILVIA SUÁREZ-DÍAZ   +1 more
openaire   +2 more sources

Prevalence of malaria resistance-associated mutations in Plasmodium falciparum circulating in 2017–2018, Bo, Sierra Leone

Frontiers in Microbiology, 2022
IntroductionIn spite of promising medical, sociological, and engineering strategies and interventions to reduce the burden of disease, malaria remains a source of significant morbidity and mortality, especially among children in sub-Saharan Africa.
Tomasz A. Leski, Chris Rowe Taitt, Sophie M. Colston, Umaru Bangura, Andrew Holtz, Chadwick Y. Yasuda, Nathanael D. Reynolds, Joseph Lahai, Joseph M. Lamin, Victoria Baio, Rashid Ansumana, Rashid Ansumana, David A. Stenger, Gary J. Vora   +13 more
doaj   +1 more source

Adverse events in rheumatoid arthritis patients under antimalarial treatment—Is there cardiovascular compromise?

Frontiers in Drug Safety and Regulation, 2023
Introduction: The antimalarials chloroquine and hydroxychloroquine have been used for several decades in treating malaria and some autoimmune diseases—mainly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)—with excellent efficacy and ...
Pedro Santos-Moreno, Linda Ibatá, Susan Martínez, Gabriel-Santiago Rodríguez-Vargas, Laura Villarreal, Pedro Rodríguez, Wilberto Rivero, Fernando Rodríguez-Florido, Adriana Rojas-Villarraga   +8 more
doaj   +1 more source

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4 [PDF]

, 2023
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting ...
DA Fidock (14529620), X Zhang (6084905), B Chandra Maity (19861182), TD Ashton (14467038), T Yeo (13371246), KE Jarman (19453840), A Churchyard (10042406), AF Cowman (14467050), MG Dans (14461737), D Qiu (13534753), J Baum (13685923), KN Lowes (14461743), BE Sleebs (14461755), S Brand (7776398), AM Lehane (15822026), AC Uhlemann (14527571), A Ngo (9854420), KA Schindler (22234438), PF Jackson (19453858), D Baud (17409018), P Favuzza (13410966), H Park (7811786), N De (19561534)   +22 more
core   +3 more sources

Clinical Characteristics and Management of Patients With Clinical Amyopathic Dermatomyositis: A Retrospective Study of 64 Patients at a Tertiary Dermatology Department

Frontiers in Medicine, 2021
Background: Clinical amyopathic dermatomyositis (CADM) represents a subtype of 5–20% of patients with dermatomyositis (DM), which can be categorized into amyopathic dermatomyositis (ADM) and hypomyopathic dermatomyositis (HDM).
Keyun Tang, Hanlin Zhang, Hongzhong Jin
doaj   +1 more source

Substandard antimalarials available in Afghanistan: a case for assessing the quality of drugs in resource poor settings. [PDF]

, 2015
Good-quality antimalarials are crucial for the effective treatment and control of malaria. A total of 7,740 individual and packaged tablets, ampoules, and syrups were obtained from 60 randomly selected public (N = 35) and private outlets (N = 25) in ...
Wyk, Albert van, Mohammed, Nader, Harparkash Kaur, Jan, Sakhi, Mojadidi, Mohammed Khalid, Lalani, Mirza, Mirza Lalani, Rishtya Meena Kakar, Mohammed Khalid Mojadidi, Naiela Mailk, Leslie, Toby, Kaur, Harparkash, Mailk, Naiela, Nader Mohammed, Albert Van Wyk, Kakar, Rishtya Meena, Sakhi Jan, Toby Leslie   +17 more
core   +1 more source

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains [PDF]

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

Comparison of Health Service Utilization for Febrile Children Before and After Introduction of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy in Rural Papua New Guinea

Frontiers in Public Health, 2018
BackgroundIn Papua New Guinea (PNG), a malaria treatment policy using rapid diagnostic tests (RDTs) plus artemisinin-based combination therapy (ACT) was widely introduced to rural communities in 2012.
Takahiro Tsukahara, Takahiro Tsukahara, Takuma Sugahara, Takuro Furusawa, Francis Wanak Hombhanje   +4 more
doaj   +1 more source