Results 11 to 20 of about 63,797 (281)

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

Journal of Medicinal Chemistry, 2023
There is an urgent need to populate the antimalarial clinical portfolio with new candidates because of resistance against frontline antimalarials. To discover new antimalarial chemotypes, we performed a high-throughput screen of the Janssen Jumpstarter ...
T. Ashton, Madeline G. Dans, P. Favuzza, A. Ngo, Adele M. Lehane, Xinxin Zhang, Deyun Qiu, Bikash Chandra Maity, Nirupam De, Kyra A. Schindler, Tomas Yeo, Heekuk Park, A. Uhlemann, Alisje Churchyard, J. Baum, D. Fidock, K. Jarman, K. Lowes, Delphine Baud, S. Brand, P. Jackson, A. Cowman, B. Sleebs   +22 more
semanticscholar   +1 more source

Assessing Risks of Plasmodium falciparum Resistance to Select Next-Generation Antimalarials

Trends in Parasitology, 2021
Strategies to counteract or prevent emerging drug resistance are crucial for the design of next-generation antimalarials. In the past, resistant parasites were generally identified following treatment failures in patients and compounds would have to be ...
M. Duffey, Benjamin Blasco, J. Burrows, T. Wells, D. Fidock, D. Leroy   +5 more
semanticscholar   +1 more source

Multidimensional Immune Profiling of Cutaneous Lupus Erythematosus In Vivo Stratified by Patient Response to Antimalarials

Arthritis & Rheumatology, 2022
The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of inflammatory processes among patients.
J. Patel, T. Vazquez, Felix Chin, E. Keyes, D. Yan, D. Diaz, M. Grinnell, Meena R. Sharma, Yubin Li, R. Feng, G. Sprow, J. Dan, V. Werth   +12 more
semanticscholar   +1 more source

Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments

Molecules, 2021
Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease.
Mélanie Fonte, Natália Tassi, P. Gomes, Cátia Teixeira   +3 more
semanticscholar   +1 more source

Quinoline Antimalarials Increase the Antibacterial Activity of Ampicillin

Frontiers in Microbiology, 2021
Bacterial and malaria co-infections are common in malaria endemic countries and thus necessitate co-administration of antibiotics and antimalarials. There have long been anecdotal clinical reports of interactions between penicillins and antimalarial ...
O. Olateju, C. Babalola, O. Olubiyi, O. Kotila, D. A. Kwasi, A. Oaikhena, I. Okeke   +6 more
semanticscholar   +1 more source

Prevalence of malaria resistance-associated mutations in Plasmodium falciparum circulating in 2017–2018, Bo, Sierra Leone

Frontiers in Microbiology, 2022
IntroductionIn spite of promising medical, sociological, and engineering strategies and interventions to reduce the burden of disease, malaria remains a source of significant morbidity and mortality, especially among children in sub-Saharan Africa.
Tomasz A. Leski, Chris Rowe Taitt, Sophie M. Colston, Umaru Bangura, Andrew Holtz, Chadwick Y. Yasuda, Nathanael D. Reynolds, Joseph Lahai, Joseph M. Lamin, Victoria Baio, Rashid Ansumana, Rashid Ansumana, David A. Stenger, Gary J. Vora   +13 more
doaj   +1 more source

Hydroxychloroquine and Antimalarials [PDF]

The Journal of Rheumatology, 2019
We read the editorial by Sandhu, et al1 about antimalarial-induced cardiomyopathy in systemic lupus erythematosus2, and we want to point out some inaccuracies in the brief review of the history of antimalarials that they presented.
LUIS CAMINAL-MONTERO, SILVIA SUÁREZ-DÍAZ   +1 more
openaire   +2 more sources

Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Emerging antimalarial drug resistance may undermine current efforts to control and eliminate Plasmodium vivax, the most geographically widespread yet neglected human malaria parasite.
M. U. Ferreira, Taís Nóbrega de Sousa, Gabriel W. Rangel, I. C. Johansen, R. M. Corder, S. Ladeia-Andrade, J. Gil   +6 more
semanticscholar   +1 more source

Adverse events in rheumatoid arthritis patients under antimalarial treatment—Is there cardiovascular compromise?

Frontiers in Drug Safety and Regulation, 2023
Introduction: The antimalarials chloroquine and hydroxychloroquine have been used for several decades in treating malaria and some autoimmune diseases—mainly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)—with excellent efficacy and ...
Pedro Santos-Moreno, Linda Ibatá, Susan Martínez, Gabriel-Santiago Rodríguez-Vargas, Laura Villarreal, Pedro Rodríguez, Wilberto Rivero, Fernando Rodríguez-Florido, Adriana Rojas-Villarraga   +8 more
doaj   +1 more source

New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells

Biomolecules, 2020
Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy ...
D. Duarte, N. Vale
semanticscholar   +1 more source