Results 91 to 100 of about 28,999 (273)

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Intramolecular Hydrogen Bonds in Conformers of Quinine and Quinidine: An HF, MP2 and DFT Study

Molecules, 2017
Quinine is an alkaloid with powerful antimalarial activity, isolated from the bark of Peru’s cinchona trees. Quinidine is an erythro diastereoisomer of quinine also exhibiting antimalarial activity.
Mireille K. Bilonda, Liliana Mammino
doaj   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2018
Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6 Yiyi Zhang,1 Chang Xu,6 Qianrui Li,1 Xin Sun,6 Haoming Tian,1 Sheyu Li1,7 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041,
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S   +10 more
doaj  

A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

npj Vaccines
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potential interactions of this combination affecting
Borimas Hanboonkunupakarn, Mavuto Mukaka, Podjanee Jittamala, Kittiyod Poovorawan, Pongphaya Pongsuwan, Lisa Stockdale, Samuel Provstgaard-Morys, Kesinee Chotivanich, Joel Tarning, Richard M. Hoglund, Natenapa Chimjinda, Katie Ewer, Fernando Ramos-Lopez, Nicholas P. J. Day, Arjen M. Dondorp, Adrian V. Hill, Nicholas J. White, Lorenz von Seidlein, Sasithon Pukrittayakamee   +18 more
doaj   +1 more source

Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold

, 2016
Mithun Rudrapal, Dipak Chetia Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India Abstract: Malaria disease continues to be a major health problem worldwide due to the emergence of multidrug-resistant strains of Plasmodium ...
Chetia D, Rudrapal M
core  

A Review of Quinolone Antimalarials

, 2020
Malaria affects millions of people worldwide. Resistance to drugs that treat malaria has increased the demand for efficient drugs. The search for antimalarial drugs has led to the synthesis of a vast number of quinolone analogues as potential ...
Velazquez, Miriam
core   +1 more source

Knowledge of Malaria and Its Uncomplicated Treatment with Argemone mexicana L. in Selected Districts of Jimma Zone, Oromia Regional State, Ethiopia: A Community-Based Cross Sectional Survey [Corrigendum]

Infection and Drug Resistance, 2022
Tekassa T, Hasen G, Merga H, Cavin AL, Graz B, Suleman S. Infect Drug Resist. 2022;15:3087-3095. Page 3087, Introduction, line 2, the text “4,50,000” should read “450,000”.
Tekassa T, Hasen G, Merga H, Cavin AL, Graz B, Suleman S   +5 more
doaj  

Hydroxychloroquine‐induced erythema multiforme

Clinical Case Reports, 2020
Hydroxychloroquine is a commonly used medication and rarely may result in development of erythema multiforme. This potential cutaneous side effect should be highlighted in information given to patients prior to hydroxychloroquine commencement.
Dimitra Koumaki, Vasiliki Koumaki, George Bertsias, Sotirios Boumpoucheropoulos, Alexander Katoulis, Maria Stefanidou, Orestis Miaris, George Evangelou, Kyriaki Zografaki, Sabine Elke Krueger‐Krasagakis, Konstantinos Krasagakis   +10 more
doaj   +1 more source

Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1 as Diagnostic Biomarkers and Therapeutic Targets in Sepsis

Journal of Clinical Laboratory Analysis, EarlyView.
Integrative bioinformatics and experimental validation of FCER1G, IL1R2, and BST1 as biomarkers and therapeutic targets in neonatal sepsis. ABSTRACT Background Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient specificity.
Junjie Li, Guanghui Xiu, Ping Liu, Xianzhong Chen, Kailv Zhou, Yunfeng Yang   +5 more
wiley   +1 more source