Results 91 to 100 of about 26,961 (258)

Antimaláricos e perfil lipídico em pacientes com lúpus eritematoso sistêmico Antimalarials and cholesterol profile of patients with systemic lupus erythematosus

Revista Brasileira de Reumatologia, 2011
Recentemente, vem-se atribuindo uma influência benéfica dos antimaláricos no perfil lipídico de pacientes com lúpus eritematoso sistêmico (LES). Neste estudo transversal, avaliamos o efeito da cloroquina nos níveis de colesterol de uma população ...
Carina Rossoni, Melissa Cláudia Bisi, Mauro Waldemar Keiserman, Henrique Luiz Staub   +3 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials [PDF]

, 2016
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic procedures and characterized by low potential for developing resistance are urgently needed.
Nicoletta Basilico (806898), Salvatore Sanna Coccone (1789462), Stefano Marini (173645), Simon Croft (1696312), Matthias Rottmann (124987), Caterina Fattorusso (1338522), Sonja Keller-Maerki (2283118), Giuseppe Campiani (1714282), Marco Persico (1338504), Giovanna Guiso (436081), Gagan Kukreja (2012728), Vanessa Yardley (2179120), Silvio Caccia (436082), Ettore Novellino (333902), Bhupendra P. Joshi (2055916), Stefania Butini (1714288), Vito Nacci (2396542), Reto Brun (41511), Matteo Bernetti (2055922), Massimiliano Coletta (173635), Sandra Gemma (1714309), Isabella Fiorini (2012737), Donatella Taramelli (736311), Silvia Parapini (806899)   +23 more
core   +1 more source

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2018
Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6 Yiyi Zhang,1 Chang Xu,6 Qianrui Li,1 Xin Sun,6 Haoming Tian,1 Sheyu Li1,7 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041,
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S   +10 more
doaj  

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

Molecules, 2013
Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed.
Lucio H. Freitas-Junior, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Carolina Borsoi Moraes, Gina Frausin, Luiz Francisco Rocha e Silva, Stefanie Costa Pinto Lopes, Renata Braga Souza Lima, Fabio Trindade Maranhão Costa, Adrian Martin Pohlit   +10 more
doaj   +1 more source

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. [PDF]

, 2009
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic procedures and characterized by low potential for developing resistance are urgently needed.
E. Novellino, Gemma, S, Gemma S., Fiorini, I., Brun R., Basilico, Nicoletta, Kukreja, Gagan, Bernetti, M., Basilico, N., Nacci, V, Coletta, M, S. Parapini, Fiorini, Isabella, Butini, S., Coccone, Salvatore Sanna, Brun, R, Bernetti, M, Coccone S. S., Basilico N., M. Rottmann, S. Marini, Coletta, Massimiliano, Taramelli, Donatella, S. Caccia, Persico, Marco, Sanna Coccone, Salvatore, C. Fattorusso, Persico, M, Brun, R., Novellino, E, Marini, Stefano, Kellere Maerki, S., M. Coletta, Keller-Maerki S.,, Campiani, G, Parapini, S, Joshi, BP, Parapini S., Guiso, G, Coletta M., Marini, S, Rottmann M., Nacci, V., D. Taramelli, Taramelli, D, Marini S., N. Basilico, Yardley, V., M. Persico, Parapini, S., Gemma, S., Kukreja G., Fattorusso, C., Caccia, S., Bernetti M., Novellino, Ettore, Caccia, S, Caccia S., Taramelli, D., S. Croft, Coccone, S, Keller-Maerki, S, S. S. Coccone, G. Guiso, Joshi, Bhupendra P, Persico, M., Kukreja, G., Butini, Stefania, Keller-Maerki, Sonja, G. Campiani, Novellino, E., Croft, S, Yardley, V, Joshi Bhupendra P., Taramelli D., Nacci, Vito, Coccone, SS, G. Kurkreja, Rottmann, M., Coletta, M., S. Keller Maerki, Campiani, G., Basilico, N, R. Brun, Joshi, B, Bernetti, Matteo, Guiso G., M. Bernetti, Guiso, G., B. P. Joshi, Croft, S., Rottmann, M, Croft S., Joshi, B. P., Nacci V., Fiorini, I, S. Gemma, Yardley V., Butini, S, Fattorusso, Caterina, Butini S., I. Fiorini, Keller Maerki S., V. Nacci, S. Butini, V. Yardley, Keller Maerki, S, Parapini, Silvia, Marini, S., Gemma, Sandra, Kukreja, G, Guiso, Giovanna, Caccia, Silvio, Fattorusso, C, Rottmann, Matthias, Brun, Reto, Campiani, Giuseppe, Yardley, Vanessa, Coccone, S. S., Campiani G., Fiorini I., Croft, Simon   +121 more
core   +2 more sources

Transmission Raman Spectroscopy (TRS) for Accurate Authentication of API in Coated Hydroxychloroquine (HCQ) Tablets

Journal of Raman Spectroscopy, EarlyView.
We report the development and use of a transmission Raman spectroscopy (TRS) system for a more accurate but nonintrusive way of authentication of API in coated HCQ tablets which otherwise is not possible using the backscattered (BS) configuration of Raman spectroscopy. The coating interference is found to be almost zero in case of the TRS and a greater
Vijay Kumar, Khan Mohammad Khan, Hemant Krishna, Khageswar Sahu, Srinibas Satapathy, Shovan Kumar Majumder   +5 more
wiley   +1 more source

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

JSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune, Amare Bitew Mekonnen, Getahun Yemata   +2 more
wiley   +1 more source

Pattern of the Antimalarials Prescription during Pregnancy in Bangui, Central African Republic [PDF]

, 2011
Introduction. The aim of this study was to identify the antimalarials prescribed during the pregnancy and to document their timing. Method. From June to September 2009, a survey was conducted on 565 women who gave birth in the Castors maternity in Bangui.
Jean Delmont, Alain Le Faou, Elise Klement, Nestor Madji, Alexandre Manirakiza, Georges Soula, Remi Laganier, Djibrine Djallé, Luc Salva Heredeïbona, Moyen Methode   +9 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source