Results 31 to 40 of about 7,527 (154)
Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.ABSTRACT This study evaluated the phytochemical composition, antimicrobial activity, and in vivo protective effects of the hydroethanolic extract from Commiphora leptophloeos stem bark (HECL) against 5‐fluorouracil (5‐FU)‐induced intestinal mucositis. Despite the extensive traditional use of C.
Stphannie Jamyla de Araújo Barbosa +17 more
wiley +1 more source
Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]
, 1986 The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R. +5 more
core +1 more source
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs [PDF]
, 2014 Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy.
Wang, Xin
core +1 more source
Oral considerations in pediatric patients with acute lymphoblastic leukemia [PDF]
, 2017 Introduction: Acute lymphocytic leukemia is one of the most common type of cancer in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.
Aroso, Ricardo
core
Procjena cito-/genotoksičnosti irinotekana u V79-stanicama primjenom komet-testa, mikronukleus-testa i testa kromosomskih aberacija [PDF]
, 2010 Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 μg mL-1), recommended monotherapy dose (9 μg mL-1), and recommended combined therapy ...
A. Mahabir +36 more
core +2 more sources
Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy
ChemistryEurope, Volume 4, Issue 3, March 2026.Gold(I)–thiopurine complexes bearing chromophores and phosphine or N‐heterocyclic carbene ligands were developed as multimodal chemo‐photodynamic agents. They show good stability, moderate lipophilicity, and tunable photoresponse. 6‐TG enhances dark cytotoxicity, 6‐MP improves phototoxicity, and PPh3/NBD provide the most efficient photoactivation ...
Laura Agulló +3 more
wiley +1 more source
Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature [PDF]
, 2019 Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs.
Marsch, Amanda F, Shakhbazova, Anastasia
core
Improving therapeutic ratio In head and neck cancer with adjuvant and cisplatin-based treatments [PDF]
, 2013 Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional ...
Marcu, L.
core +3 more sources
Journal of Applied Toxicology, Volume 46, Issue 3, Page 733-753, March 2026.ABSTRACT The widespread use of antineoplastic drugs in cancer treatment has led to significant concerns regarding the potential health risks posed to healthcare professionals involved in the preparation, administration, and handling of these chemical compounds, including genotoxicity.
Thiago Guedes Pinto +6 more
wiley +1 more source
A simple and robust method for connecting small-molecule drugs using gene-expression signatures [PDF]
, 2008 BackgroundInteraction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with ...
Shu-Dong Zhang +20 more
core +3 more sources