Results 31 to 40 of about 6,952 (109)

Diverse potential of chimeric antigen receptor‐engineered cell therapy: Beyond cancer

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
1. In theory, CAR‐engineering therapy can achieve therapeutic effects by targeting cells expressing specific antigens and thereby eliminating or regulating disease‐related cell subpopulations. 2. Although CAR‐engineering therapy is currently only approved for the treatment of cancer, it has also shown potential in non‐tumour diseases. 3.
Lvying Wu, Lingfeng Zhu, Jin Chen
wiley   +1 more source

Anticancer drugs in the aquatic environment: where should we act and is nanofiltration a solution to this problem? [PDF]

, 2022
Anticancer drugs have been detected in hospital effluents, sewage effluents and river water samples. Due to the increasing number of cancer patients, an increase in the consumption of anticancer drugs is expected and therefore the development of ...
Cristóvão, Maria Beatriz Sá Mesquita da Silva
core  

An Unusual Case of 11αB‐Crystallin (CRYAB) Mutation as a Cause of Dilated Cardiomyopathy With Restrictive Physiology: A Case Report and Focused Review of the Literature

Clinical Case Reports, Volume 13, Issue 3, March 2025.
Mutations in αB‐crystallin (CRYAB) have been related to several diseases. Nevertheless, this mutation is a rare cause that has recently been linked to the onset of dilated cardiomyopathy. We describe a case of CRYAB mutation‐induced dilated cardiomyopathy with restrictive physiology.
Porras Bueno Cristian Orlando, Cruz Buitrago Roberto Hernando, Mariño Correa Alejandro, Cáceres Méndez Edward Andres, Eugenio Meek, Ríos Dueñas Edgar Giovanni   +5 more
wiley   +1 more source

Antineoplastic drugs [PDF]

, 2019
Antineoplastični lijekovi ili citostatici su skupina lijekova koji se koriste u svrhu liječenja stanica raka. Otkriven je i opisan veliki broj antineoplastičnih lijekova koji se međusobno razlikuju, a s obzirom na njihov mehanizam djelovanja mogu se ...
Knežević, Monika
core   +3 more sources

Oral considerations in pediatric patients with acute lymphoblastic leukemia [PDF]

, 2017
Introduction: Acute lymphocytic leukemia is one of the most common type of cancer in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.
Aroso, Ricardo
core  

The SUMOylated RREB1 interacts with KDM1A to induce 5‐fluorouracil resistance via upregulating thymidylate synthase and activating DNA damage response pathway in colorectal cancer

MedComm, Volume 6, Issue 3, March 2025.
5‐Fluorouracil (5‐FU) treatment triggers the Ras‐responsive element binding protein 1 (RREB1) expression and the formation of RREB1 and lysine demethylase 1A (KDM1A) complex which binds to the promoter of thymidylate synthase (TS) and thymidine kinase (TK1), and be recruited to phosphorylated H2AX foci, contributing to reduced DNA damage and enhanced ...
Ya‐Nan Deng, Lan Huang, Shan Gao, Zenghua Sheng, Yinheng Luo, Nan Zhang, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Xianghui Fu, Shufang Liang   +10 more
wiley   +1 more source

Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]

, 2019
Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F., Kamel, Sarah, Neubauer, Peter, Wagner, Anke, Wetterwald, Albane   +4 more
core   +1 more source

Application of Nanomaterials in the Repair and Regeneration of Lymphatic Organs and Corresponding Biophysical Simulation Strategies

Advanced NanoBiomed Research, Volume 5, Issue 2, February 2025.
Immune system diseases, tumors, and injuries can damage lymphoid organs and impair immune function. Treatments like chemotherapy and radiotherapy exacerbate these issues, leading to dysfunction and increased infection risk. Nanotechnology plays a crucial role in regenerating lymphoid organs and restoring immune function through targeted drug delivery ...
Bangheng Liu, Dong‐An Wang
wiley   +1 more source

Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group

Journal of Pediatric Gastroenterology and Nutrition, Volume 80, Issue 2, Page 374-393, February 2025.
Abstract Objective We aimed to provide an evidence‐supported approach to diagnose, monitor, and treat children with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). Methods The core group formulated seven PICO‐structured clinical questions.
Patrick F. van Rheenen, Kaija‐Leena Kolho, Richard K. Russell, Marina Aloi, Annamaria Deganello, Séamus Hussey, Norman Junge, Jan De Laffolie, Mark R. Deneau, Emer Fitzpatrick, Anne M. Griffiths, Iva Hojsak, Emanuele Nicastro, Andreia Nita, Mikko Pakarinen, Amanda Ricciuto, Lissy de Ridder, Aurelio Sonzogni, Andrea Tenca, Marianne Samyn, Giuseppe Indolfi   +20 more
wiley   +1 more source

Multi-Institutional experience with FOLFIRINOX in pancreatic adenocarcinoma [PDF]

, 2012
Combination chemotherapy with FOLFIRINOX (oxaliplatin, irinotecan, fluorouracil, and leucovorin) was shown to be effective in a large phase III trial.
Gao, Feng, Linehan, David, Lockhart, A Craig, Lubner, Sam, McWilliams, Robert, Menias, Christine, Peddi, Parvin F, Picus, Joel, Sorscher, Steven M, Suresh, Rama, Tan, Benjamin R, Wang, Jian, Wang-Gilliam, Andrea   +12 more
core   +3 more sources