Results 261 to 270 of about 90,280 (287)
Some of the next articles are maybe not open access.
Are cationic antimicrobial peptides also ‘double-edged swords’?
Expert Review of Anti-infective Therapy, 2008The present view focuses on the possibility that cationic antimicrobial peptides (CAMPs) might, in addition to their killing effects due to permeabilization of microbial membranes, also function similarly to beta-lactam antibiotics to activate nascent autolytic wall enzymes, leading to bacteriolysis.
Isaac, Ginsburg, Erez, Koren
openaire +2 more sources
Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review
Current Protein & Peptide Science, 2019Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms.
Sara, Silva, Nuno, Vale
openaire +2 more sources
Novel Therapies Based on Cationic Antimicrobial Peptides
Current Pharmaceutical Biotechnology, 2006Cationic antimicrobial peptides serve as critical defense molecules protecting the host from invading bacteria, viruses and fungi. These antimicrobial peptides are widely distributed in nature and in vertebrates they have been localized to numerous tissues and cells.
openaire +2 more sources
Russian Journal of Bioorganic Chemistry, 2018
Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
openaire +1 more source
Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
openaire +1 more source
Nanomechanical response of bacterial cells to cationic antimicrobial peptides
Soft Matter, 2014The effectiveness of antimicrobial compounds can be easily screened, however their mechanism of action is much more difficult to determine. Many compounds act by compromising the mechanical integrity of the bacterial cell envelope, and our study introduces an AFM-based creep deformation technique to evaluate changes in the time-dependent mechanical ...
Shun, Lu +3 more
openaire +2 more sources
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
Nature Chemical Biology, 2013Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models.
Ashley L, Hilchie +2 more
openaire +2 more sources
Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents
Biomaterials, 2011Antimicrobial peptides (AMPs) secreted by the innate immune system are prevalent as the effective first-line of defense to overcome recurring microbial invasions. They have been widely accepted as the blueprints for the development of new antimicrobial agents for the treatment of drug resistant infections.
Nikken, Wiradharma +5 more
openaire +2 more sources
Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature
ChemMedChem, 2020AbstractAntimicrobial peptides are ubiquitous in multicellular organisms and have served as defense mechanisms for their successful evolution and throughout their life cycle. These peptides are short cationic amphiphilic polypeptides of fewer than 50 amino acids containing either a few disulfide‐linked cysteine residues with a characteristic β‐sheet ...
openaire +2 more sources
Short Linear Cationic Antimicrobial Peptides: Screening, Optimizing, and Prediction
2008The problem of pathogenic antibiotic-resistant bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa is worsening, demonstrating the urgent need for new therapeutics that are effective against multidrug-resistant bacteria. One potential class of substances is cationic antimicrobial peptides.
Kai, Hilpert +2 more
openaire +2 more sources
Cationic peptides: effectors in innate immunity and novel antimicrobials
The Lancet Infectious Diseases, 2001Cationic antimicrobial peptides are produced by all organisms, from plants and insects to human beings, as a major part of their immediately effective, non-specific defences against infections. With the increasing development of antibiotic resistance among key bacterial pathogens, there is an urgent need to discover novel classes of antibiotics ...
openaire +2 more sources