Results 141 to 150 of about 119,446 (259)

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Breaking the outer membrane barrier: structure, targets, and antimicrobial strategies for Gram-negative bacteria. [PDF]

Front Microbiol
Xu F, Xie Y, Yu W, Wang Z.
europepmc   +1 more source

A High‐Performance and Fully Recyclable Supramolecular Nanofibrous Membrane for Multifunctional Air Filtration

Advanced Science, EarlyView.
A green, thermoreversible self‐assembly strategy yields a multifunctional and recyclable supramolecular nanofibrous membrane. Graphene oxide (GO) nanosheet acts as a heterogeneous nucleation‐templating agent, simultaneously modulating the supramolecular crystal packing while tailoring the nanofibrous architecture for elite performance.
Wenjing Sun, Ding Yuan, Jiaqi Wan, Junyu Chen, Zhen Yan, Yinuo Yan, Senjie Dong   +6 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Topical Formulations Containing Mentha piperita for Wound Healing: A Scoping Review. [PDF]

Chem Biodivers
Araújo LG, Vila-Nova BG, Abreu AG.
europepmc   +1 more source

Targeted Thrombolysis via CCR2‐Engineered Macrophage‐Mimicking Microbubbles Safely Ablates Venous, Arterial, and Microvascular Thrombosis

Advanced Science, EarlyView.
CCR2‐Enhanced Macrophage Membrane–Camouflaged Microbubbles for MCP‐1–Mediated Thrombus Targeting and Ultrasound‐Triggered Urokinase Release. ABSTRACT The clinical management of thrombosis, a primary cause of death worldwide, is hampered by the limitations of current thrombolytic agents, including short half‐life and high risk of off‐target bleeding ...
Buying Li, Changjin Lu, Shijie Gao, Dandan Chen, Xue Heng, Kibret Mequanint, Malcolm Xing, Gaoxing Luo, Haisheng Li   +8 more
wiley   +1 more source

Antimicrobial Peptide Activity in Lipid Bilayers with Smooth-Type Lipopolysaccharides. [PDF]

Anal Chem
Hashimoto W, Takeuchi N, Hagiri Y, Sato M, Kawano R.   +4 more
europepmc   +1 more source

Defect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy

Advanced Science, EarlyView.
This study develops defect‐rich ultrathin ZnCuW‐LDH nanosheets (DR‐ZnCuW‐LDH) via acid etching. DR‐ZnCuW‐LDH exhibits fourfold enhanced US‐triggered ROS production due to oxygen defects and electronic modulation, demonstrating potent antibacterial efficacy in vitro/vivo.
Qian Liu, Yu Yang, Rui Zhao, Linwei Huang, Xingyu Qi, Min Wu, Jianliang Shen   +6 more
wiley   +1 more source